Researchers discover two molecules that help fruitflies sleep.

Mutant flies that lack the chemicals sleep more. In mammals the same molecules are also involved in learning and memory, supporting the idea that one function of sleep is to consolidate our record of the day’s experiences 1 .

The molecules are cyclic AMP and CREB, chemical messengers that work within cells. Cyclic AMP activates CREB, which then switches on genes.

Joan Hendricks, of th

Two techniques may help deduce proteins’ functions.

Imagine trying to guess what machines do just be looking at them. Even a can-opener would pose problems, if you didn’t know about cans. This is the challenge that faces molecular biologists as they try to make sense of protein molecules in the cell.

Two new techniques may help. One deduces a protein’s function from its shape; the other deduces its shape from a list of component parts 1 , 2 .

Deforestation is drying out cloud forests.

“It drips,” says ecologist Robert Lawton, describing the Costa Rican cloud forest, “and it’s plastered with plants of all sizes climbing over each other. Stand still for long and they’re growing on you.”

Now the lush life he describes may be threatened. Satellite pictures show that deforestation at the foot of western Costa Rican mountains is drying out swirling summit mists.

When warm, wet tradewinds blowing off the Caribb

Meterologists look up for long-range forecasts.

Looking high into the atmosphere now might tell us whether we’re in for a white Christmas. Unusual stratospheric conditions herald changes in winter weather in the Northern Hemisphere up to two months later, say US researchers 1 .

The finding won’t let your weather forecaster warn you to wrap up warm two months hence, but it may be a valuable addition to meteorologists’ toolkits. “The effect works on average, bu

ATTO-TEC® has developed the second generation of fluorescent dyes which are stable at room temperature for more than six months.

With Atto 520, Atto 565 and Atto 590 we are pleased to offer three stable fluorescent dyes as amine-reactive succinimidyl esters which will be available from November 2001 on. This allows researchers an easy handling for selectively target- labeling by linking a fluorophore to primary amine groups on proteins or modified nucleic acids.
Further stable activate

Study questions whether mammography saves lives.

Breast-cancer screening programmes may not save lives, according to a new examination of clinical trials. The controversial findings have led to calls for a re-evaluation of the routine monitoring procedure undergone by numerous women.

Mammography, X-ray breast imaging, is used in Europe and the United States to catch cancers early. “We’ve based a national screening programme on a set of results which do not stand up to scrut

A large, long-term study confirms that diet can help some epileptic children.

A strict high-fat, low-carbohydrate, calorie-restricted diet reduces seizures in children with intractable epilepsy. So concludes the largest and longest trial of an eating plan that was first suggested almost a century ago.

For about two years, epileptic youngsters on a ’ketogenic diet’ eat 25% less than normal and consume 90% of their daily calories as fats. They take vitamins and minerals to avo

Chemists build molecules by paring them down

Complex molecules, such as many drugs, can be fiddly to assemble. By binding their starting compounds in chains 1 , chemists in Denmark may have found a way speed the automated chemical synthesis of such complicated products.

Les Miranda and Morten Meldal of Carlsberg University in Copenhagen have solved the following problem. Complex molecules are usually built up from a core with several near-identical hooks on w

About half of all patients with hereditary breast or ovarian cancer have mutations in a gene called BRCA1. Now the first images of the protein the gene encodes, BRCA1, are helping researchers work out how the mutations cause human disease.

The pictures reveal fine detail of how BRCA1 interacts with other proteins. Such information should help researchers work out how BRCA1 prevents cells becoming cancerous. They suspect that it is involved in DNA repair, controlling cell division and regula

European subsidies to enhance farmland wildlife may not be working.

The effectiveness of schemes that seek to promote biodiversity by paying farmers to cut back on intensive agriculture could be called into question by some research findings from Holland.

The incentive programmes, which already cost the European Union 1.7 billion euros (US$1.5 billion) each year and are rapidly expanding in scope, are partly motivated by the desire of European governments to subsidize farmin