Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein in the envelope enclosing the cell nucleus - a new piece of the puzzle in research on cancer and stem cells?

17.06.2009
A research team led by Professor Einar Hallberg at the Department of Life Sciences at Södertörn University in Sweden has discovered a new protein in the inner membrane of the cell nucleus. This protein may play an important role in cell division and now provides a new piece of the puzzle to study in cancer research

All living organisms are made up of cells. The cell consists of different "compartments" that have different functions. In one of the compartments, the cell nucleus, there is genetic information about how the organism's proteins should look like, and when they should be produced.

The cell nucleus is enclosed by a double lipid membrane that is called the nuclear envelope. All transports in and out of the nucleus take place through pores in the nuclear envelope. It is estimated that there are some 100 different proteins in the nuclear envelope, but today scientists do not yet know precisely how they function.

The protein that the Södertörn researchers have now discovered, called Samp1, normally exists in the membrane envelope that surrounds the cell nucleus. During cell division it turned out that it was part of the process that distributes the chromosomes evenly between the daughter cells, the so-called "mitotic spindle". The protein was therefore named Samp1 (Spindle associated membrane protein 1).

"This discovery was unexpected, since it was previously not believed that integral proteins that are embedded in membranes could be in the mitotic spindle. Nor was it previously understood what functions such proteins would have there," says Professor Hallberg.

The distribution of chromosomes during cell division is extremely rigidly regulated, and the slightest error can lead to the development of tumors. Samp1 will now be a key piece of the puzzle to study in cancer research.

"An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells", (Journal of Cell Science 122, 2100-2107), was part of a doctoral thesis at the Karolinska Institutet that was defended at Södertörn University by Dr. Charlotta Buch on February 20 this year.

Einar Hallberg's research team discovered in their study that the Samp1 protein has connections to the cell skeleton outside the cell nucleus. This takes place between cell divisions, when the protein is in the inner membrane of the cell nucleus. It is possible that Samp1 may play an important role when mechanical signals from the outside of the cell are transmitted to the genes in the cell nucleus. Professor Hallberg's research group is now focusing on investigating what role Samp1 might have in the transmission of mechanical signals from the outside of the cell to the genes.

Recently mechanical signaling has been shown to be extremely important in how the body's cells are organized to form various organs. For instance, cultured stem cells develop into nerve cells, muscle cells, or bone cells depending on the stiffness of the material they grow on. Increased knowledge about mechanical signaling is of great importance to stem cell research and future regenerative medicine.

Contact: Professor Einar Hallberg, e-mail:einar.hallberg@sh.se,
phone: +46 (0)8-608 47 33
Pressofficer Mari Gerdin: mari.gerdin@sh.se; +46-76 785 41 41

Mari Gerdin | idw
Further information:
http://www.vr.se
http://diss.kib.ki.se/2009/978-91-7409-334-6/

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>