cellular functions

Protein shredder regulates fat metabolism in the brain

Every cell in the body is surrounded by a fatty film called the plasma membrane. It also contains numerous proteins that span the membrane from outside to…

An Elegant Mechanism

The research labs of the associate professor Dr. Thomas Becker and Prof. Dr. Nikolaus Pfanner from the Institute for Biochemistry and Molecular Biology at the…

When the "guardian" and the "caretaker" of the genome join forces

Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance…

Molecular biologists discover an active role of membrane lipids in health and disease

The secretory capacity of a cell is controlled by a process known as the unfolded protein response (UPR). A central task of UPR is to detect misfolded…

Tracing down linear ubiquitination

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many…

How yeast cells regulate their fat balance

Not only humans but also each of their body cells must watch their fat balance. Fats perform highly specialised functions, especially in the cell membrane. A…

Chromosomes: the importance of keeping the balance

Before every cell division, the hereditary information, that is the chromosomes, are duplicated and distributed to the daughter cells so that each cell again…

Giant cell reveals its secrets

The “slime mold” Physarum polycephalum is an amazing creature. As a giant single cell it is visible with the naked eye. The yellow, slimy mass of protoplasm,…

A long-standing mystery in membrane traffic, the disassembly of a SNARE complex by NSF, was solved.

KAIST researchers discovered that the protein N-ethylmaleimide-sensitive factor (NSF) unravels a single SNARE complex using one round ATP turnover by tearing…

Transport molecule forms a protective structure to guide proteins to cell membrane

This structure shields tail-anchored membrane proteins – which have roles in a wide variety of cellular functions from neurotransmitter release to insulin…

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