In the fight against malaria, controlling the mosquito population is crucial. Several methods are currently used to reduce mosquito numbers and malaria risk. One of these includes the antiparasitic medication ivermectin. When mosquitoes ingest blood containing ivermectin, it shortens the insect’s lifespan and helps decrease the spread of malaria. However, ivermectin has its own issues. Not only is it environmentally toxic, but also, when it is overused to treat people and animals with worm and parasite infections, resistance to ivermectin…
A study published in The American Journal of Pathology demonstrates that Piezo2 is a critical mechanoreceptor involved in stiffness-mediated profibrotic fibroblast phenotypes Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical forces in tissues including stress, strain, and stiffness. The new study in The American Journal of Pathology, published by Elsevier, sheds light on the underlying mechanisms of…
Joseph Wilson, Anthony Hunsaker publish findings about Utah’s Pollinators in the journal ‘Diversity’ Wildlife conservation is critical to sustaining the planet’s biodiversity and health. But putting together a conservation plan is a tall order. First of all, you need to determine what species you’re conserving, along with their numbers, habitat needs, threats and how they fit into a complex ecosystem. As pollinators for native plants and food crops, bees play a pivotal role in our ecosystem, according to Utah State…
Research opens door to developing therapies for neurodegenerative diseases As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be contributing to neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, among others. Now, researchers at Washington University School of Medicine in St. Louis report they have found a way around that problem by targeting the network of vessels that drain waste from the brain. Rejuvenating those vessels, they have…
The research may enable the design of synthetic, light-activated cells for wound healing or drug delivery. Life takes shape with the motion of a single cell. In response to signals from certain proteins and enzymes, a cell can start to move and shake, leading to contractions that cause it to squeeze, pinch, and eventually divide. As daughter cells follow suit down the generational line, they grow, differentiate, and ultimately arrange themselves into a fully formed organism. Now MIT scientists have…
A new technique has enabled ultra-powerful magnetic resonance imaging (MRI) scanners to identify tiny differences in patients’ brains that cause treatment-resistant epilepsy. In the first study to use this approach, it has allowed doctors at Addenbrooke’s Hospital, Cambridge, to offer the patients surgery to cure their condition. Previously, 7T MRI scanners – so called because they operate using a 7 Tesla magnetic field, more than double the strength of previous 3T scanners – have suffered from signal blackspots in crucial…
Scientists at St. Jude Children’s Research Hospital found that removing one protein from tumors could help thwart cancer cells in multiple ways, enhancing immunotherapy effects Targeted inhibition of a “signal jammer” protein may improve how tumors respond to immunotherapy. Published today in Nature, a new study demonstrates how some cancer cells use the protein voltage-dependent anion channel 2 (VDAC2) like a signal jammer to prevent the body’s anticancer systems from communicating with the immune system. The research also reveals the…
Newly described protein drives immune response, offers potential target for treatment Autoimmune diseases, which are estimated to affect more than 15 million people in the U.S., occur when the body responds to immune-system false alarms, and infection-fighting first responders are sent out to attack threats that aren’t there. Scientists have long understood how the false alarms get triggered, but the second step of dispatching the immune response has been a mystery. Now, scientists at Washington University School of Medicine in…
In experiments conducted at the University of São Paulo, tumor stem cells became less able to proliferate and invade tissues when the production of the prion protein was blocked by gene editing; the results suggest that the molecule could be a therapeuti Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In Brazil, although no exact…
Researchers led by CHLA’s Jonathan D. Santoro, MD, have identified signs of neuroinflammation and dysfunction of the blood-brain barrier among patients with Down syndrome Regression Disorder (DSRD). A new research study led by Jonathan D. Santoro, MD, Director of the Neuroimmunology Program at Children’s Hospital Los Angeles, shows evidence of dysfunction of the blood-brain barrier and inflammation in the central nervous system in individuals with Down syndrome Regression Disorder (DSRD). The new study, “Evidence of blood–brain barrier dysfunction and CSF…
Data reveals that retention bans are a good first step, but won’t be enough to prevent continued decline Despite the fear they may inspire in humans, sharks have far more reason to fear us. Nearly one-third of sharks are threatened with extinction globally, mostly as a result of fishing. A team led by researchers at UC Santa Barbara discovered that mandates to release captured sharks won’t be enough to prevent the continued decline of these important ocean predators. These findings,…
Study reveals new information about how to prevent chronic inflammation from zombie-like cells that accumulate with age In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way. Certain factors can cause cells to abandon this characteristic and enter a zombie-like state known as senescence where they persist but no longer divide to make new cells. Our bodies can remove…
University of Arizona neuroscientists studying the brains of songbirds have found that aging alters the gene expressions that control the birds’ song. The finding could lead to earlier diagnoses and better treatments for human neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, which are known to hinder vocal production in their early stages. The study, published in the journal Neurobiology of Aging, found that networks of interacting genes, in a region of the bird’s brain involved with singing, dramatically…
A new type of antibody which stimulates the immune system to target cancer cells slows tumor growth, according to new research Antibody treatment which activates the patient’s own immune system against cancer, known as immunotherapy, is increasingly being investigated as an alternative for chemotherapy and radiotherapy. This is because it specifically targets the cancer cells, which reduces the side effects seen with more conventional therapies. Tumours, such as some breast and ovarian cancers, can express the marker HER2. HER2 is…
Study links genetics, vision and neural processing to mating behavior in Heliconius butterflies A simple neural change alters mating preferences in male butterflies, aiding rapid behavioral evolution, Nicholas VanKuren and Nathan Buerkle at the University of Chicago, US, and colleagues, report March 11th in the open-access journal PLOS Biology. Heliconius are a group of tropical butterflies known for their wide variety of wing patterns and colors, which act as a warning to predators. Because wing coloration is crucial for their…
Scripps Research scientists created a stable form of carnosic acid, observing greater memory function and other disease improvements in mice. The herb rosemary has long been linked with memory: “There’s rosemary, that’s for remembrance,” says Ophelia in Shakespeare’s Hamlet. So it is fitting that researchers would study a compound found in rosemary and sage—carnosic acid—for its impact on Alzheimer’s disease. In the disease, which is the leading cause of dementia and the sixth leading cause of death in the US,…
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