Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein in the envelope enclosing the cell nucleus - a new piece of the puzzle in research on cancer and stem cells?

17.06.2009
A research team led by Professor Einar Hallberg at the Department of Life Sciences at Södertörn University in Sweden has discovered a new protein in the inner membrane of the cell nucleus. This protein may play an important role in cell division and now provides a new piece of the puzzle to study in cancer research

All living organisms are made up of cells. The cell consists of different "compartments" that have different functions. In one of the compartments, the cell nucleus, there is genetic information about how the organism's proteins should look like, and when they should be produced.

The cell nucleus is enclosed by a double lipid membrane that is called the nuclear envelope. All transports in and out of the nucleus take place through pores in the nuclear envelope. It is estimated that there are some 100 different proteins in the nuclear envelope, but today scientists do not yet know precisely how they function.

The protein that the Södertörn researchers have now discovered, called Samp1, normally exists in the membrane envelope that surrounds the cell nucleus. During cell division it turned out that it was part of the process that distributes the chromosomes evenly between the daughter cells, the so-called "mitotic spindle". The protein was therefore named Samp1 (Spindle associated membrane protein 1).

"This discovery was unexpected, since it was previously not believed that integral proteins that are embedded in membranes could be in the mitotic spindle. Nor was it previously understood what functions such proteins would have there," says Professor Hallberg.

The distribution of chromosomes during cell division is extremely rigidly regulated, and the slightest error can lead to the development of tumors. Samp1 will now be a key piece of the puzzle to study in cancer research.

"An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells", (Journal of Cell Science 122, 2100-2107), was part of a doctoral thesis at the Karolinska Institutet that was defended at Södertörn University by Dr. Charlotta Buch on February 20 this year.

Einar Hallberg's research team discovered in their study that the Samp1 protein has connections to the cell skeleton outside the cell nucleus. This takes place between cell divisions, when the protein is in the inner membrane of the cell nucleus. It is possible that Samp1 may play an important role when mechanical signals from the outside of the cell are transmitted to the genes in the cell nucleus. Professor Hallberg's research group is now focusing on investigating what role Samp1 might have in the transmission of mechanical signals from the outside of the cell to the genes.

Recently mechanical signaling has been shown to be extremely important in how the body's cells are organized to form various organs. For instance, cultured stem cells develop into nerve cells, muscle cells, or bone cells depending on the stiffness of the material they grow on. Increased knowledge about mechanical signaling is of great importance to stem cell research and future regenerative medicine.

Contact: Professor Einar Hallberg, e-mail:einar.hallberg@sh.se,
phone: +46 (0)8-608 47 33
Pressofficer Mari Gerdin: mari.gerdin@sh.se; +46-76 785 41 41

Mari Gerdin | idw
Further information:
http://www.vr.se
http://diss.kib.ki.se/2009/978-91-7409-334-6/

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>