The findings published ahead of print in the ERJ suggest that FeNO may be a useful biomarker for identifying children at risk for the disease, and in developing strategies for preventing asthma. Researchers found that children with the highest levels of FeNO were more than twice as likely to develop asthma compared to those with the lowest levels. Higher levels of FeNO were linked with development of asthma most often in children whose parents had no history of the disease.
Nitric oxide is a gas that is produced by the cells that line the inner wall of the lungs’ airways, and may be a marker of the inflammatory process that occurs in the lungs prior to asthma onset. Although a number of studies have documented the growing prevalence of asthma during the past several decades, the factors causing the rapid rise of the disease are not fully understood.
“We believe this is the first study to demonstrate the predictive value of FeNO for identifying children who are at risk for developing asthma,” said Tracy Bastain, M.P.H., a doctoral student in the Department of Preventive Medicine at the Keck School of Medicine and the lead author of the study. “Our results were strongest in children whose parents had never had asthma, suggesting that FeNO might help to identify additional susceptible children.”
The USC study drew upon data from the Children’s Health Study (CHS), the longest epidemiologic investigation ever conducted on environmental contribution to children’s respiratory health. In 2004, USC researchers measured the level of FeNO in 2,206 healthy, asthma-free children from 13 communities in Southern California. Between 2004 and 2007, they tracked the respiratory health of the children with annual follow-up questionnaires.
Previous studies have found that FeNO is elevated in children with current asthma or allergies. However, researchers at USC were able to draw upon a large cohort of healthy children to identify FeNO as a potential biomarker for asthma development, Bastain said. Further studies are needed to establish whether FeNO can be used in the clinical setting to assess a child’s individual risk for developing asthma.
“Asthma is a very important clinical and public health problem, and there is still much to be learned about the causes of asthma before the burden of asthma can be reduced,” said Frank Gilliland, M.D., Ph.D., professor of preventive medicine at the Keck School of Medicine, director of the Southern California Environmental Health Sciences Center and senior author of the study. “Showing a link between FeNO and later asthma development provides new clues to the development of asthma.”
The study was funded by the National Institute of Environmental Health Sciences, the National Heart, Lung and Blood Institute, the Environmental Protection Agency, and the Hastings Foundation.
Title of the original article: “Exhaled Nitric Oxide, Susceptibility and New-Onset Asthma in the Children`s Health Study.”
Dr. Anka Stegmeier-Petroianu | idw
For a chimpanzee, one good turn deserves another
27.06.2017 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)
New method to rapidly map the 'social networks' of proteins
27.06.2017 | Salk Institute
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
27.06.2017 | Power and Electrical Engineering
27.06.2017 | Information Technology
27.06.2017 | Physics and Astronomy