Researchers at the Dana-Farber Cancer Institute in Boston have identified a new type of cell in mice that dampens the immune system and protects the animal's own cells from immune system attack.
This "suppressor" cell reduces the production of harmful antibodies that can drive lupus and other autoimmune diseases in which the immune system mistakenly turns on otherwise healthy organs and tissues.
The discovery, published in the September 16 issue of Nature (H Kim, et al.; Vol 467 in Letters), resulted from Lupus Research Institute funding to Harvey Cantor, MD, and colleagues on a separate immune system topic.
Now the discovery will be used to explore therapies that might control the hyperactive immune system in lupus. "These CD8+ T suppressor cells represent a potential new lever for lowering the strength of the immune response in autoimmune diseases such as lupus," Dr. Cantor said.
Staying Open to Discovery
Until now, scientists searching for cells involved in quieting the immune system response had focused their hunt on "regulatory CD4+ T cells"—also known as CD4+ Treg. Some of these cells have been shown to prevent harmful inflammatory diseases and infections.
In the Nature study, Harvey Cantor, MD, and his team reported that not just CD4+T cells but CD8+ T cells as well include a subset that helps dampen the immune response. Instead of reducing inflammation like their CD4 cousins, the CD8+ T regulatory cells ensure that the immune system doesn't produce antibodies that attack normal cells.
Lead author Hye-Jung Kim and colleagues made the discovery as they were winding up unrelated LRI-funded work into the role in autoimmunity of a protein found inside immune cells called osteopontin.
"Our LRI funds allowed us to carry out the early experiments that led to the definition of the CD8 suppressor cells." - Dr. Cantor.
"We were testing osteopontin's activity against a population of cells known as follicular T helper cells," explained Dr. Cantor. "We noted that the cells were responsive to osteopontin but also that they expressed what we knew to be the target of suppressor CD8+ T cells."
As next steps, Dr. Cantor and his team will investigate whether defective CD8+ T suppressor cells actually could be a cause of lupus and might serve as a powerful drug target for quieting the immune system response in autoimmunity.
Systemic lupus erythematosis is a chronic complex and potentially fatal autoimmune disease that affects more than 1.5-million Americans, mostly young women in their child-bearing years. Lupus causes the immune system to become hyperactive, forming antibodies that attack and damage the body's own tissues and vital organs including the heart, brain, kidneys and lungs. Lupus is a leading cause of cardiovascular disease, kidney disease and stroke among young women. As yet, there is no known cause or cure but the progress of recent discoveries is highly promising.
About The Lupus Research Institute
The Lupus Research Institute, (LRI) is the world's leading private supporter of innovative research in lupus, pioneering discovery to prevent, treat, and cure this complex and dangerous autoimmune disease. Founded in 2000 by families and shaped by scientists, the LRI champions scientific creativity and risk taking, mandating sound science and rigorous peer review to uncover and support only the highest ranked novel research. At the end of 2009, the Institute marked a breakthrough first decade – generating $100-million for bold and imaginative novel science in lupus – work that would not exist without the LRI's high risk, high reward strategy.
Liane Stegmaier | EurekAlert!
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Earth Sciences
11.12.2017 | Information Technology