Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A glimpse into the genetic basis of schizophrenia

25.07.2014

Novel genetic associations might enlighten underlying molecular mechanisms of schizophrenia and provide biomarkers for future diagnosis

For schizophrenia, biomarkers or supportive diagnostic tests are scarce and for many patients the efficacy of pharmacological treatment is limited. The PGC-SZ (Psychiatric Genomics Consortium - Schizophrenia), including scientists from the Max Planck Institute of Psychiatry in Munich, has now identified more than 100 genetic loci related to schizophrenia.


Artistic view of how life feels after the diagnosis of schizophrenia.

© Glen Brady, Queensland Centre for Mental Health Research

The results point to molecules that are currently the most promising targets for therapeutics also aligning well with recent theories about factors causing schizophrenia. The novel findings provide a relevant foundation for mechanistic and treatment development studies.

Schizophrenia is known to be a heritable disorder, highlighting inherited genetic variants to be a key causative for this disease. Due to the scarcity of biomarkers or supportive diagnostic tests, diagnosis is almost exclusively clinician-based. Furthermore, although pharmacological treatments are available for schizophrenia, their efficacy is limited for many patients.

The PGC-SZ, including Bertram Müller-Myhsok, Research Group Leader at the Max Planck Institute of Psychiatry in Munich, has now performed a genome-wide association study and identified more than 100 genomic loci that are significantly related to schizophrenia.

“Our findings include molecules that are currently the most promising targets for therapeutics and point to molecular systems aligning with the predominant theories on factors causing schizophrenia,” states Bertram Müller-Myhsok. “This might suggest that the many novel findings we report also provide a relevant foundation for treatment development studies.”

Particularly variations in genes related to altered glutamatergic synaptic and calcium channel function might serve as a panel of biomarkers for future diagnosis of schizophrenia or might allow better understanding of the molecular mechanisms underlying the disease.

Such associations with genes playing a role in the central nervous system are most relevant for the development of treatment strategies. The results of the study verified genetic associations with the gene coding for the type 2 dopaminergic receptor (DRD2).

“All available antipsychotic drugs are thought to exert their main therapeutic effects through blockade of DRD2,” explains Bertram Müller-Myhsok. “Since the discovery of this mechanism over 60 years ago, no new antipsychotic drug of proven efficacy has been developed based on other target molecules.” Thus, therapeutic stasis is in large part a consequence of the fact that the disease-causing mechanisms are still unknown. Identifying the causes of schizophrenia is therefore a critical step towards improving treatment and outcome for patients suffering from this disorder.

Contact 

Dr. Bertram Müller-Myhsok

Max Planck Institute of Psychiatry, München

Phone: +49 89 30622-246

 

Anna Niedl

Press and Public Relations

Max Planck Institute of Psychiatry, München

Phone: +49 89 30622-263
Fax: +49 89 30622-370

 

Original publication

 
Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Biological insights from 108 schizophrenia-associated genetic loci.
Nature, 22. Juli 2014 (doi:10.1038/nature13595)AN/HR

Dr. Bertram Müller-Myhsok | Max-Planck-Institute

Further reports about: Psychiatry biomarkers disorder findings mechanisms schizophrenia therapeutic

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>