Professor David Craik and Dr Richard Clark from the Institute for Molecular Bioscience have received $218,275 from the National Health and Medical Research Council (NHMRC) to aid in translating their research into a product available for Australians to use.
Studies on the molecule they have developed have shown that it is effective in relieving neuropathic pain in animals.
“Neuropathic pain is one of the most severe forms of chronic pain, and very difficult to treat,” Dr Clark said.
“Regular pain occurs when the nervous system is stimulated by, for example, an injury, whereas neuropathic pain occurs when the nervous system itself is damaged.”
“Current treatments in neuropathic pain only provide meaningful relief for one in three patients, and all of the current market-leading drugs have serious side effects, as well as taking up to three weeks to begin to take effect.”
Peptides (small proteins) from cone snail venom have attracted recent attention from scientists, as they can target receptors with a high degree of accuracy, thus eliminating severe side effects.
But peptides also degrade rapidly in the body. Professor Craik and Dr Clark have overcome this problem by engineering a circular peptide, using a circular protein backbone discovered by Professor Craik and found in plants such as violets.
The NHMRC Development grant will allow the researchers to further test their molecule to fully establish its therapeutic potential.
“Successful outcomes from this project will provide additional confirmation of the suitability of our molecule as a treatment for neuropathic pain,” Dr Clark said.
“Armed with these data, we will be able to secure a commercial partner and develop this molecule into a tablet for sufferers of chronic pain.”
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy