Pioneering work by Roger Pocock, a newly arrived Group Leader at the research centre BRIC, University of Copenhagen, reveals the remarkable ability of organisms to activate latent neuronal circuits under stressful conditions. It is suggested that such circuits form part of an escape response that enables animals to sense their environment and adapt their behaviour under unfavourable conditions. This work is being published in the journal Nature Neuroscience on April 18 th*.
The human brain contains billions of neurons that build trillions of connections making it very complex to study behaviour at the level of the single neuron. Therefore, the Pocock laboratory uses the simple nervous system of the microscopic worm, Caenorhabditis elegans, to model how our environment modifies gene function, neuronal circuitry and behaviour. Using C. elegans, which contains just 302 neurons, Dr Pocock has identified a hidden neuronal circuit that modulates sensory perception under stress. Specifically, this work discovered that physiological detection of hypoxic (low oxygen) stress results in the activation of a hidden neuronal circuit involving the neuromodulators serotonin and the neuropeptide Y receptor.
This work implicates that mechanisms coupling hypoxia, serotonin and neuropeptide signaling also modifies behaviour in mammals. In fact, hypoxic stress enhances serotonin and neuropeptide production in specific regions of the mammalian brain, however, the functional output of this is poorly understood.
Roger Pocock did the experiments for this article at Columbia University, New York, where he worked as a researcher before coming to Denmark. He has previously published novel findings in Nature Neuroscience and his strong research potential within this field was essential for his recruitment as a Group Leader at BRIC.
"These and other studies in the burgeoning field of environment-gene-neuron interactions will hopefully enable us to better understand how to cope with stress in our every-changing and busy lives" says Roger Pocock.
As Charles Darwin himself said 'Man is but a worm'!
* Hypoxia activates a latent circuit for processing gustatory information in C. elegans. Roger Pocock & Oliver Hobert.
Katrine Sonne-Hansen | EurekAlert!
‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie
Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Earth Sciences
24.10.2016 | Life Sciences
24.10.2016 | Physics and Astronomy