The optical trap is the latest innovation from researchers at the Jack Baskin School of Engineering at the University of California, Santa Cruz, who are developing new sensor technology for biomedical analysis and other applications.
"Ultimately, it could have applications for rapid detection of bacteria and viruses in hospitals, for cell sorting in research labs, and for process monitoring in chemical engineering," said Holger Schmidt, professor of electrical engineering and director of the W. M. Keck Center for Nanoscale Optofluidics at UCSC.
The new technique offers the potential to create a smaller, cheaper version of the sophisticated equipment used to perform fluorescence-activated cell sorting (FACS), Schmidt said.
"The capabilities of our optofluidic platform are continuing to grow. We have gone from the detection of single molecules and single viruses to now being able to control the movement of particles," he said.
Schmidt's group has received a $400,000 grant from the National Institutes of Health to explore particle trapping and sorting and other applications of the optofluidics platform. An article describing the optical trap for on-chip particle analysis has been published online by the journal Lab on a Chip. First author Sergei Kuhn was a postdoctoral researcher in Schmidt's lab and is now at the Max-Born Institute in Berlin. Coauthors include David Deamer and Philip Measor at UCSC and E. J. Lunt, B. S. Phillips, and A. R. Hawkins of Brigham Young University, where the optofluidic chips are fabricated.
Optical traps and "optical tweezers" use the momentum carried by the photons in a beam of light to exert forces on microscopic objects, enabling researchers to manipulate objects ranging from biological molecules to living cells. Schmidt's group developed a new way to perform optical trapping on a chip-based platform.
The technique relies on an earlier innovation from Schmidt's lab: a hollow-core optical waveguide that can direct a beam of light through a liquid-filled channel on a chip. To trap particles, the researchers used two laser beams at opposite ends of a channel. A particle gets trapped at the point where the forces exerted by the two beams are equal, and the particle can be moved by changing the relative power of the two laser beams.
"We can also use this like an optical leaf blower to push all the particles in a sample to the same spot and increase the concentration," Schmidt said. "The goal is to control the position and movement of particles through channels on a chip so they can be studied using fluorescence analysis and other optical methods."
The Jack Baskin School of Engineering at UCSC prepares technologists--and sponsors technology--for our changing world. Founded in 1997, Baskin Engineering trains students in six future-focused areas of engineering: biotechnology/information technology/ nanotechnology; information and communication infrastructure; mathematical and statistical modeling; software and services engineering; system design; and bioengineering. Baskin Engineering faculty conduct industry-leading research that is improving the way the world does business, treats the environment, and nurtures humanity.
Tim Stephens | EurekAlert!
A room with a view - or how cultural differences matter in room size perception
25.04.2017 | Max-Planck-Institut für biologische Kybernetik
Studying a catalyst for blood cancers
25.04.2017 | University of Miami Miller School of Medicine
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Earth Sciences
25.04.2017 | Life Sciences
25.04.2017 | Earth Sciences