Critical missing links in a signaling-transcription cascade responsible for pivotal cell-fate decisions have been described for the first time in a paper in Cell. Identified through a combination of simulations and experiments, the links are part of circuit-like molecular control mechanisms for converting analog signals into binary responses central to the development of all cells.
The question of how identical cells develop into distinct cell types using the same signaling pathways is integral to our understanding of the cell life cycle. The mechanisms that determine cell fate decisions, leading cells with the same genes to distinct developmental outcomes, remain however poorly understood.
To study cell fate decisions, a research team headed by scientists at the RIKEN Research Center for Allergy and Immunology (RCAI) and the University College Dublin administered growth factors to MCF-7 breast cancer cells and analyzed responses in the extracellular regulated kinase 1/2 (ERK) cascade. Whereas one growth factor (epidermal growth factor or EGF) induces transient ERK activity leading to cell proliferation, the other (heregulin or HRG) induces ERK activity that is sustained, triggering cell differentiation. Connecting these analog ERK signaling patterns to their cell fates (proliferation/differentiation) is the phosphorylated transcription factor c-Fos, whose digital all-or-none expression acts as the output of the signaling system.
Comparing observational data with results of mathematical simulations, the researchers arrived at a “molecular circuit” model for c-Fos mediated cell differentiation composed of negative feedback loops, feed-forward loops and logical AND gates that reduce noise and generate stable output signals. The discovery of these simple circuit components, which are believed to govern differentiation across a variety of different cell types, provides fundamental insights into the underlying logic of cell-fate decision processes, opening the door to applications in areas such as regenerative medicine.
For more information, please contact:Dr. Mariko Okada-Hatakeyama
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A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
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A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
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For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
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Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
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23.02.2018 | Physics and Astronomy