Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alligator blood may put the bite on antibiotic-resistant infections

08.04.2008
Despite their reputation for deadly attacks on humans and pets, alligators are wiggling their way toward a new role as potential lifesavers in medicine, biochemists in Louisiana reported today at the 235th national meeting of the American Chemical Society.

They described how proteins in gator blood may provide a source of powerful new antibiotics to help fight infections associated with diabetic ulcers, severe burns, and “superbugs” that are resistant to conventional medication.

Their study, described as the first to explore the antimicrobial activity of alligator blood in detail, found a range of other promising uses for the gator’s antibiotic proteins. Among them: combating Candida albicans yeast infections, which are a serious problem in AIDS patients and transplant recipients, who have weakened immune systems, the scientists say.

“We’re very excited about the potential of these alligator blood proteins as both antibacterial and antifungal agents,” says study co-author Mark Merchant, Ph.D., a biochemist at McNeese State University in Lake Charles, La. “There’s a real possibility that you could be treated with an alligator blood product one day.”

... more about:
»Merchant »antibiotic »bacteria »blood »gator »infections

Previous studies by Merchant showed that alligators have an unusually strong immune system that is very different from that of humans. Unlike people, alligators can fight microorganisms such as fungi, viruses, and bacteria without having prior exposure to them. Scientists believe that this is an evolutionary adaptation to promote quick wound healing, as alligators are often injured during fierce territorial battles.

In collaboration with Kermit Murray and Lancia Darville, both of Louisiana State University in Baton Rouge, Merchant and colleagues collected blood samples from American alligators. They then isolated disease-fighting white blood cells (leucocytes) and extracted the active proteins from those cells.

In laboratory tests, tiny amounts of these protein extracts killed a wide range of bacteria, including MRSA (methicillin-resistant Staphylococcus aureus), the deadly bacteria that are moving out of health care settings and into the community. These “superbugs” are increasingly resistant to multiple antibiotics and cause thousands of deaths each year.

The proteins also killed six out of eight different strains of Candida albicans, the researchers say. Their previous research also suggests that blood proteins may help fight HIV, the virus that causes AIDS.

The scientists are working to identify the exact chemical structures of the antimicrobial proteins and determine which proteins are most effective at killing different microbes. The gator blood extract may contain at least four promising substances, they estimate.

With the chemical structures in hand, scientists can begin developing them into antibacterial or antifungal drugs, including pills and creams, for fighting infections. These drugs show particular promise as topical ointments, Merchant says. Gator-blood creams could conceivably be rubbed onto the foot ulcers of patients with diabetes to help prevent the type of uncontrolled infections that lead to amputations, he says. The creams could also be applied to the skin of burn patients to keep infections at bay until damaged skin can heal, the researcher adds.

Merchant suggests that the proteins might be called “alligacin.” If studies continue to show promise, the drugs could land on pharmacy shelves in another seven to ten years, he estimates. Until then, don’t try to create your own home-remedies using alligator blood, as raw, unprocessed blood could make you sick or even kill you if injected, the researcher cautions.

Similar antimicrobial substances might also be found in related animals such as crocodiles, Merchant notes. In the future, he plans to study blood samples from alligators and crocodile species throughout the world to test their disease-fighting potential. The state of Louisiana and the National Science Foundation provides funding for this research.

Charmayne Marsh | EurekAlert!
Further information:
http://www.acs.org

Further reports about: Merchant antibiotic bacteria blood gator infections

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>