Western populations live longer while enjoying good health. More and more people, for example young pensioners, have implants fitted to pursue their activities. But such surgery is not without its risks: during an operation, bacteria can reach the surface of the implant.
Once they have colonised the surface and formed a biofilm, the implant has to be removed and the wound cleaned. No new implant can be fitted till the infection has cleared up completely. These complications affect 2% of artificial hip joints, 5-10% of artificial knee joints and reach 50% for cardiac shunt and stent operations.
One way of fighting the growth of bacteria on the surface of the implant is the addition of an antimicrobial coating. A research group, led by Katharina Fromm of the University of Fribourg, has developed such a coating. It is currently undergoing in-vivo tests in a project funded by the CTI. This coating continually emits an antimicrobial agent - silver ions - for the duration of approximately three months.
Coating with longer effect
To prolong the efficiency of the coating, the researchers are currently working on a second-generation coating in which the silver nanoparticle would be encapsulated in silica. This would enhance the stability of the nanoparticle by isolating it from its environment. It would also slow down the diffusion of the silver and prolong the efficiency of the coat-ing. Another advantage of this method is that cells can tolerate a much greater number of silver nanoparticles if they are encapsulated than if they are naked.
To this end, the researchers have developed, within the context of the National Research Programme “Smart Materials” (NRP 62), a one-pot synthesis process (*) to encapsulate the nanoparticles. This allows them to determine the porosity and the size of the silica container in relation to the nanoparticle it contains. Under the microscope, it looks like a nanoscopic rattle.
To improve the performance of the coating even further, the researchers - in collaboration with Prof Christian Bochet’s group - are also working on bacterial sensors which they aim to attach to the encapsulated nanoparticles. If such a sensor were in place, the silver would only be released if a pathogen were nearby. This targeted release would further prolong the efficiency of the protection and it would prevent silver from being needlessly released into the organism.
The synthesis developed by the researchers allows for the development of various types of containers for various nanoparticles. The application potential for these nano-rattles is therefore considerable: by con-trolling the porosity of the container, it is for example possible to con-trol which molecules can get close to the nanoparticles. This, in turn, would make it possible to create a nanoreactor in which a chemical reaction can take place. The technique might also enable new battery designs in which each encapsulated nanoparticle would play the role of an electrode.
National Research Programme “Smart Materials” (NRP 62)NRP 62 is a cooperation programme between the Swiss National Sci-ence Foundation (SNSF) and the Innovation Promotion Agency (CTI). The programme's aim is not only to promote scientific excellence but also to promote the successful industrial exploitation of smart materi-als and their application. NRP 62 also strives to link up the available skills and resources of various research institutions in Switzerland. The research work provides the technologies required to develop smart materials and the structures needed to integrate these. Having started its second phase at the beginning of 2013, NRP 62 now consists of 12 projects whose funding has been continued thanks to their high potential for practical application. NRP 62 will come to an end in 2015.
www.nrp62.ch(*) Magdalena Priebe et Katharina M. Fromm (2014). One-pot synthesis and catalytic properties of encapsulated nanoparticles in silica nanocontainers. Particle & Particle Systems Characterization online: doi:10.1002/ppsc.
(Journalists can order the article as a PDF from the SNSF: email@example.com)Contact
Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie
Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy