Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Our Normal Genetics May Influence Cancer Growth, Too

11.11.2010
The genes we possess not only determine the color of our eyes and hair and how our bodies grow, they might also influence the changes that occur in tumors when we develop cancer.

A study by researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) suggests that our normal genetic background – the genetic variations that we inherit – contributes to the kinds of DNA changes that occur in tumor cells as cancer develops.

The researchers compared multiple independent tumors from people with a form of skin cancer called squamous cell carcinoma (SCC) for losses and gains of DNA in tumor cells. They found that the pattern of these changes is quite similar in tumors from the same person but quite different in tumors from different individuals.

The findings, published in a recent issue of PLoS Genetics, may offer a new way to identify individuals at greater risk for developing cancer, the researchers say.

... more about:
»Cancer »DNA »Genetics »OSUCCC »SCC »genetic variation »tumor cells

“Our data strongly support the idea that an individual’s normal genetic constitution can strongly influence the genetic changes that occur when a person develops cancer,” says study leader Amanda Toland, assistant professor of medicine and a specialist in the genetics of cancer susceptibility at the OSUCCC – James.

“They may also provide another strategy to identify genetic variations within healthy individuals that may increase their odds of developing cancer,” she adds.

Toland and her collaborators analyzed 222 SCC tumors from 135 organ transplant recipients, who as a group are 65 to 250 times more likely to develop SCC than people in the general population. The researchers examined three or more separate tumors from 25 of these individuals.

They compared the genetic profiles of tumors from the same individual with those from other individuals for DNA copy number changes.

They found that the changes in SCCs from the same patient were statistically similar but significantly different when compared with other patients. They also found that in some cases a particular kind of genetic change is preferentially selected in tumors from the same individual.

“Overall,” Toland says, “our findings provide strong evidence that an individual’s genetic background plays a key role in driving the changes that occur in tumors during cancer development.”

Funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the American Cancer Society supported this research.

Other researchers involved in this study were Amy M. Dworkin, Dawn C. Allain and O. Hans Iwenofu of Ohio State University; Katie Ridd, Ritu Roy and Boris C. Bastian of University of California San Francisco; and Dianne Bautista, Singapore Clinical Research Institute, Singapore.

The Ohio State University Comprehensive Cancer Center- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is one of only 40 Comprehensive Cancer Centers in the United States designated by the National Cancer Institute. Ranked by U.S. News & World Report among the top cancer hospitals in the nation, The James is the 180-bed adult patient-care component of the cancer program at The Ohio State University. The OSUCCC-James is one of only seven funded programs in the country approved by the NCI to conduct both Phase I and Phase II clinical trials.

Darrell E. Ward | EurekAlert!
Further information:
http://www.osumc.edu

Further reports about: Cancer DNA Genetics OSUCCC SCC genetic variation tumor cells

More articles from Life Sciences:

nachricht New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute

nachricht X-ray experiments reveal two different types of water
27.06.2017 | Deutsches Elektronen-Synchrotron DESY

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Collapse of the European ice sheet caused chaos

27.06.2017 | Earth Sciences

NASA sees quick development of Hurricane Dora

27.06.2017 | Earth Sciences

New method to rapidly map the 'social networks' of proteins

27.06.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>