Family of parasite proteins presents new potential malaria treatment target Researchers from the Francis Crick Institute and the Gulbenkian Institute for Molecular Medicine (GIMM) have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans. Targeting these proteins may hold promise for identifying new drugs that are less susceptible to resistance. Malaria infects over 200 million and kills over 500,000 people every year. It is caused by Plasmodium parasites…
Research finds a possible solution to a common problem during cold storage transportation Researchers have discovered a new molecular process that occurs when donor hearts are preserved in cold storage which contributes to failure after transplant, a study in both humans and animals shows. The team, a collaboration between Michigan Medicine and Mayo Clinic, also found a therapy to reduce that damage using medication that is typically prescribed for high blood pressure. Investigators say the therapeutic solution can significantly improve…
Belgrade, Serbia – 17 May 2025. An artificial intelligence-enabled electrocardiogram-based algorithm performed well in the early detection of heart failure among healthcare-seeking individuals in Kenya, according to late-breaking research presented today at Heart Failure 2025,1 a scientific congress of the European Society of Cardiology (ESC). Heart failure is highly prevalent in Sub-Saharan Africa, where patients are often younger and face worse outcomes than in high-income countries.2 Explaining the rationale for the current study, presenter Dr. Ambarish Pandey from the University…
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, most often caused by cigarette smoking or long-term exposure to air pollutants. While there is no cure, progression can be slowed by reducing exposure to these factors. A new study from Mass General Brigham researchers uncovered another factor linked to progression of the disease: the accumulation of mucus in the lungs. People with COPD who had persistent airway-clogging mucus plugs over a five-year period…
In well-designed gardens, our gaze shifts quicker and more often. Researchers believe this could be key to understanding the relaxing effects gardens can have on viewers. When was the last time you sat in a garden and simply let your gaze wander? Observation gardens are built especially for this purpose, but can also fulfil other functions, such as providing aid for meditation. Now, an international team of researchers has investigated what it is about these gardens that makes us feel…
Could a mini-stroke leave lasting fatigue? MINNEAPOLIS — A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year. The study is published on May 14, 2025, online in Neurology®, the medical journal of the American Academy…
Updated estimates point to need for more treatment A large percentage of American children are growing up in households with at least one parent who uses alcohol or other drugs in problematic ways—raising the risk that those children will go on to do the same, a new study suggests. Using data from 2023 to give as current a view as possible, the researchers estimate that 19 million children—1 in 4 of Americans under age 18—live with a parent or other…
Like GLP-1, hormone works by signaling the brain OKLAHOMA CITY – A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function. University of Oklahoma researcher Matthew Potthoff, Ph.D., is the lead author of the study, which provides valuable insight about the mechanism of action of the hormone, which is a…
Scientists observed chimpanzees in Uganda apparently cleaning and treating their own and others’ wounds Scientists studying chimpanzees in Budongo Forest, Uganda, have observed that these primates don’t just treat their own injuries, but care for others, too — information which could shed light on how our ancestors first began treating wounds and using medicines. Although chimpanzees elsewhere have been observed helping other community members with medical problems, the persistent presence of this behavior in Budongo could suggest that medical care…
Research from the University of Adelaide shows microbial communities in echidna pseudo-pouches undergo dramatic changes while the animal is lactating, which could help in creating an environment for their young, known as puggles, to thrive. Echidnas are monotremes, which are the only mammals that lay eggs. The early developmental stage at which they hatch from their egg means that the puggles lack a functioning immune system. “We know the reproductive microbiome is important to infant health, including for humans, but…
FIT would still be more cost-effective even if Cologuard and Cologuard Plus test costs were lowered to $100 Embargoed for release until 5:00 p.m. ET on Monday 12 May 2025 Follow @Annalsofim on X, Facebook, Instagram, threads, and Linkedin Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict…
Researchers at Amsterdam UMC followed 1955 young transmasculine and gender-diverse individuals, who used testosterone for an average of five years, finding no increased risk Transmasculine and gender-diverse individuals who use testosterone are not at increased risk of gynecological cancer in the first years of hormone therapy. This is evident from large-scale research by Amsterdam UMC, which was published today in eClinicalMedicine. The results provide important insights for healthcare providers and transmasculine and gender-diverse individuals who are considering starting hormone therapy….
CAR-T cells cause brain fog After treatment with CAR-T cells — immune cells engineered to attack cancer — patients sometimes tell their doctors they feel like they have “brain fog,” or forgetfulness and difficulty concentrating. A new Stanford Medicine-led study shows that CAR-T cell therapy causes mild cognitive impairments, independent of other cancer treatments, and that this happens via the same cellular mechanism as cognitive impairment from two other causes: chemotherapy and respiratory infections such as flu and COVID-19. The…
Researchers from the Keck School of Medicine of USC found that obesity, gestational diabetes and hypertensive disorders of pregnancy were tied to elevated blood pressure in offspring, with effects that grow as children age. Children born to mothers with obesity, gestational diabetes mellitus or a hypertensive disorder of pregnancy have higher systolic and diastolic blood pressure than children born to mothers without these risk factors, according to a new USC study. Among children whose mothers had at least one risk…
A team of researchers from the Department of Diagnostic and Therapeutic Ultrasonography at the Tianjin Medical University Cancer Institute & Hospital, have published a review (DOI: 10.20892/j.issn.2095-3941.2024.0376) in Cancer Biology & Medicine. The paper underscores the potential of AI to decode complex biological data with unprecedented speed and accuracy. By integrating genomics, medical imaging, and pathology at scale, AI is paving the way for data-driven strategies that bring precision medicine from theory into real-world clinical practice. In the realm of…
In an effort to curb misuse of opioids and prevent overdose deaths, the College of Physicians and Surgeons of British Columbia released a legally enforceable practice standard, Safe Prescribing of Drugs with Potential for Misuse/Diversion, in 2016. This document limited prescribing of opioids for chronic noncancer pain (CNCP) with specific prescribing practices that clinicians were obligated to follow. In research that tested the effects of the 2016 practice standard on prescribing to patients with CNCP, researchers found that its introduction had…
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