Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The Link between Blood Flow and Dementia

02.08.2011
Dr. Gabor Petzold begins work as Research Group Leader at the DZNE and Senior Physician at the University Hospital of Bonn

High blood pressure is a typical risk factor for dementia. Why is that? What is the relationship between blood flow and dementia? These are the questions that Dr. Gabor Petzold is investigating at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. He is also Senior Physician at the Clinic for Neurology, where he is responsible for the outpatient clinic for vascular diseases.

Each brain activity consumes oxygen, which is carried by the blood to the brain. The blood flow is carefully regulated: When activity increases in a brain region there is a corresponding increase in blood flow in the same region. Impaired regulation of blood flow may lead to vascular dementia – a disease mainly characterized by slowing of mental activity. A relationship between cerebral blood flow and disease can be observed in other dementias as well. Petzold will examine these correlations in vascular dementia, in CADASIL (a congenital vascular disease), in symptoms of dementia following stroke, and in Alzheimer’s disease.

Petzold’s work has already provided some new insights into the cellular and molecular bases of the neural regulation of blood flow. For instance, he has shown the importance of astrocytes in the regulation mechanism. Astrocytes are cells that enclose blood vessels and are in contact with synapses, whose signals they transmit to the blood vessels. In Alzheimer’s patients, the signaling pathway regulating blood flow may be impaired. Although the cause of Alzheimer’s disease is considered to be abnormal protein deposition in the brain, impaired blood flow is assumed to accelerate the progress of the disease. Investigations have revealed that impaired cerebral blood flow occurs early on, before the symptoms of the disease appear. Timely intervention could hence delay the progress of the disease.

The exact molecular causes of vascular dementia or symptoms of dementia following a stroke are still unknown. Using highly sophisticated imaging technologies, which allow the observation of cells in vivo, Petzold and his research team plan to examine these diseases more closely with adequate models, thus hoping to obtain clues to potential new treatments. Another aim of the group is to develop new clinical therapies and diagnostics based on their research findings.

Petzold completed his specialization in neurology at the Charité University Hospital in Berlin. From 2005 to 2008 he conducted research at Harvard University; afterward he returned to the Charité, where he worked mainly as a physician. In Bonn, Petzold will divide his time between the lab and the clinic, and in this double capacity build a bridge between research and patient care.

Contact information:
Dr. Gabor Petzold
German Center for Neurodegenerative Diseases (DZNE)
Biomedizinisches Zentrum (BMZ), UKB
Sigmund-Freud-Str. 25
53127 Bonn
Phone: +49 (0) 228 287 51606
Email: gabor.petzold@dzne.de
Dr. Katrin Weigmann
German Center for Neurodegenerative Diseases (DZNE)
Press- und Public Relations
Holbeinstraße 13-15
53175 Bonn
Phone: +49 (0) 228 43302 263
Mobile: +49 (0) 173 - 5471350
Email: katrin.weigmann@dzne.de

Katrin Weigmann | idw
Further information:
http://www.dzne.de/

More articles from Life Sciences:

nachricht Stiffness matters
22.02.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht Separate brain systems cooperate during learning, study finds
22.02.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>