Mechanism may provide insights into development and cancer
When cells divide in two, they must carefully manage the process by which their DNA is replicated and then apportioned to the daughter cells. In one critical step along the way, the replicated DNA strands - or sisters - are held together for a period by a temporary scaffold of bridging proteins. When the timing is right, the proteins unzip, allowing the DNA sisters to separate. Errors in this or other steps in cell division can lead to cell death, faulty development, or cancer, which is largely defined as misregulated cell division.
Scientists have had a number of questions about these important bridging proteins, called cohesins. For example, how and where do the proteins attach themselves to the DNA? To protect genes from inappropriate activation, DNA is tightly wrapped around small proteins called histones and then further coiled into a higher structure called chromatin that serves as an effective accessibility barrier to the genes.
Franklin Hoke | EurekAlert!
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