Mobile DNA element allows conclusions on the evolution of apes
An international team of researchers that includes Christian Roos, Markus Brameier and Lutz Walter from the German Primate Center (DPZ) in Göttingen, have decoded the genome of gibbons from Southeast Asia. With this, the entire genetic information of five different species of this primate family has been sequenced for the first time.
Northern White-cheeked Gibbon male (Nomascus leucogenys)
Image: Tilo Nadler
Northern White-cheeked Gibbon female (Nomascus leucogenys)
Image: Tilo Nadler
Comparisons with the genome data of humans and our closest relatives, the great apes, show that while we all genetically have the same ancestors, the genetic information of the gibbons has changed more rapidly and stronger in the course of the evolutionary process.
The researchers could identify a new DNA element that only occurs in gibbons. This DNA element increases the mutation rate, and is thus of crucial importance for the evolutionary development. Thanks to the DNA element, the gibbon is also known as the one with the long, strong arms who elegantly moves through the forests of Southeast Asia. The study published in the current issue of Nature, allows important insights in the molecular fundamentals of the evolutionary process (Carbone et al. 2014)
The gibbons, known as small apes are genetically farther from humans than the great apes chimpanzees, bonobos, gorillas and orang-utans. In the genealogy of the evolutionary developments of primates, the gibbons do occupy a key position. In the course of the evolutionary process, they were the first to split from the hereditary line of the great apes and humans.
„The complete sequencing of the gibbon genome was pending until now“, says Christian Roos, a scientist from the Primate Genetics Laboratory at the DPZ. “In order to fully understand the human evolution and to draw conclusions on our evolutionary roots, we need to conduct phylogenetic research of our more distant relatives.“
Genetic disorder and jumping gene sections
In their genome analysis, the researchers discovered that the genetic information of the gibbons differs in their entirety from that of humans and of apes. “The genetic information itself is similar to ours”, explains Christian Roos. “However, large segments of DNA and in such, many genes are arranged differently on the individual chromosomes.” This "chromosomal disorder" is a key feature of the gibbon genome and has probably occurred after their secession from the ancestral line of the apes and humans.
Through further research on the gibbon DNA, scientists were finally able to identify a possible cause for these changes in the genome: A jumping DNA element called LAVA transposon can be copied and integrated elsewhere in the genome. So far, transposons or jumping genes have been detected in many different organisms. However, the LAVA transposon is unique to the gibbon genome.
The special feature of this DNA element is its positioning in precisely those genes that play a role in the chromosome distribution during cell division and thus influences them. Analyses of the phylogenetic development of the gibbon line also indicate a connection to the existence of the LAVA transposons. Their first appearance can be traced back with a high probability to the time of the splitting of the gibbons from the line of apes and humans.
Genetic basis for gibbon-specific way of life
Through comparative DNA analyses, the researchers could also identify genes subjected to a positive selection. In the course of evolution, genes that favored the adaptation of the gibbons to their way of life, continued to develop. These include genes responsible for anatomical specifications such as longer arms or stronger muscles. Gibbon genes, which have undergone a positive selection are, for example TBX5, which is required for the development of the front extremities and COL1A1, responsible for the development of the protein collagen. The latter is one of the main components of connective tissues in bones, teeth and tendons.
"These genes are positively selected only in the gibbon genome", says Christian Roos. “In future projects, sequencing will be performed on other gibbon species. We hope to be able to further characterize these genes and to identify other gibbon-specific genes.”
Carbone, L. et al. (2014): Gibbon genome and the fast karyotype evolution of small apes. Nature Epub ahead of print. DOI: 10.1038/nature13679
PD Dr. Christian Roos
Primate Genetics Laboratory
German Primate Center
phone +49 551 3851-300
Dr. Susanne Diederich
German Primate Center
phone: +49 551 3851-359
The German Primate Center (DPZ) – Leibniz Institute for Primate Research conducts biological and biomedical research with primates in infection research, neuroscience and primate biology. The DPZ maintains three field stations in the tropics and is the reference and service center for all aspects of primate research. The DPZ is one of 89 research and infrastructure facilities of the Leibniz Association.
http://medien.dpz.eu/webgate/keyword.html?currentContainerId=2301 - Printable images
http://www.dpz.eu/en/info-center/media-center/video.html - video (German language)
http://www.dpz.eu/en/news/news.html - DPZ website
Dr. Susanne Diederich | idw - Informationsdienst Wissenschaft
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology