The invention belongs to the field of generative/additive manufacturing (better known as „3D printing”). Additive manufacturing describes usually building up a structure layer by layer from a granulate or liquid using physical/chemical processes as melting or curing of a material.
In order to increase the storage stability and shelf life of milk, a new treatment process has been developed at Hohenheim University, one that also requires comparatively low treatment temperatures.
The milk can be kept at room temperature for up to a year and yet impresses with its good sensory properties and low vitamin loss.
Our novel concept of a pressure measurement using an ionisation manometer with decoupled electron source is based on the idea to maintain the classical, well-established geometry of hot cathode ionisation manometers for UHV/XHV, but to remove the heat-generating filament and to relocate the electron generation for the gauge into the room-temperature environment, where heat generation does not disturb.
This innovative solution was mainly developed for UHV/XHV pressure measurements under cryogenic conditions. However, it may be easily applied in any vacuum installations which are operated e.g. under high or medium vacuum and higher temperatures.
DNA lesions occur in all living organisms. As accumulating DNA damage poses a risk for cell survival, cells harbour sophisticated mechanisms for repairing such lesions. The kinase ATR (“ATM and Rad3 related”) is a key player in triggering the cellular response to double strand DNA breaks called “DNA Damage Response” (“DDR”) thereby enabling DNA repair and thus promoting cell survical.
As cancer cells are often characterized by defects in various DNA repair processes and/or DNA damages, intact ATR-signalling (and subsequent DNA-repair processes) is particularly crucial for the viability of such cancer cells.
In fact, blocking DDR, preferably by inhibiting ATR has become an attractive therapeutic concept.
Correspondingly, at present, two ATR inhibitors (VX-970 and AZD5738; for ref. see “Relevant Publications”) have already entered clinical studies.
However, both with the developmental risk associated with these compounds, the need for compounds displaying an improved safety-/efficacy-profile and the large number of patients, there is a huge interest in advanced ATR inhibitors.
The present invention thus relates to advanced ATR antagonists which have proven to be effective in various in cellular assays (both on its own and in combination with cisplatin). Furthermore they show a promising ADME-profile as deducted from predictive ADME modelling and an improved solulibility in relation to the aforementioned compounds.
Selective Enhancement of Ligands by Exponential Enrichment (SELEX) has proven to be a powerful tool for idenfying functional oligonucleotides which bind to selected targets. Here, in an iterative process, a pool of single stranded oligonucleotides is contacted with a target structure (e.g. a protein), high-affinity oligonucleotides are then isolated, amplified and again put into contact with the target until, eventually, an ideal oligonucleotide has been obtained.
An International and a European patent application are pending. On behalf of University of Bonn, PROvendis offers licenses for commercial use as well a research collaboration with licensing option.
By cascading two DOEs are optical elements (lens, axicon, phase shifter, spiral phase plate) obtained, whose optical power can be adjusted continuously by just rotating one DOE with respect to the other.
A novel mesh generation method enables a fast, fully automatic generation of high-quality meshes even for complex geometrical structures.
The invention presented here consists in the fact that via pow-der/air/water jet devices, induced through the special geometry of the instrument approach the cleaning powder/water jet is released in such a way that even the undercuts of the implant?s surface are cleaned effectively.
The technology enables the fast and competitive production of specific ALA via biotechnological process technology. The production of aminolevulinic acid (ALA) is the first step in the biosynthesis of tetrapyrroles and porphyrines (like Chlorophyll, vitamin B12, heme). Recently ALA has attracted interest as a selective and biodegradable herbicide and insecticide. Besides ALA can be applied in the photodynamic therapy and treatment of various kinds of cancer.
Administration of ALA in the tumorous tissue leads to a porphyrin formation inside the cells. Accumulated porphyrins generate reactive oxygene species when excited by light which can lead to death of the tumorous cell. On behalf of the University of Bielefeld, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.
By decoupling cell growth and productivity of biosynthesis the new method and associated Escherichia coli strain allow for an increase in productivity by a factor two to three.
This could not only be interesting for pharma industry, e.g. by increasing the capacity of insulation production, but for biotechnological synthesis of succinic acid as well. The demand for succinic acid as a component of plastics such as polyamides or polyesters is estimated to amount to 250,000 tons per year.
A new and cost saving method makes it possible to combine different components of any form. Manyfold material combinations such as carbon fiber composites and metals can be combined easily. With the material friendly technique high quality welding seams can be manufacured in a flexible manner without affecting the components global-thermally.
Scientists at the University Göttingen developed a monoclonal antibody against a biotinylable peptid (Epitope-Tag) called AP-tag or Avi Tag. This small peptide served as a substrate mimic for biotin ligase (BirA). Anti-AP antibodies are useful tools in the analysis of AP-tag fusion proteins.
A novel Fourier Transform Infrared (FTIR) spectroscopy based approach for rapid and reliable differentiation of fresh from frozen/thawed meat or fish. This fast and inexpensive high throughput technique represents a powerful tool to ascertain correct labeling of meat and fish.
Gerät zur Messung von mechanischen Eigenschaften von Böden und Oberflächen, dass ohne Führungselemente auskommt, keine Sensoren für Weg oder Geschwindigkeit benötigt und Energierückgewinnung, Federkonstante, Kraftreduktion und Resonanzfrequenz misst.
Inventors of Saarland University achieved to develop new neutral bis azainositol heavy metal complexes suitable for the use as X-ray contrast agents with a wide range of advantages compared to common contrast agents. For their higher absorption coefficient in the range of voltages used in CT these complexes lead to scan protocols that provide equivalent or even improved diagnostic value at lower radiation doses compared to conventional triiodinated contrast agents.
Sensitive sensors and other electronic and optoelectronic components require reliable capsulations, which withstand long-lasting environmental difficulty. Such housings, with grommets for electrical connections in surroundings with low air or rather gas pressure and in the vacuum technology, require particularly high standards.
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