The German Federal Ministry of Education and Research (BMBF) will be supplying the ZiSStrans research consortium with around four million euros over the next five years. The joint project, which is being coordinated at the Helmholtz Zentrum München, has the objective of investigating new possibilities to personalize radiotherapy of head and neck cancer.
The term ‘head-neck cancer’ is used to refer to various tumor types that occur in this part of the body, for example, cancer of the oral cavity or pharynx. Radiotherapy, either alone or combined with surgery and/or chemotherapy, is a central element in the complex treatment strategies.
Difficulties arise, however, if the tumors demonstrate so-called radiation resistance and do not respond to the treatment as desired, or if undesirable effects occur that make it necessary to stop the treatment.
“This is where the ZiSStrans project comes in,” explains coordinator Prof. Dr. Horst Zitzelsberger, head of the Radiation Cytogenetics Research Unit at the Helmholtz Zentrum München. “Our objective is to identify molecular signaling pathways and target structures for the radiation response and to examine them in patient studies.”
In this field, this step is called translation, which also explains the project's name. Because ZiSStrans is the translational follow-up project of “Targets and signaling pathways of radiation hypersensitivity and resistance” or ZiSS for short, which ran from 2012 to 2017.
The researchers particularly hope to gain new insights by comparing tumor and normal tissue. “The radiosensitivity of the surrounding healthy tissue limits the radiotherapy intensity which can be applied, because this is where undesirable effects can occur,” Zitzelsberger explains.
By understanding the signaling networks in the tumor and normal tissue, the researchers want to explore how the radiation response and resistance can be selectively influenced and how the treatment success can be improved by molecular substances.
A further focus of the research consortium is on personalized treatment. The use of new markers should make it possible to predict whether or not the particular patient will be able to profit from the planned action, even before the first radiation treatment. “In the future, we want to be able to say with great certainty that a particular patient is either a ‘responder’ or a ‘non-responder’, which means if the patient will respond to the treatment or if other options must be considered in advance,” says coordinator Zitzelsberger.
Of the total of four million euros that the BMBF will be providing to the project between 2017 and 2022, around 800,000 will be allocated to the Helmholtz Zentrum München. In addition to Research Unit Head Zitzelsberger, the groups of Dr. Julia Heß and Dr. Kristian Unger are also involved. Furthermore, the following partners are participating in the project:
• University Hospital of Munich (LMU, Department for Radiotherapy and Radiation Oncology, Prof. Lauber, Prof. Belka)
• Essen University Hospital (Institute of Cell Biology, Prof. Jendrossek, PD Dr. Klein)
• Medical Center – University of Freiburg (Center for Diagnostic and Therapeutic Radiology, Prof. Henke)
• Charité University Hospital Berlin (Institute of Pathology, Prof. Blüthgen)
• German Federal Office for Radiation Protection Neuherberg (Biological Radiation Effects, Dr. Hornhardt, Dr. Gomolka)
• Clinical cooperation group "Personalized radiotherapy of head-neck tumors" involving the Department for Radiotherapy and Radiation Oncology, University Hospital of Munich (LMU) and the Radiation Cytogenetics Research Unit, Helmholtz Zentrum München
Almost one year ago, researchers in the consortium had already developed a new method of predicting disease progression of certain brain tumors after standard treatment. In the journal ‘Oncotarget’, they were able to show that four miRNAs can provide the crucial indications. A direct application for a corresponding patent has already been made: https://www.helmholtz-muenchen.de/en/press-media/press-releases/all-press-releas...
In the thyroid gland, the researchers have also been able to identify markers for tumors induced by radiation: https://www.helmholtz-muenchen.de/en/press-media/press-releases/all-press-releas...
The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members. http://www.helmholtz-muenchen.de/en
The Research Unit Radiation Cytogenetics (ZYTO) investigates radiation-induced chromosome and DNA damage in cell systems and human tumours. The focus is on clarifying the mechanisms associated with radiation-induced carcinogenesis and radiation sensitivity of tumour cells. The aim of this research is to find biomarkers associated with radiation-induced tumours in order to develop personalized radiation therapy for the stratification of patients. ZYTO is a part of the Department of Radiation Sciences (DRS). http://www.helmholtz-muenchen.de/zyto
Contact for the media:
Department of Communication, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg - Tel. +49 89 3187 2238 - E-mail: email@example.com
Scientific Contact at Helmholtz Zentrum München:
Prof. Dr. Horst Zitzelsberger, Helmholtz Zentrum München - German Research Center for Environmental Health, Research Unit Radiation Cytogenetics, Ingolstädter Landstr. 1, 85764 Neuherberg - Tel. +49 89 3187 3421, E-mail: Zitzelsberger@helmholtz-muenchen.de
Sonja Opitz | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)
ERC Project set to boost application of adhesive structures
19.03.2018 | INM - Leibniz-Institut für Neue Materialien gGmbH
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy