Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Elasticity found to stretch stem cell growth to higher levels

04.10.2010
Findings published in Nature Biotechnology could revolutionize stem cell transplants

One of the major challenges in stem cell transplants is how to obtain sufficient numbers of these remarkably rare cells to put into patients. To help overcome this issue, research from the Centenary Institute, Royal Prince Alfred Hospital and the University of Sydney has found a way to increase the number of blood-forming stem cells when growing them outside of the body.

By using a unique stretchy surface that allows the cells to pull on it, the researchers found they could generate up to three times more stem cells than using current methods alone. Published today in the leading biotechnology journal Nature Biotechnology, lead author Professor John Rasko from the Centenary Institute and RPA Hospital announced these findings could significantly improve the outcomes of stem cell transplants.

Centenary Institute Head of Gene and Stem Cell Therapy Professor John Rasko* said: "Haemopoietic stem cells (HSCs) or blood-forming stem cells play a critical role in creating the blood cells in our body. In order to expand the number of these cells, researchers have attempted to reproduce the unique environment where stem cells live inside the body. In the past we have learnt how to use hormones and drugs to influence these niche environments but less is known about the effect of physical forces.

"Our research has, for the first time, successfully demonstrated that physical forces created by elasticity play a key role in blood-forming cell growth and may mimic the environment of stem cells inside our body. What we've discovered is that blood-forming stem cells like it to be super stretchy because, like a cat on a sofa, they like to pull on their environment."

Dr Jeff Holst#, first author of the publication, combined routinely-used cell hormones with a new elastic-like substance called tropoelastin to coat the plates on which the cells were grown. The study found that growing the stem cells on tropoelastin alone could create as many stem cells as the current hormone-based methods. But the combination of the two produced a super effect with the researchers finding they could create two or three times the number of stem cells than using standard methods on their own.

Professor Tony Weiss^ is a co-author of the Nature Biotechnology paper, and Professor of Biochemistry and Molecular Biotechnology at the University of Sydney. Professor Weiss said: "This is a superb, world class demonstration of leading Australian science. Our inventions are now giving us precise replicas of extraordinarily versatile, natural elastic proteins. By combining our research skills, we have developed a truly impressive technology that we hope will eventually be used to improve the way bone marrow is managed for better medical outcomes."

These findings could be good news for people who receive life-saving stem cell transplants (bone marrow and cord blood transplants) to treat diseased, damaged or faulty stem cells caused by various conditions or treatments such as leukaemia or chemotherapy.

Professor Rasko explained: "By increasing the number of stem cells we can grow outside of the body we could effectively use less bone marrow or cord blood to get the same result or use the same amount to get a much better result. For example, the small quantity of blood used from a cord blood donation often makes it suitable for small children only. Two cord blood donations are usually required to achieve safe transplants in older children or adults. However, in the future, we could use the blood from just one umbilical cord and then increase the number of stem cells to a viable level outside of the body before transplanting these life-saving cells into patients."

For more information on this research or the Centenary Institute visit www.centenary.org.au

*Professor John Rasko is Head of Gene and Stem Cell Therapy at the Centenary Institute. Professor Rasko is also Head, Cell and Molecular Therapies, Royal Prince Alfred Hospital and Professor, Sydney Medical School, University of Sydney.

#Dr Jeff Holst is Head of the Origins of Cancer Laboratory at the Centenary Institute, and is a research fellow at the University of Sydney.

^Professor Tony Weiss is Professor of Biochemistry and Molecular Biotechnology at the University of Sydney. Professor Weiss is also Head of Proteomics and Biotechnology, Molecular Bioscience, University of Sydney.

For the full paper or interviews, please contact Tanya Sarina, Communications Manager, Centenary Institute on:
p: +61 2 9565 6228
m: +61 2 431 029 215
e: t.sarina@centenary.org.au
About the Centenary Institute: The Centenary Institute is an independent medical research institute, affiliated with Royal Prince Alfred Hospital and the University of Sydney. Our unique blend of highly skilled staff and state-of-the art equipment and facilities has allowed us to become world leaders in three critical areas of medical research – cancer, cardiovascular disease and infectious diseases.

Tanya Sarina | EurekAlert!
Further information:
http://www.centenary.org.au

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>