TiHo scientists unravel genes responsible for canine hip dysplasia.
Canine hip dysplasia (CHD) plays a central role in the selection of breeding animals ever since modern dog breeding began. This inherited condition is common in all dog breeds as well as in mongrels. Researchers at the Institute for Animal Breeding and Genetics at the University of Veterinary Medicine Hannover Foundation (TiHo), has identified important genetic variants and their interrelated pathways for the pathogenesis of CHD in German Shepherds.
Canine hip dysplasia is common in all dog breeds as well as in mongrels.
The scientists genotyped more than 1000 German Shepherds and screened a large number of single nucleotide polymorphisms (SNPs) for their association with CHD. Professor Dr. Ottmar Distl and his doctoral student Lena Fels have published their research results in the international online journal PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0096618).
CHD is caused by a malformation and instability of the hip joints. The first attempts to breed against CHD started at the end of the 1960s due to the severity of this disease and its general significance for the health of dogs. The sole basis of the breeding programs was X-rays of both hip joints. Dogs with significant and severe changes were excluded from breeding. Systematic preventative programs have been established by most dog breeding associations and have become an integral part of the selection programs in purebred dog breeding.
The genetic mechanisms responsible for CHD involve the formation of cartilage and bone. The metabolic pathways show significant similarities with osteoarthritis and chondrodysplasia in humans. “Research of CHD is of fundamental importance in terms of understanding the processes that can lead to osteoarthritis in humans”, says Distl, head of the Institute for Animal Breeding and Genetics at TiHo.
Dog breeding will significantly benefit from the research. “Despite the use of estimated breeding values (EBVs) for CHD, dogs affected with CHD are not uncommon and often unexpected according to the parental EBVs. This presents large problems for dog breeders. Handling of CHD-affected dogs is often difficult and dogs frequently suffer from the painful condition”, says Fels. Using these new results, CHD can be prevented much more effectively. Simulation studies using real population parameters and the new approach have demonstrated its superiority over traditional methods.
The genome-wide CHD-test is now available at the Institute for Animal Breeding and Genetics at TiHo and can be provided to all breeders and owners of German Shepherds. Further details can be found on the homepage of the Institute for Animal Breeding and Genetics (www.tiho-hannover.de/kliniken-institute/institute/institut-fuer-tierzucht-und-vererbungsforschung/). Similar genome-wide tests have already been developed for Bernese Mountain dogs. The research on Bernese Mountain dogs was published in December 2012 at PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0049782).
Future work by TiHo geneticists will focus on genome-wide, next-generation sequencing of dog samples. The objective is to sequence the entire genome for a large number of dogs of different breeds in order to detect polymorphisms and structural variants. This will enable us to compare CHD-affected dogs with dogs free of any signs of CHD and that show a very low risk for CHD in their progeny. “Using this approach, we will be in the position to map the CHD-associated mutations and provide new insights into the pathogenesis of CHD. As such, our research will be able to be extended to include many more different dog breeds”, says Distl.
The original publication
Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs
Lena Fels, Ottmar Distl
PLOS ONE, DOI: 10.137/ journal.pone.0096618
For specialised queries, please contact:
Professor Dr. Ottmar Distl
University of Veterinary Medicine Hannover
Institute for Animal Breeding and Genetics
Tel.: +49 511 953-8875
Sonja von Brethorst | idw - Informationsdienst Wissenschaft
Harnessing a peptide holds promise for increasing crop yields without more fertilizer
25.11.2015 | University of Massachusetts at Amherst
Study shows how crop prices and climate variables affect yield and acreage
18.11.2015 | University of Illinois College of Agricultural, Consumer and Environmental Sciences
Before the fluid of the middle ear drains and sound waves penetrate for the first time, the inner ear cells of newborn rodents practice for their big debut. Researchers at Johns Hopkins report they have figured out the molecular chain of events that enables the cells to make “sounds” on their own, essentially “practicing” their ability to process sounds in the world around them.
The researchers, who describe their experiments in the Dec. 3 edition of the journal Cell, show how hair cells in the inner ear can be activated in the absence...
Planet Earth experienced a global climate shift in the late 1980s on an unprecedented scale, fuelled by anthropogenic warming and a volcanic eruption, according to new research published this week.
Scientists say that a major step change, or ‘regime shift’, in the Earth’s biophysical systems, from the upper atmosphere to the depths of the ocean and from...
The Fraunhofer Institute for Solar Energy Systems ISE has installed 70 photovoltaic modules on the outer façade of one of its lab buildings. The modules were...
Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.
In comparison to other organs, the human brain has the highest energy requirements. The supply of energy for nerve cells and the particular role of lactic acid...
In laser material processing, the simulation of processes has made great strides over the past few years. Today, the software can predict relatively well what will happen on the workpiece. Unfortunately, it is also highly complex and requires a lot of computing time. Thanks to clever simplification, experts from Fraunhofer ILT are now able to offer the first-ever simulation software that calculates processes in real time and also runs on tablet computers and smartphones. The fast software enables users to do without expensive experiments and to find optimum process parameters even more effectively.
Before now, the reliable simulation of laser processes was a job for experts. Armed with sophisticated software packages and after many hours on computer...
30.11.2015 | Event News
25.11.2015 | Event News
17.11.2015 | Event News
30.11.2015 | Trade Fair News
30.11.2015 | Trade Fair News
30.11.2015 | Trade Fair News