Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bio-imaging offers insights into the relationship between circadian and ultradian rhythms.

19.09.2011
Living things have rhythms—for example, body temperature rhythms and segmentation clock. In the late 1990s, several clock genes were cloned to elucidate the functions and interactions of rhythms.

The feedback loop of transcriptional factor with 24 h period in the suprachiasmatic nuclei (SCN) was proposed to work as a circadian central oscillator, as well as in peripheral tissues including cartilage and bone.

On the other hand, the fundamental architecture of skeletal patterning is regulated by ultradian clocks that undergo cycles more than once every 24 hours in embryonic development. In 1997, the oscillatory expression of c-hairy1—a Notch effecter gene—was identified in chick embryos and matched the period of somite formation (every 90 minutes in chicks), called the segmentation clock.

Somitogenesis is one of the most evident events in an ultradian manner, which endows basic repetitive patterns of axial skeleton and its associated tissues during embryonic development. Long bone growth and bone metabolism also exhibit periodic activities in a circadian fashion. Core loops of circadian clock genes are also at work in bone and cartilage.

Here, collaborators at Toyohashi University of Technology and Tokyo Medical and Dental University propose bio-imaging methodology to observe both clocks. Bio-imaging detecting of luminescent and fluorescent signals enables observation of more comprehensive sets of genes and spatio-temporal regulation of these clockwork machineries during development.

In this review paper, the authors also describe the potential of three dimensional imaging for bone research. Topics covered include molecular clocks in skeletal biology and medicine, and how fluorescence imaging would contribute to widening our knowledge of biomedical science.

Tadahiro Iimura*1, Ayako Nakane1, Mayu Sugiyama1, Hiroki Sato1, Yuji Makino, Takashi Watanabe1 , Yuzo Takagi1, Rika Numano*2 , Akira Yamaguchi*1*to whom correspondence should be addressedA fluorescence spotlight on the clockwork development and metabolism of boneJournal of Bone and Mineral Metabolism On line July 2011DOI: 10.1007/s00774-011-0295-31International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental

University, Sections of Oral PathologyWebsite: http://www.tmd.ac.jp/dent/opat/opat-J.htm2The Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology Website: http://www.eiiris.tut.ac.jp/

Rika Numano | Toyohashi University
Further information:
http://www.tut.ac.jp/english/newsletter/research_highlights/research02.html

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>