Polysaccharides from Angelica sinensis alleviate oxidative damage to neurons
Under a laser scanning confocal microscopy, perfused microvessels were abundant after treatment with Angelica sinensis polysaccharide. Credit: Neural Regeneration Research
Recent studies have shown that extracts of Angelica sinensis have antioxidative and neuroprotective effects.
However, the anti-oxidative function of Angelica sinensis polysaccharide has rarely been addressed.
In a preliminary experiment from Dr. Tao Lei and colleagues from Zhongnan Hospital of Wuhan University in China, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment.
In a rat model of local cerebral ischemia, they further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia.
Their findings, published in the Neural Regeneration Research (Vol. 9, No. 3, 2014), highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.
Article: ” Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress,” by Tao Lei1, Haifeng Li2, Zhen Fang1, Junbin Lin1, Shanshan Wang1, Lingyun Xiao2, Fan Yang2, Xin Liu2, Junjian Zhang1, Zebo Huang2, Weijing Liao1 (1 Department of Rehabilitation Medicine, Zhongnan Hospital and Cerebral Vascular Diseases Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China; 2 School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei Province, China)
Lei T, Li HF, Fang Z, Lin JB, Wang SS, Xiao LY, Yang F, Liu X, Zhang JJ, Huang ZB, Liao WJ. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress. Neural Regen Res. 2014;9(3):260-267.
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
http://www.nrronline.org/
Media Contact
All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Newest articles
Trotting robots reveal emergence of animal gait transitions
A four-legged robot trained with machine learning by EPFL researchers has learned to avoid falls by spontaneously switching between walking, trotting, and pronking – a milestone for roboticists as well…
Innovation promises to prevent power pole-top fires
Engineers in Australia have found a new way to make power-pole insulators resistant to fire and electrical sparking, promising to prevent dangerous pole-top fires and reduce blackouts. Pole-top fires pose…
Possible alternative to antibiotics produced by bacteria
Antibacterial substance from staphylococci discovered with new mechanism of action against natural competitors. Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers…
