Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New means of protection against sepsis

17.12.2007
Scientists from six Scientific-Research Institutes in Puschino, Moscow and St. Petersburg have jointly undertaken a research effort to investigate the HSP70 heat shock protein’s ability to prevent development of septic shock.

Sepsis remains the main death cause in clinics of intensive therapy despite many years of scientists’ continuous research. In the USA and European countries, sepsis develops annually with over 500,000 patients, on top of that the number of confirmed cases is growing by 1.5% every year. Sepsis occurs as a result of the activity of endotoxins, Lipopolysaccharides of bacteria.

Endotoxins stimulate immune system cells, and in the long run this causes hormonal and biochemical dysfunctions of the main bodily organs, in particular, the liver and kidneys. The body tries to protect itself with the help of different means including the heat shock protein. The heat shock protein protects cells and the overall organism against various diseases, including ischemia, inflammation, cancer, as well as metabolic or neurodegenerative diseases. Since that time there have been developed various methods of getting and clearing one of the heat shock proteins - HSP70 - which scientists are currently trying to accommodate for therapeutic purposes. Russian experts have investigated the effect of the HSP70 as the sepsis prevention factor on rats.

The scientists simulated sepsis having injected endotoxins intravenously - Lipopolysaccharide of the Colibacillus, or Salmonella. Ten minutes before or 10 minutes after the endotoxin injection, the rats would be injected the heat shock protein, derived from the bull muscles and thoroughly refined. The reference group rats were injected the physiological solution. The researchers took measurements of the blood biochemical parameters of the laboratory animals, such as glucose and the whole protein concentration, albumin, triglycerides, creatinine and bilirubin tests. The blood tests would be taken in some cases before the injection, in other cases - 20 minutes after and in some other cases - 5 hours after the injection. Before the experiment the scientists had confirmed that the heat shock protein itself did not impact the blood composition, therefore it was harmless.

... more about:
»Endotoxin »Injection »Sepsis »effect »heat

The experiment proved the following: if the heat shock protein is injected 10 minutes before the infection, it produces positive protective effect and stabilizes some of the blood indexes. If the protein is injected after the endotoxin injection, the effect is much weaker. In this case, the protein positively affects values of two blood indexes only: concentration of the whole protein and albumin, and only provided that the Escherichia coli endotoxin was used for the injection.

However, the researchers believe that the discovered heat shock protein’s antiseptic effect is an important factor in terms of possibility to reduce the animal death-rate caused by endotoxins of different origins. They assume that later on this protein can be used to produce a drug or as a preventive protection agent against sepsis in human beings treatment.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

Further reports about: Endotoxin Injection Sepsis effect heat

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>