The paper will be made available online ahead of print at www.genesdev.org.
Innate immune cells, including macrophages, comprise a large fraction of the cellular environment that infiltrates tumors – the so-called "tumor microenvironment". Tumors have a dynamic relationship with their microenvironment, communicating via secreted factors to modulate cellular growth and cancer progression.
In their upcoming G&D paper, Dr. Joyce and colleagues delineate how tumor-associated macrophages (TAMs) promote tumor growth and invasion. The researchers found that macrophage cells infiltrating pancreatic, mammary and lung tumors produce high levels of the proteases cathepsin B and S (Cts B and S), which enhances tumor growth and invasion. Interestingly, the researchers discovered that increased Cts B and S activity is stimulated by the tumors, themselves - through the release of interleukin (IL)-4.
The study is highly anticipated because it provides novel and compelling evidence for the therapeutic targeting of the tumor microenvironment -- specifically TAMs -- to disrupt communication and ultimately impede cancer progression.
Dr. Joyce is optimistic that "the identification of factors that are differentially produced by conscripted cells in the tumor microenvironment provides a strategy to selectively target these cells in combination with targeting the cancer cells, an approach that could have significant therapeutic potential."
Closing the carbon loop
08.12.2016 | University of Pittsburgh
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
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