Cells 'talk' to each other through a complex process called 'signalling'. When these signals go wrong, it can lead to all kinds of diseases, including cancer, diabetes and arthritis, to name but a few.
Scientists have long been able to see how cells send and receive signals at their outer skins, or membranes, but much of what happens afterwards has not been fully understood. As a result, many drugs on the market work without scientists knowing precisely how or what consequences they have for cell function.
Researchers at The University of Manchester in England have now developed a technique that will allow scientists to understand how these signals pass from the cell membrane into the cell itself, triggering a complex set of biological processes that have never been fully understood.
The research, published in the prestigious journal Science Signaling, will spark intense interest among the global scientific community, as they will hopefully lead to better drug design and faster drug delivery times. In addition, the findings will also provide biologists with a completely new insight into how our bodies work.
"Cell signalling is a fundamental biological process that is essential for life and when it goes wrong, disease results," said Professor Martin Humphries, lead researcher on the project and Dean of Manchester's Faculty of Life Sciences.
"Signals allow cells to 'taste' their environment in a similar fashion to how we taste food and drink. As an analogy, red wines have subtly different flavours, comprising a combination of hints of berries, oak, tobacco and liquorice. The same is true for cells that taste the thousands of molecules that make up their immediate environment.
"Our findings explain how cells might interpret these various flavours at a molecular level to generate an overall signal or taste. To do this, we have developed a technique that will allow scientists to examine how the receptors on the surface of cells pass information to the hundreds of proteins inside the cell that create the signal. Uniquely, our findings will allow scientists to look at all these hundreds of components at the same time."
The team's findings will finally allow scientists to observe how drugs work at an intracellular level, which will allow them to fully understand how they interact with the hundreds of cell receptors at the same time and what side-effects they are likely to produce.
Professor Humphries added: "Our findings will be of great interest to scientists and pharmaceutical companies as they open up new avenues for drug development and testing."
Aeron Haworth | EurekAlert!
Study identifies RNA molecule that shields breast cancer stem cells from immune system
23.05.2017 | Princeton University
“Pregnant” Housefly Males Demonstrate the Evolution of Sex Determination
23.05.2017 | Universität Zürich
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Earth Sciences
23.05.2017 | Life Sciences
23.05.2017 | Physics and Astronomy