The award, which comes with a $5,000 cash prize, was presented during the 101st annual meeting of the American Association for Cancer Research, at which Mendell delivered a lecture, “MicroRNA Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities.” His recent research demonstrates that the delivery of microRNAs to cancer cells represents a promising strategy for cancer therapy.
“To be included among the incredible past recipients of this award — many of whom I view as scientific role models — is truly humbling and very exciting,” Mendell says. “This recognition suggests that our work has addressed important scientific questions that have had a broad impact on the cancer research community, and provides inspiration to continue to investigate fundamental questions in cancer biology.”
Mendell’s research focuses on short pieces of RNA that do not encode protein but control genes. These small molecules can act as either cancer-driving oncogenes or as tumor-suppressor genes, which prevent cells from becoming cancerous. Mendell’s laboratory is studying microRNAs in human cells and in animals such as zebrafish and mice to understand how aberrant miRNA activity contributes to cancer and to develop miRNA-based therapeutic strategies.
Mendell earned both his medical degree (2003) and a Ph.D. (2001) at Johns Hopkins before starting his lab there. He has received a number of awards and recognitions, including being named the Outstanding Young Scientist in the State of Maryland (Allan C. Davis Medal), 2007; a “Top Young Investigator of 2007” by Genome Technology Magazine, 2007; a Leukemia and Lymphoma Society Scholar, 2008; and a Howard Hughes Medical Institute Early Career Scientist, 2009.
“We are proud that the AACR has chosen to recognize Josh for his outstanding work,” says David Valle, M.D., the Henry J. Knott Professor and Director of the Institute for Genetic Medicine. “The microRNA field has really taken off, and Josh has been there to set the bar.”
This year’s AACR meeting, themed “Conquering Cancer Through Discovery Research,” highlighted novel approaches and technologies being used in the laboratory, innovative preclinical science and clinical trials. As the premier scientific meeting in cancer research, it attracts over 17,000 attendees annually and covers the breadth of cancer science from basic through clinical and epidemiological research.
“AACR member scientists are making great strides in basic, translational and clinical research, as well as population science and prevention,” says Margaret Foti, Ph.D., M.D., chief executive officer of the AACR. “Their work is having an enormous impact on the pace of discovery. We are extremely proud to honor their outstanding work because these achievements are saving lives around the world.”On the Web:
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The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
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17.11.2017 | Physics and Astronomy
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17.11.2017 | Studies and Analyses