The present invention HerpHu-mAb provides a humanized anti-HSV antibody that is capable of neutralising HSV infections and inhibiting the cell-to-cell spread that is crucial during HSV reactivations.
HerpHu-mAb revealed as highly effective in prevention of ocular HSV infections as well as lethal infections under immune-suppressed conditions in the corresponding animal models. Moreover, HerpHu-mAb proved to be capable of overcoming drug resistant HSV infections. Since HerpHu-mAb specifically binds to a highly conserved surface antigen that is essential for the viral fitness, the development of drug resistance is most unlikely.
Due to the high infection rates of the population and due to the frequent reactivation of the lifelong persisting virus, HSV is of particular clinical relevance. A passive immunoprophylaxis is currently not available. A couple of experimental vaccines for active immunization against HSV1 and HSV2 showed no verifiable success.
HerpHu-mAb represents a new alternative for the treatment and prevention of HSV infections that is capable of overcoming drug resistances to conventional therapies.
Ionenstrahlen finden in vielen Gebieten wie Medizin, Halbleiterindustrie und auch in der Grundlagenforschung Anwendung. Hierbei werden hohe Anforderungen an die Qualität des Ionenstrahls gestellt, so dass die Bestimmung der Energie des Ionenstrahls, d.h. seine Kalibrierung, essentiell ist.
Die vorliegende Innovation beschreibt ein Messgerät und ein Verfahren um die Energie beschleunigter Ionen zu bestimmen ohne diese zu stören.
Scientists at the University of Hohenheim, Germany, have developed the first biological and bee-friendly Varroose control method. The method exploits the fact, that female mites exude a pheromone which incites the mating behavior of the males.
After isolating the pheromone and identifying its components, followed another breakthrough with the discovery, that single components of the pheromone affect the mating behavior effectively, too. Currently the scientists run successful field tests using oleic acid, a low-priced component, which is unproblematic with regard to food regulations and suitable for application as a spray.
The hierarchical and precisely controlled process creating ribosomes in living cells is known as ribosome assembly and is relatively little researched. In the eyes of many experts the early processes in the creation of ribosomes offer attractive targets for antimicrobial agents. The systematic search for such substances is made more difficult by the fact, that currently no suitable screening processes exist.
The present invention consists of stable bacterial strains with ribosomal subunits incorporating fluorescent markers, which have growth characteristics similar to wild type, and which have an intact translation apparatus. The positioning of the fluorophores allows for disturbances in the ribosome assembly to be detected in vivo by a fluorescence-based readout process. The process has been optimized for use with multi-well plates and thus is suitable for use in high throughput screenings (HTS).
In vitro transcription/translation systems (ivtt) are used in biotechnology mainly to produce recombinant proteins whose production in vivo would be toxic. The experimental analysis normally involves autoradiography, i.e. it requires the labelling of translation products with radioactive isotopes. Handling these isotopes is expensive, a potential health hazard and limits throughput.
The present invention consists of stable bacterial strains with ribosomal subunits incorporating fluorescent markers, which have growth characteristics similar to wild type and which have an intact translation apparatus. This opens the opportunity for measuring the translation activity in real time using fluorescence. It is possible to carry out experiments in a shorter time and at less cost in multi-well plates, varying several reaction parameters in parallel to optimize yield.
Ein feldgeführter planarer Präzisionsmotor mit luftgelagertem Läufer ist
mit verkürzten planaren Antriebsspulen ausgestattet, die zwecks
energieminimierter Erweiterung des Verfahrbereiches in ihren X- und Y-
Koordinaten jeweils präzisionslineargeführt und bewegt werden und der
Bewegung des Hauptläufers synchron folgen.
Scientists from Stuttgart University developed a flexible high-density fibreboard with slip-resistant and shock-absorbent properties. The fibreboard consists of 80 % to 90 % straw, a natural, annually renewable fibre and agricultural by-product. It can be produced free of formaldehyde and isocycanate, making it the ideal solution for various indoor applications and minimizing the health risks during the product's entire life cycle. In addition to being recyclable and compostable the new fibreboard is highly flexible and therefore suitable for designing free-form furniture and interior spaces.
We present a novel network design for high-performance computing (HPC). Our network architecture provides a scalable, low-cost, and power-efficient network with very high bandwidth and low latency.
Researchers at the Karlsruhe Institute of Technology (KIT) have successfully developed low-cost, fluorescent dyes with especially high light intensities. These inorganic–organic hybrid dyes can be synthesized easily and isolated, stored and redispersed in common solvents (ethanol/water). They can be excited using blue light (UV or blue light from LED) and emit depending on their composition in the blue, green, red or infrared spectrum. Preferred are applications in the field of medical diagnostic and therapeutic, advertising material and safety equipment (fluorescent marker).
At present about 18 million people worldwide suffer from Alzheimer disease, a neurodegenerative disorder which leads to dementia. The pharmaceuticals currently registered for the treatment of Alzheimer are only able to reduce symptoms marginally and delay progression of Alzheimer disease to a limited extent. The novel preventive target structure, the APP-AICD/ Fe65-PTB2 complex, offers a new chance for the development of a possible pharmaceutical for a causal treatment of Alzheimer disease.
The invention concerns a surgical drape, especially for surgical interventions on the brain or head.
These novel drapes are provided to cover two areas. First the sterile cover of the area of surgery and additionally the sterile cover for a surveying system, especially with infrared radiation.
Previous drapes, especially for surgeries on the brain or head have only one fenestration in the area under the contact area of the patients head.
The tin-enriched adhesive system according to the invention provides a better and more durable bonding of tooth-colored filling materials (composites/ceramics) to eroded hard tooth substance. This system was specifically designed for individuals with pre-eroded teeth, can however also be used for all other indications of tooth-colored restorations.
This invention offers a new method for the direct and halogen-free formamide or acetamide formation of adamantane.
The adamantane modifications are chosen to enhance lipophilicity and stability of drugs, thereby improving their pharmacokinetics. Amido- and amino admantane derivatives can be used as drug delivery systems. They are able to overcome the blood-brain barrier and are competent to penetrate into the fatty tissue.
Due to these properties adamantane derivates are already used as therapeutics (e.g. for neurodegenerative diseases) and cosmetics. They are, for example, used as antiviral drugs or to treat Parkinson?s as well as Alzheimer?s diseases.
MRIs are used predominantly in lung diagnostics. The innovation can be used as contrast agent. 3He is harmless when used as contrast agent and is already used in research for this purpose. Though modern MRIs can generate images from all body areas without any contrast agent, the use of 3He, in particular in examinations of the lungs, significantly increases the contrast and therefore the resolution, enabling cancer tumors or infections to be detected more efficiently.
Furthermore, the 3He magnetometer can be used in all forms of therapy that work using magnetic fields, such as thermotherapy with magnetic nanoparticles (nano-cancer therapy) that selectively impair tumor cells through heat. The magnetic fields used have to be adjusted individually before each therapy session.
In the analysis of biological samples, specimens are often investigated with methods in sequential order. In order to make this possible, the adequate preservation of samples is an essential prerequisite. A commonly used procedure is in this case the cooling of samples to -20° C to -80° C by freezing.
Disadvantageous is however so far that, due to insufficient thermal insulation sample temperatures gradually approximate the ambient temperature within the respective device. The sample to be investigated consequently thaws, which negatively influences the quality of downstream investigation procedures or even causes a destruction of the structural integrity of the specimen.
The invention solves this problem by the use of a hollow cylinder which consists of thermally insulating, X-ray translucent material as insulating body.
For the medical treatment of lung diseases pharmaceuticals are often applied by inhalation. The release of the active agent occurs within a very short time-period. If the release of the active agent is to be delayed in order to achieve a most uniform release during a longer period of time, aqueous dispersions of encapsulated active substances are used.
The basic idea of the innovation is the application of polymer solutions containing active substances and forming particles only after nebulisation at the intended site of deposition.
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