Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New regulator discovered for information transfer in the brain

20.06.2013
The protein mSYD1 has a key function in transmitting information between neurons. This was recently discovered by the research group of Prof Peter Scheiffele at the Biozentrum, University of Basel. The findings of the investigations have been published in the scientific journal “Neuron”.

Synapses are the most important sites of information transfer between neurons. The functioning of our brain is based on the ability of the synapses to release neurotransmitter substances in a fraction of a second, so that neuronal signals can be rapidly propagated and integrated.


Neuron with synaptic contacts.
(Image: Biozentrum)

Peter Scheiffele’s team has now identified a new mechanism, which ensures that synaptic vesicles, the carrier of the transmitter substances, are concentrated at their designated place, thereby contributing to rapid signal transmission.

mSYD1 as organizer of synaptic structures
The speed and precision of synaptic transmission is based on a highly complex protein apparatus in the synapse. A concentration of synaptic vesicles is found at the synaptic contact sites between neurons. When a nerve cell is activated, vesicles fuse with the edge of the synapse, the so-called active zone, and send neurotransmitters to the neighboring cells.

Peter Scheiffele’s research group has now identified a previously unknown protein called mSYD1, which regulates the deposition of the vesicles at the active zone. In nerve cells, in which no mSYD1 protein is present, synaptic contacts continue to be formed but the accumulation of the synaptic vesicles at the active zone is disrupted. This results in a significant reduction of synaptic transmission.

Inactive mSYD1 in autistic disorders
These findings provide important new insights into the mechanisms underlying the formation of functional neuronal networks. In patients with a developmental disorder belonging the autism spectrum, mSYD1 is one of a group of genes that are inactivated. In further investigations, the research group is now looking at how the inactivation of mSYD1 affects the behavior of mice, in order to gain insights into the fundamental neuronal defects associated with autism.

Original Citation
Corinna Wentzel, Julia Sommer, Ramya Nair, Adeline Stiefvater, Jean-Baptiste Sibarita, and Peter Scheiffele (2013)
mSYD1A, a Mammalian Synapse-Defective-1 Protein, Regulates Synaptogenic Signaling and Vesicle Docking.
Neuron; Published online June 19, 2013.

Further Information
Prof. Dr. Peter Scheiffele, Biozentrum, University of Basel, phone: +41 61 267 21 94, Email: peter.scheiffele@unibas.ch

Christoph Dieffenbacher | Universität Basel
Further information:
http://www.unibas.ch

More articles from Life Sciences:

nachricht 'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology

nachricht Microfluidics probe 'cholesterol' of the oil industry
23.10.2017 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>