Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein in the envelope enclosing the cell nucleus - a new piece of the puzzle in research on cancer and stem cells?

17.06.2009
A research team led by Professor Einar Hallberg at the Department of Life Sciences at Södertörn University in Sweden has discovered a new protein in the inner membrane of the cell nucleus. This protein may play an important role in cell division and now provides a new piece of the puzzle to study in cancer research

All living organisms are made up of cells. The cell consists of different "compartments" that have different functions. In one of the compartments, the cell nucleus, there is genetic information about how the organism's proteins should look like, and when they should be produced.

The cell nucleus is enclosed by a double lipid membrane that is called the nuclear envelope. All transports in and out of the nucleus take place through pores in the nuclear envelope. It is estimated that there are some 100 different proteins in the nuclear envelope, but today scientists do not yet know precisely how they function.

The protein that the Södertörn researchers have now discovered, called Samp1, normally exists in the membrane envelope that surrounds the cell nucleus. During cell division it turned out that it was part of the process that distributes the chromosomes evenly between the daughter cells, the so-called "mitotic spindle". The protein was therefore named Samp1 (Spindle associated membrane protein 1).

"This discovery was unexpected, since it was previously not believed that integral proteins that are embedded in membranes could be in the mitotic spindle. Nor was it previously understood what functions such proteins would have there," says Professor Hallberg.

The distribution of chromosomes during cell division is extremely rigidly regulated, and the slightest error can lead to the development of tumors. Samp1 will now be a key piece of the puzzle to study in cancer research.

"An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells", (Journal of Cell Science 122, 2100-2107), was part of a doctoral thesis at the Karolinska Institutet that was defended at Södertörn University by Dr. Charlotta Buch on February 20 this year.

Einar Hallberg's research team discovered in their study that the Samp1 protein has connections to the cell skeleton outside the cell nucleus. This takes place between cell divisions, when the protein is in the inner membrane of the cell nucleus. It is possible that Samp1 may play an important role when mechanical signals from the outside of the cell are transmitted to the genes in the cell nucleus. Professor Hallberg's research group is now focusing on investigating what role Samp1 might have in the transmission of mechanical signals from the outside of the cell to the genes.

Recently mechanical signaling has been shown to be extremely important in how the body's cells are organized to form various organs. For instance, cultured stem cells develop into nerve cells, muscle cells, or bone cells depending on the stiffness of the material they grow on. Increased knowledge about mechanical signaling is of great importance to stem cell research and future regenerative medicine.

Contact: Professor Einar Hallberg, e-mail:einar.hallberg@sh.se,
phone: +46 (0)8-608 47 33
Pressofficer Mari Gerdin: mari.gerdin@sh.se; +46-76 785 41 41

Mari Gerdin | idw
Further information:
http://www.vr.se
http://diss.kib.ki.se/2009/978-91-7409-334-6/

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>