TiHo scientists unravel genes responsible for canine hip dysplasia.
Canine hip dysplasia (CHD) plays a central role in the selection of breeding animals ever since modern dog breeding began. This inherited condition is common in all dog breeds as well as in mongrels. Researchers at the Institute for Animal Breeding and Genetics at the University of Veterinary Medicine Hannover Foundation (TiHo), has identified important genetic variants and their interrelated pathways for the pathogenesis of CHD in German Shepherds.
Canine hip dysplasia is common in all dog breeds as well as in mongrels.
The scientists genotyped more than 1000 German Shepherds and screened a large number of single nucleotide polymorphisms (SNPs) for their association with CHD. Professor Dr. Ottmar Distl and his doctoral student Lena Fels have published their research results in the international online journal PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0096618).
CHD is caused by a malformation and instability of the hip joints. The first attempts to breed against CHD started at the end of the 1960s due to the severity of this disease and its general significance for the health of dogs. The sole basis of the breeding programs was X-rays of both hip joints. Dogs with significant and severe changes were excluded from breeding. Systematic preventative programs have been established by most dog breeding associations and have become an integral part of the selection programs in purebred dog breeding.
The genetic mechanisms responsible for CHD involve the formation of cartilage and bone. The metabolic pathways show significant similarities with osteoarthritis and chondrodysplasia in humans. “Research of CHD is of fundamental importance in terms of understanding the processes that can lead to osteoarthritis in humans”, says Distl, head of the Institute for Animal Breeding and Genetics at TiHo.
Dog breeding will significantly benefit from the research. “Despite the use of estimated breeding values (EBVs) for CHD, dogs affected with CHD are not uncommon and often unexpected according to the parental EBVs. This presents large problems for dog breeders. Handling of CHD-affected dogs is often difficult and dogs frequently suffer from the painful condition”, says Fels. Using these new results, CHD can be prevented much more effectively. Simulation studies using real population parameters and the new approach have demonstrated its superiority over traditional methods.
The genome-wide CHD-test is now available at the Institute for Animal Breeding and Genetics at TiHo and can be provided to all breeders and owners of German Shepherds. Further details can be found on the homepage of the Institute for Animal Breeding and Genetics (www.tiho-hannover.de/kliniken-institute/institute/institut-fuer-tierzucht-und-vererbungsforschung/). Similar genome-wide tests have already been developed for Bernese Mountain dogs. The research on Bernese Mountain dogs was published in December 2012 at PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0049782).
Future work by TiHo geneticists will focus on genome-wide, next-generation sequencing of dog samples. The objective is to sequence the entire genome for a large number of dogs of different breeds in order to detect polymorphisms and structural variants. This will enable us to compare CHD-affected dogs with dogs free of any signs of CHD and that show a very low risk for CHD in their progeny. “Using this approach, we will be in the position to map the CHD-associated mutations and provide new insights into the pathogenesis of CHD. As such, our research will be able to be extended to include many more different dog breeds”, says Distl.
The original publication
Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs
Lena Fels, Ottmar Distl
PLOS ONE, DOI: 10.137/ journal.pone.0096618
For specialised queries, please contact:
Professor Dr. Ottmar Distl
University of Veterinary Medicine Hannover
Institute for Animal Breeding and Genetics
Tel.: +49 511 953-8875
Sonja von Brethorst | idw - Informationsdienst Wissenschaft
Faba fix for corn's nitrogen need
11.04.2018 | American Society of Agronomy
Wheat research discovery yields genetic secrets that could shape future crops
09.04.2018 | John Innes Centre
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Earth Sciences
23.04.2018 | Trade Fair News
23.04.2018 | Information Technology