Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Systems Biology in Nephrology:  SysKid Researchers at the European Renal Congress Reveal a Picture of Complex and Dynamic

25.06.2010
At the Congress of the European Renal Association taking place in Munich from 25 to 28 June 2010 scientists from the large integrated EU research project SysKid will provide an overview of how research strategies known as »omics« for short can be used in nephrology.

»Omics« can, for instance, help researchers analyse the genome or all the proteins contained in a cell. Together with clinical and epidemiological findings these data provide not only new insights into renal function but also pave the way for the development of new strategies to combat chronic kidney disease.

The flow of data from the laboratories of geneticists and molecular biologists has grown into a flood in recent years. The twenty-five groups of researchers from fifteen countries who have been working together for the past five months on a large integrated research project known by the acronym SysKid aim to use the instruments of systems biology to channel and link these data in the field of nephrology and thus allow them to be utilised for medical research.

Genomics

»So-called association studies have in recent years allowed numerous genes to be discovered that play in a role in the development of chronic kidney disease«, Professor Rainer Oberbauer from the Medical University Vienna explains. The impact of these genes varies, how-ever. They have a mutual effect on one another and are also influenced by external factors – in other words, they display the typical traits of a »multi-factor disease«. The processes that lead to chronic kidney disease are much more complex than is generally assumed. Not least for this reason the predictability of how kidney disease will progress and how it will respond to treatment is limited. »Our goal must therefore be to diagnose the processes that cause the disease in an individual patient so that we can target treatment more precisely”, Oberbauer says.

Transcriptomics

»Analysis of the genetic information transcribed in the genetic transmitter RNA clearly shows that thinking of disease in terms of single factors – one gene is responsible for each disease – makes no sense for the overwhelming majority of diseases«, says Prof. Dr. Gert Mayer from the Medical University Innsbruck. »What actually happens is that whole networks change«, the nephrologist continues. »We can assume that diseases are usually the result of an imbalance between ‘protective’ and ‘harmful’ networks«, Mayer continues, describing the new approach of researchers. Even chronic diseases should be seen as a kind of ‘balance’ between protection and damage, which should also be taken into account in treating them.

In order to test such hypotheses researchers need to order the huge amounts of data obtained from analyses of genes and proteins to find out which of them are significant. To do this requires not only complex methods from bioinformatics and systems biology. »Ultimately it will be necessary«, says Gert Mayer, »to test the findings provided by these new technologies in conventional systems«.

Proteomics

SysKid research teams have already done this in one field, as Professor Harald Mischak from the Biotech company mosaiques diagnostics in Hannover reports at the Munich congress. Together with scientists in Denmark and Australia, Mischak’s team analysed patterns of particular protein substances, so-called biomarkers, in urine samples from diabetes patients, which doctors had collected in long-term studies over many years and frozen for research purposes. The scientists were able to show that changes in protein patterns in urine allow kidney disease to be detected at a very early stage, long before conventional tests would provide any indication of the disease. »If the disease is treated in this early phase progress could be prevented or even aboided«, Mischak says.

Systems biology

»We are optimistic, that the ‘omics revolution’ will provide us with sets of data that will enable us to analyse even complex diseases«, says Dr. Bernd Mayer, managing partner of the R&D company emergentec biodevelopment GmbH, Vienna, whose team is coordinating SysKid. But Mayer is equally convinced that the researchers still have to do their homework if they are to use bioinformatics to optimise the management and integration of already existing and new data: »Method development therefore has an important role to play in SysKid«. Nevertheless, systems biology, which seeks to use new insights into networked and dynamic life processes to piece together a complex puzzle, is still in its infancy. »I am optimistic, however”, says Mayer, making a bold prediction, »that systems biology will have a major influence on clinical research in the future and that the manifold possibilities offered by bioinformatics for analysis and integration of data will have a big role to play in this«.

The keywords are »omics« and »systems biology« in nephrology
»Only once we begin thinking in terms of networks and see the cell, the organ and the organism as a dynamic system that tries to maintain a stable balance (and it has many ways of doing so) will we make the advancements necessary to develop diagnostic, preventive and therapeutic strategies to combat chronic kidney disease.«

Prof. Dr. Gert Mayer, Department of Internal Medicine IV, Nephrology and Hypertension, Medical University of Innsbruck, Austria

Media Contact: Barbara Ritzert · ProScience Communications GmbH · Andechser Weg 17 · 82343 Pöcking · Fon: ++49 (08)157 9397-0 · Fax: +49 (0)8157 9397-97 · media@syskid.eu · www.syskid.eu

Barbara Ritzert | idw
Further information:
http://www.syskid.eu

More articles from Interdisciplinary Research:

nachricht X-shape Bio-inspired Structures
29.09.2016 | The Hong Kong Polytechnic University

nachricht Body Talk: A New Crowdshaping Technology Uses Words to Create Accurate 3D Body Models
27.07.2016 | Max-Planck-Institut für Intelligente Systeme

All articles from Interdisciplinary Research >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

 
Latest News

New Multiferroic Materials from Building Blocks

29.09.2016 | Materials Sciences

Silicon Fluorescent Material Developed Enabling Observations under a Bright “Biological Optical Window”

29.09.2016 | Materials Sciences

X-shape Bio-inspired Structures

29.09.2016 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>