Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rapid response in cases of smoke poisoning

04.09.2012
Smoke poisoning can be caused by a number of things, including cyanides, the salts of hydrocyanic acid.
Because the quick diagnosis and treatment of victims with cyanide poisoning is critical and often lifesaving, it is very surprising that a cyanide test for emergency situations is not yet available. Now, chemists at the University of Zurich have developed a simple and reliable procedure to detect blood cyanide in less than two minutes.

The main cause of cyanide poisoning is smoke inhalation in closed spaces during fires. Cyanides, the salts of hydrocyanic acid, inhibit cellular respiration and may lead to coma or death. The rapid administration of a cyanide antidote is essential for successful treatment. Previously, detecting cyanide in the blood took up to an hour and could only be performed in the laboratory, a lengthy process that is poorly suited for emergency situations.
As a result, emergency doctors and paramedics are forced to administer antidotes based solely on presumptive diagnoses. Now, chemists at the University of Zurich have succeeded in detecting blood cyanide in less than two minutes and without any laboratory equipment: UZH chemists Christine Männel-Croisé and Felix Zelder combined a cyanide color test with an extraction method to produce results quickly and reliably.

The newly developed procedure works with only a tiny drop of blood mixed in a detection vial with a pH buffer, water, and a cobalt-based chemosensor. If the blood contains cyanide, the solid phase of the vial turns purple.

Two-step procedure to detect blood cyanide: 1) The chemosensor is added to the blood sample. If cyanide is present in the blood, it forms a purple complex with the chemosensor. The solution is squeezed through a syringe containing a solid phase. 2) The solid phase is rinsed with water to remove the blood, leaving the violet complex that the cyanide formed with the chemosensor.

Picture: UZH

Faster, easier, more versatile

“What I like most about our method is that detection is possible solely with the naked eye, and it needs only a drop of blood,” says Zelder. Quantitative measurements are also possible, thereby enabling emergency responders to determine the grade of cyanide poisoning. The correct dosage of antidote can be chosen, and detoxification can be monitored during treatment. “In principle, our method meets all the requirements for application in emergency situations,” explains Christine Männel-Croisé. Currently, Männel-Croisé and Zelder are in discussion with paramedics to test their method in cases of emergency.

Further reading:
Christine Männel-Croisé and Felix Zelder. Anal. Methods, 2012, 4, 2632.

Contact:
Dr. Felix Zelder
Institute of Inorganic Chemistry
University of Zurich
Phone: +41 44 635 46 24
Eemail: zelder@aci.uzh.ch

Nathalie Huber | Universität Zürich
Further information:
http://www.uzh.ch

More articles from Life Sciences:

nachricht Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology

nachricht Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>