Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


How genes link a mother's diet to the risk of obesity in her offspring


New research in The FASEB Journal suggests that epigenetic methylation blocks expression of the Pomc gene, leadings to delayed satiety response and increased food intake

Many research studies have made it clear that a mother's eating habits prior to pregnancy, during pregnancy and during lactation have a profound impact on her offspring and their propensity for developing weight problems, including obesity.

However, until now, the mechanisms behind this phenomenon were unclear. According to new research published in the September 2014 issue of The FASEB JournalF, scientists using an animal model found an epigenetic link between a mother's diet and an offspring's risk of future obesity.

This link hinges on the blocked expression of a gene called Pomc, which manages a discrete area of the brain that controls feeding behavior. Excess methylation on the DNA sequence blocks the ability to express this gene, leading to a late satiety response, increased food intake and eventually to obesity.

"Parental obesity and diet can affect the children's likelihood to overeat and develop obesity. Changes in epigenetic programming have been implicated as one of the mechanisms underlying this phenomenon," said Asaf Marco, Ph.D., a researcher involved in the work from the Faculty of Life Sciences at Bar Ilan University in Ramat-Gan, Israel. "We observed a clear correspondence between a specific epigenetic mechanism and weight gain, potentially allowing for early detection and prevention of obesity."

To make this discovery, Marco and colleagues fed female rats either a high-fat diet or a standard diet from post-weaning to adulthood and in separate groups, throughout pregnancy and lactation. All offspring, including those of the high-fat treated rats, received standard food after weaning until adulthood. Blood was analyzed for hormone levels and brain sections for epigenetic modification on the specific DNA sequence of interest.

Results showed that unmated female rats, chronically fed a high-fat diet, presented obesity associated with disruptions in an epigenetic mechanism that controls the production of Pomc. However, due to the sharp weight loss during lactation, rats who consumed a high-fat diet presented normal weight and a normalized epigenetic mechanism.

Because methylation on the genes is typically considered stable and relatively permanent, this opens the door for future drug development. Researchers found that epigenetic malprogramming induced by maternal high-fat diet had a long-term effect on the offspring's vulnerability to develop obesity. These effects were not reprogrammed by providing standard food to the pups after weaning and the offspring maintained their obesogenic phenotype until adulthood.

"Shining light on heritable, epigenetic factors that cause obesity should help us shed unwanted pounds in future generations," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This research shows that being overweight and obese has a direct impact on the genes we use to signal when it's time to stop eating."


Receive monthly highlights from The FASEB Journal by e-mail. Sign up at The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Asaf Marco, Tatiana Kisliouk, Tzlil Tabachnik, Noam Meiri, and Aron Weller. Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not "reprogrammed" by regular chow diet in rats. FASEB J. September 2014 28:4148-4157; doi:10.1096/fj.14-255620 ;

Cody Mooneyhan | Eurek Alert!

Further reports about: Biology FASEB epigenetic genes high-fat mechanism methylation offspring pregnancy weight

More articles from Life Sciences:

nachricht Flipping molecular attachments amps up activity of CO2 catalyst
06.10.2015 | DOE/Brookhaven National Laboratory

nachricht Safe nanomotors propelled by sugar
06.10.2015 | Max-Planck-Institut für Intelligente Systeme

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists shrink particle accelerator

Prototype demonstrates feasibility of building terahertz accelerators

An interdisciplinary team of researchers has built the first prototype of a miniature particle accelerator that uses terahertz radiation instead of radio...

Im Focus: Simple detection of magnetic skyrmions

New physical effect: researchers discover a change of electrical resistance in magnetic whirls

At present, tiny magnetic whirls – so called skyrmions – are discussed as promising candidates for bits in future robust and compact data storage devices. At...

Im Focus: High-speed march through a layer of graphene

In cooperation with the Center for Nano-Optics of Georgia State University in Atlanta (USA), scientists of the Laboratory for Attosecond Physics of the Max Planck Institute of Quantum Optics and the Ludwig-Maximilians-Universität have made simulations of the processes that happen when a layer of carbon atoms is irradiated with strong laser light.

Electrons hit by strong laser pulses change their location on ultrashort timescales, i.e. within a couple of attoseconds (1 as = 10 to the minus 18 sec). In...

Im Focus: Battery Production: Laser Light instead of Oven-Drying and Vacuum Technology

At the exhibition BATTERY + STORAGE as part of WORLD OF ENERGY SOLUTIONS 2015 in Stuttgart, the Fraunhofer Institutes for Laser Technology ILT and for Ceramic Technologies and Systems IKTS will be showing how laser technology can be used to manufacture batteries both cost- and energy-efficiently.

In the truest sense, it’s all about watts at the Dresden-based Fraunhofer Institute for Ceramic Technologies and Systems IKTS and the Aachen-based Fraunhofer...

Im Focus: New Sinumerik features improve productivity and precision

EMO 2015, Hall 3, Booth E06/F03

  • Drive optimization called automatically by the part program boosts productivity
  • Automatically switching the dynamic values to rapid traverse and interpolation...
All Focus news of the innovation-report >>>



Event News

EHFG 2015: Securing healthcare and sustainably strengthening healthcare systems

01.10.2015 | Event News

Conference in Brussels: Tracking and Tracing the Smallest Marine Life Forms

30.09.2015 | Event News

World Alzheimer`s Day – Professor Willnow: Clearer Insights into the Development of the Disease

17.09.2015 | Event News

Latest News

Graphene teams up with two-dimensional crystals for faster data communications

06.10.2015 | Information Technology

Laser-wielding physicists seize control of atoms' behavior

06.10.2015 | Physics and Astronomy

Flipping molecular attachments amps up activity of CO2 catalyst

06.10.2015 | Life Sciences

More VideoLinks >>>