TiHo scientists unravel genes responsible for canine hip dysplasia.
Canine hip dysplasia (CHD) plays a central role in the selection of breeding animals ever since modern dog breeding began. This inherited condition is common in all dog breeds as well as in mongrels. Researchers at the Institute for Animal Breeding and Genetics at the University of Veterinary Medicine Hannover Foundation (TiHo), has identified important genetic variants and their interrelated pathways for the pathogenesis of CHD in German Shepherds.
Canine hip dysplasia is common in all dog breeds as well as in mongrels.
The scientists genotyped more than 1000 German Shepherds and screened a large number of single nucleotide polymorphisms (SNPs) for their association with CHD. Professor Dr. Ottmar Distl and his doctoral student Lena Fels have published their research results in the international online journal PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0096618).
CHD is caused by a malformation and instability of the hip joints. The first attempts to breed against CHD started at the end of the 1960s due to the severity of this disease and its general significance for the health of dogs. The sole basis of the breeding programs was X-rays of both hip joints. Dogs with significant and severe changes were excluded from breeding. Systematic preventative programs have been established by most dog breeding associations and have become an integral part of the selection programs in purebred dog breeding.
The genetic mechanisms responsible for CHD involve the formation of cartilage and bone. The metabolic pathways show significant similarities with osteoarthritis and chondrodysplasia in humans. “Research of CHD is of fundamental importance in terms of understanding the processes that can lead to osteoarthritis in humans”, says Distl, head of the Institute for Animal Breeding and Genetics at TiHo.
Dog breeding will significantly benefit from the research. “Despite the use of estimated breeding values (EBVs) for CHD, dogs affected with CHD are not uncommon and often unexpected according to the parental EBVs. This presents large problems for dog breeders. Handling of CHD-affected dogs is often difficult and dogs frequently suffer from the painful condition”, says Fels. Using these new results, CHD can be prevented much more effectively. Simulation studies using real population parameters and the new approach have demonstrated its superiority over traditional methods.
The genome-wide CHD-test is now available at the Institute for Animal Breeding and Genetics at TiHo and can be provided to all breeders and owners of German Shepherds. Further details can be found on the homepage of the Institute for Animal Breeding and Genetics (www.tiho-hannover.de/kliniken-institute/institute/institut-fuer-tierzucht-und-vererbungsforschung/). Similar genome-wide tests have already been developed for Bernese Mountain dogs. The research on Bernese Mountain dogs was published in December 2012 at PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0049782).
Future work by TiHo geneticists will focus on genome-wide, next-generation sequencing of dog samples. The objective is to sequence the entire genome for a large number of dogs of different breeds in order to detect polymorphisms and structural variants. This will enable us to compare CHD-affected dogs with dogs free of any signs of CHD and that show a very low risk for CHD in their progeny. “Using this approach, we will be in the position to map the CHD-associated mutations and provide new insights into the pathogenesis of CHD. As such, our research will be able to be extended to include many more different dog breeds”, says Distl.
The original publication
Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs
Lena Fels, Ottmar Distl
PLOS ONE, DOI: 10.137/ journal.pone.0096618
For specialised queries, please contact:
Professor Dr. Ottmar Distl
University of Veterinary Medicine Hannover
Institute for Animal Breeding and Genetics
Tel.: +49 511 953-8875
Sonja von Brethorst | idw - Informationsdienst Wissenschaft
Crop advances grow with protection
28.04.2016 | American Society of Agronomy
Can urban gardeners benefit ecosystems while keeping food traditions alive?
06.04.2016 | University of Illinois College of Agricultural, Consumer and Environmental Sciences
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.
Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...
As one of the leading R&D partners in the development of surface technologies and organic electronics, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP will be exhibiting its recent achievements in vacuum coating of ultra-thin glass at SVC TechCon 2016 (Booth 846), taking place in Indianapolis / USA from May 9 – 13.
Fraunhofer FEP is an experienced partner for technological developments, known for testing the limits of new materials and for optimization of those materials...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
29.04.2016 | Physics and Astronomy
29.04.2016 | Health and Medicine
29.04.2016 | Life Sciences