Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

When chemists invent new rattles

13.02.2014
Chemists supported by the Swiss National Science Foundation (SNSF) have developed a one-pot synthesis process to encapsulate nanoparticles. This type of particle could improve the antimicrobial coating of implants.

Western populations live longer while enjoying good health. More and more people, for example young pensioners, have implants fitted to pursue their activities. But such surgery is not without its risks: during an operation, bacteria can reach the surface of the implant.

Once they have colonised the surface and formed a biofilm, the implant has to be removed and the wound cleaned. No new implant can be fitted till the infection has cleared up completely. These complications affect 2% of artificial hip joints, 5-10% of artificial knee joints and reach 50% for cardiac shunt and stent operations.

One way of fighting the growth of bacteria on the surface of the implant is the addition of an antimicrobial coating. A research group, led by Katharina Fromm of the University of Fribourg, has developed such a coating. It is currently undergoing in-vivo tests in a project funded by the CTI. This coating continually emits an antimicrobial agent - silver ions - for the duration of approximately three months.

Coating with longer effect

To prolong the efficiency of the coating, the researchers are currently working on a second-generation coating in which the silver nanoparticle would be encapsulated in silica. This would enhance the stability of the nanoparticle by isolating it from its environment. It would also slow down the diffusion of the silver and prolong the efficiency of the coat-ing. Another advantage of this method is that cells can tolerate a much greater number of silver nanoparticles if they are encapsulated than if they are naked.

To this end, the researchers have developed, within the context of the National Research Programme “Smart Materials” (NRP 62), a one-pot synthesis process (*) to encapsulate the nanoparticles. This allows them to determine the porosity and the size of the silica container in relation to the nanoparticle it contains. Under the microscope, it looks like a nanoscopic rattle.

Targeted release

To improve the performance of the coating even further, the researchers - in collaboration with Prof Christian Bochet’s group - are also working on bacterial sensors which they aim to attach to the encapsulated nanoparticles. If such a sensor were in place, the silver would only be released if a pathogen were nearby. This targeted release would further prolong the efficiency of the protection and it would prevent silver from being needlessly released into the organism.

The synthesis developed by the researchers allows for the development of various types of containers for various nanoparticles. The application potential for these nano-rattles is therefore considerable: by con-trolling the porosity of the container, it is for example possible to con-trol which molecules can get close to the nanoparticles. This, in turn, would make it possible to create a nanoreactor in which a chemical reaction can take place. The technique might also enable new battery designs in which each encapsulated nanoparticle would play the role of an electrode.

National Research Programme “Smart Materials” (NRP 62)

NRP 62 is a cooperation programme between the Swiss National Sci-ence Foundation (SNSF) and the Innovation Promotion Agency (CTI). The programme's aim is not only to promote scientific excellence but also to promote the successful industrial exploitation of smart materi-als and their application. NRP 62 also strives to link up the available skills and resources of various research institutions in Switzerland. The research work provides the technologies required to develop smart materials and the structures needed to integrate these. Having started its second phase at the beginning of 2013, NRP 62 now consists of 12 projects whose funding has been continued thanks to their high potential for practical application. NRP 62 will come to an end in 2015.

www.nrp62.ch

(*) Magdalena Priebe et Katharina M. Fromm (2014). One-pot synthesis and catalytic properties of encapsulated nanoparticles in silica nanocontainers. Particle & Particle Systems Characterization online: doi:10.1002/ppsc.

(Journalists can order the article as a PDF from the SNSF: com@snf.ch)

Contact
Prof. Katharina M. Fromm
Chemistry department
University of Fribourg
Chemin du Musée 9
1700 Fribourg
Tel. : ++41 26 300 87 32
E-mail : katharina.fromm@unifr.ch

Media - Abteilung Kommunikation | idw
Further information:
http://www.nfp62.ch
http://www.snsf.ch

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>