The feedback loop of transcriptional factor with 24 h period in the suprachiasmatic nuclei (SCN) was proposed to work as a circadian central oscillator, as well as in peripheral tissues including cartilage and bone.
On the other hand, the fundamental architecture of skeletal patterning is regulated by ultradian clocks that undergo cycles more than once every 24 hours in embryonic development. In 1997, the oscillatory expression of c-hairy1—a Notch effecter gene—was identified in chick embryos and matched the period of somite formation (every 90 minutes in chicks), called the segmentation clock.
Somitogenesis is one of the most evident events in an ultradian manner, which endows basic repetitive patterns of axial skeleton and its associated tissues during embryonic development. Long bone growth and bone metabolism also exhibit periodic activities in a circadian fashion. Core loops of circadian clock genes are also at work in bone and cartilage.
Here, collaborators at Toyohashi University of Technology and Tokyo Medical and Dental University propose bio-imaging methodology to observe both clocks. Bio-imaging detecting of luminescent and fluorescent signals enables observation of more comprehensive sets of genes and spatio-temporal regulation of these clockwork machineries during development.
In this review paper, the authors also describe the potential of three dimensional imaging for bone research. Topics covered include molecular clocks in skeletal biology and medicine, and how fluorescence imaging would contribute to widening our knowledge of biomedical science.
Tadahiro Iimura*1, Ayako Nakane1, Mayu Sugiyama1, Hiroki Sato1, Yuji Makino, Takashi Watanabe1 , Yuzo Takagi1, Rika Numano*2 , Akira Yamaguchi*1*to whom correspondence should be addressedA fluorescence spotlight on the clockwork development and metabolism of boneJournal of Bone and Mineral Metabolism On line July 2011DOI: 10.1007/s00774-011-0295-31International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental
University, Sections of Oral PathologyWebsite: http://www.tmd.ac.jp/dent/opat/opat-J.htm2The Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology Website: http://www.eiiris.tut.ac.jp/
Rika Numano | Toyohashi University
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy