The effectiveness of many potentially powerful treatments including drug therapy, gene therapy and cancer chemotherapy is often reduced because it can be difficult to target the treatment exactly where it will be most effective. One of the problems is that it is frequently difficult for drugs, as well as DNA and other biological molecules, to pass through the membranes of the targeted cells. Electroporation (EP), which involves the application of electrical pulses directly to the tissue to be treated

Using the equations of quantum mechanics, which normally govern the bizarre physics that occurs at tiny atomic scales, has enabled geophysicists to answer a much larger-scale question – what the Earth`s core is made from. At the Condensed Matter physics conference on Tuesday 9 April, part of the Institute of Physics Congress in Brighton, Prof Mike Gillan and Dr Dario Alfe from University College London will describe how their research has revealed not only the likely composition of the Earth`s core,

New research on steroid hormone action in the human colon and kidney could pave the way for novel therapeutic targets for the treatment of hypertension and diarrhoea.

Prof Brian Harvey at University College Cork has been studying how the hormones oestrogen and aldosterone produce rapid changes in the transport of salt and water through human intestines and kidneys. Human beings have two main organs that regulate the body’s salt and water balance (effectively blood pressure) – the kidney and

Scientists have discovered that plant leaves activate defence mechanisms against plant eating insects within twenty seconds of an insect walking across them. Dr Alan Bown will be presenting the results of his footsteps research at the Society for Experimental Biology conference on Tuesday 9 April.

Dr Bown and colleagues studied the effects of insects traipsing across leaves, observing the chemical responses in the leaves over time. Ten seconds after larvae had crawled across the leaves, supe

Ticks spread a greater variety of diseases than any other blood-feeding creature, including mosquitoes. Now scientists are developing vaccines that prevent ticks from digesting the blood of their animal or human victim, according to research presented today (Monday 08 April 2002) at the spring meeting of the Society for General Microbiology at the University of Warwick.

“A new solution to controlling tick-borne diseases is to develop vaccines against the ticks and not the microbes that cause

Protein packaging may enhance MRI contrast.

Images of body tissues and organs could soon be brighter and sharper thanks to a technique developed by Italian chemists. They have made the chemical contrast agents used in magnetic resonance imaging (MRI) produce a stronger signal by trapping them in protein cages just 12 millionths of a millimetre (nanometres) or so widesup> 1 .

Such improvements increase the contrast of the images, so they should reveal more detailed