The individual classic markers for milk quality control, particularly protein concentration, are easy to be manipulated and it is difficult to use these markers to monitor the raw milk content in formula milk and various milk products. The findings, published this week in Cell Research, could lead to a completely new standard for milk quality control, and possible new milk products with specific usage in the future.
The research group, led by Drs. Chen-Yu Zhang and Ke Zen at Nanjing University School of Life Sciences, found that cow milk contains large amount of microRNAs (miRNAs), a 19-23nt in length non-coding RNA, and the unique expression profile of milk-specific miRNAs can serve as a novel indicator and possible new standard for the quality control of raw milk and milk-related commercial products, such as fluid milk and powdered formula milk. Through systematic analysis of milk miRNA in milk via Solexa sequencing and real time qRT-PCR, they found that miRNA profiling was different at various stage of lactation. Compared to the previous finding by the same group that serum miRNAs serve as non-invasive fingerprint for cancer or other disease, the current study shows that cow milk contains milk-specific miRNAs and their concentrations are generally higher than those in serum. Seven milk-enriched miRNAs have been selected and their levels are proportionally correlated to the content of raw milk. "Compared to traditional indicator for milk", said by Professor Zhang, "milk miRNA-based biomarker provides much more accurate tool for milk quality control because this biomarker contains multiple miRNAs, and these miRNAs acturally reflect the various property of milk".
Besides serving as new indicator for milk content, finding functional miRNAs in milk may also change our understanding of nutrient in milk-related product. Added by Professor Ke Zen, "if we can identify the biological function of various miRNA in milk, by removing or adding certain miRNA, we may generate new milk products specialized for certain people groups".
The researchers of this project include Xi Chen1, Chao Gao1, Haijin Li1, Lei Huang1, Qi Sun1, Yanye Dong1, Chunliang Tian2, Shengpu Gao3, Hailin Dong2, Danping Guan2, Xiaoyun Hu2, Shujian Zhao2, Liang Li1, Lin Zhu1, Qiao Yan1, Junfeng Zhang1, Ke Zen1, and Chen-Yu Zhang1 of 1Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, China; 2Nanjing MicroMedMark Biotech Co., Ltd., 88 Zhujiang Road, Nanjing, Jiangsu 210008, China; 3China National Institute of Standardization, 4 ZhiChun Road, HaiDian District, Beijing 100088, China.
This work was supported by grants from the National Natural Science Foundation of China (no. 30225037, 30471991, 30570731), the 973 Program of China (no. 2006CB503909, 2004CB518603), the "111" Project, the Natural Science Foundation of Jiangsu Province (no. BK2004082, BK2006714)
Chen et al.: "Identification and characterisation of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products" Publishing on Cell Research, June 15, 2010.
Author contact: Chen-Yu Zhang (School of Life Sciences, Nanjing University, Nanjing, China) Tel: +86 25 8368 6234; E-mail: firstname.lastname@example.org
Editorial contact: Dangsheng Li (Cell Research, Shanghai, China) Tel: +86 21 5492 2951; E-mail: email@example.com
Zhang Liwei | EurekAlert!
Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University
Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering