The paper will be made available online ahead of print at www.genesdev.org.
Innate immune cells, including macrophages, comprise a large fraction of the cellular environment that infiltrates tumors – the so-called "tumor microenvironment". Tumors have a dynamic relationship with their microenvironment, communicating via secreted factors to modulate cellular growth and cancer progression.
In their upcoming G&D paper, Dr. Joyce and colleagues delineate how tumor-associated macrophages (TAMs) promote tumor growth and invasion. The researchers found that macrophage cells infiltrating pancreatic, mammary and lung tumors produce high levels of the proteases cathepsin B and S (Cts B and S), which enhances tumor growth and invasion. Interestingly, the researchers discovered that increased Cts B and S activity is stimulated by the tumors, themselves - through the release of interleukin (IL)-4.
The study is highly anticipated because it provides novel and compelling evidence for the therapeutic targeting of the tumor microenvironment -- specifically TAMs -- to disrupt communication and ultimately impede cancer progression.
Dr. Joyce is optimistic that "the identification of factors that are differentially produced by conscripted cells in the tumor microenvironment provides a strategy to selectively target these cells in combination with targeting the cancer cells, an approach that could have significant therapeutic potential."
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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