Foxd3 joins the small, but growing list of stem cell regulating genes
In the search to understand the nature of stem cells, researchers at the University of Pennsylvania School of Medicine have identified a regulatory gene that is crucial in maintaining a stem cells ability to self-renew. According to their findings, the Foxd3 gene is a required factor for pluripotency – the ability of stem cells to turn into different types of tissue – in the mammalian embryo. Their research is presented in the October 15th issue of the journal Genes and Development.
"Stem cells represent a unique tissue type with great potential for disease therapy, but if we are to use stem cells then we ought to know the basis of their abilities," said Patricia Labosky, PhD, an Assistant Professor in the Department of Cell and Developmental Biology. "Among the stem cell regulatory genes, it appears that Foxd3 gene expression keeps stem cells from quickly differentiating – that is, developing into different types of tissue – holding back the process so that an embryo will have enough stem cells to continue developing normally."
Greg Lester | EurekAlert!
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