When a neuron in our body gets damaged, segments of RNA produce proteins that can help repair the injury. But in neurological disorders such as ALS and spinal muscular atrophy, or following spinal cord injuries, the mechanisms for moving life-essential RNA to injured sites within the cell fail. As a result, RNA molecules can’t get to where they are needed and damage becomes permanent. Researchers at Stanford have developed a technology for transporting RNA to specific locations within a neuron,…
Researchers at University of Colorado Anschutz Medical Campus lead study that identifies gene mutations and cell maturity as key factors in acute myeloid leukemia drug resistance An international study led by the University of Colorado Cancer Center has uncovered why a widely used treatment for acute myeloid leukemia (AML) doesn’t work for everyone. The findings could help doctors better match patients with the therapies most likely to work for them. The study was published today in Blood Cancer Discovery. Researchers…
Portable tech captures molecules in breath to aid medical care from diabetes to newborn development If you’ve ever sat waiting at the doctor’s office to give a blood sample, you might have wished there was a way to find the same information without needles. But for all the medical breakthroughs of the 20th century, the best way to detect molecules has remained through liquids, such as blood. New research from the University of Chicago, however, could someday put a pause…
Researchers at the Francis Crick Institute have shown that gonadotrophs, cells in the pituitary gland with a key role in puberty and reproduction, come from two different populations, with the majority produced after birth rather than in the embryo, as previously thought. A better understanding of when these important cells develop could help researchers and clinicians understand and treat disorders that impact puberty and fertility. In the pituitary, a small gland located in the middle of the head and connected…
Researchers identify a decline in NAD levels as a key driver of T cell dysfunction and offer a potential rejuvenation strategy to improve immunotherapy outcomes in older cancer patients As people age, their immune systems become less efficient, posing a challenge for cancer therapies that rely on harnessing immune cells. In a new study published in Nature Cancer, researchers from the University of Lausanne (UNIL), the Lausanne University Hospital (CHUV), the Geneva University Hospitals (HUG) and the Ecole Polytechnique Fédérale…
Researchers have discovered how an ion channel in the brain’s neurons has a kind of ‘molecular memory’, which contributes to the formation and preservation of lifelong memories. The researchers have identified a specific part of the ion channel at which new drugs for certain genetic diseases could be targeted. The study, led from Linköping University in Sweden, has been published in Nature Communications. One of the brain’s superpowers is its ability to learn from past experiences and form memories. These…
Researchers at VIB-KU Leuven shed light on an unusual signaling pathway that orchestrates synaptic structure and function during brain development. Leuven, 20 May 2025 – Researchers from the lab led by Prof. Joris De Wit (VIB-KU Leuven) have discovered an important clue to how connections between brain cells, known as synapses, mature. These new findings, published in Developmental Cell, demonstrated how two different proteins, GPR158 and PLCXD2, interact to form a specific component in developing synapses – the spine apparatus….
A new paper in Nicotine and Tobacco Research, published by Oxford University Press, finds that today’s pod-style electronic cigarette devices are more addictive than nicotine gum, indicating that such devices have a very high potential for abuse. Since entering the market in 2003, electronic cigarettes have become very popular in the United States, particularly among youth and young adults. A significant proportion of people who use electronic cigarettes devices never used other tobacco products regularly. Over 30% of adult users…
Family of parasite proteins presents new potential malaria treatment target Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans. Targeting these proteins may hold promise for identifying new drugs that are less susceptible to resistance. Malaria infects over 200 million and kills over 500,000 people every year. It is caused by Plasmodium parasites…
Research finds a possible solution to a common problem during cold storage transportation Researchers have discovered a new molecular process that occurs when donor hearts are preserved in cold storage which contributes to failure after transplant, a study in both humans and animals shows. The team, a collaboration between Michigan Medicine and Mayo Clinic, also found a therapy to reduce that damage using medication that is typically prescribed for high blood pressure. Investigators say the therapeutic solution can significantly improve…
Belgrade, Serbia – 17 May 2025. An artificial intelligence-enabled electrocardiogram-based algorithm performed well in the early detection of heart failure among healthcare-seeking individuals in Kenya, according to late-breaking research presented today at Heart Failure 2025,1 a scientific congress of the European Society of Cardiology (ESC). Heart failure is highly prevalent in Sub-Saharan Africa, where patients are often younger and face worse outcomes than in high-income countries.2 Explaining the rationale for the current study, presenter Dr. Ambarish Pandey from the University…
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, most often caused by cigarette smoking or long-term exposure to air pollutants. While there is no cure, progression can be slowed by reducing exposure to these factors. A new study from Mass General Brigham researchers uncovered another factor linked to progression of the disease: the accumulation of mucus in the lungs. People with COPD who had persistent airway-clogging mucus plugs over a five-year period…
In well-designed gardens, our gaze shifts quicker and more often. Researchers believe this could be key to understanding the relaxing effects gardens can have on viewers. When was the last time you sat in a garden and simply let your gaze wander? Observation gardens are built especially for this purpose, but can also fulfil other functions, such as providing aid for meditation. Now, an international team of researchers has investigated what it is about these gardens that makes us feel…
Could a mini-stroke leave lasting fatigue? MINNEAPOLIS — A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year. The study is published on May 14, 2025, online in Neurology®, the medical journal of the American Academy…
Updated estimates point to need for more treatment A large percentage of American children are growing up in households with at least one parent who uses alcohol or other drugs in problematic ways—raising the risk that those children will go on to do the same, a new study suggests. Using data from 2023 to give as current a view as possible, the researchers estimate that 19 million children—1 in 4 of Americans under age 18—live with a parent or other…
Like GLP-1, hormone works by signaling the brain OKLAHOMA CITY – A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function. University of Oklahoma researcher Matthew Potthoff, Ph.D., is the lead author of the study, which provides valuable insight about the mechanism of action of the hormone, which is a…
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