The peptides identified by our inventors block the intracellular activity of the HPV16 E6 protein and thus increase sensitivity of tumor cells towards apoptosis. This effect is highly specific for HPV16-containing tumor cells.
Method for the enrichment of diagnostic target molecules based on CD24 positive exosome purification, enabling the development of mainly cancer or fetal diagnostics and reducing false negative test results due to diluted diagnostic target molecules.
L1 is overexpressed in highly malignant carcinomas and human ovarian tumors. The antibody 9.3 has improved anti-tumor capacities by inhibit tumor growth and invasion of tumor cells. Antibody can be also used to determine the L1 level in a patient.
Quadscanner for High Resolution Scanning Microscopes and Array Readers. The key facts are: (1) Fast, adaptive optical scanning device; (2) Completely free positioning of the scanning mirrors regarding the conjugated back focal plane; (3) Calibration with 4 galvanometers; (4) Application in high resolution microscopes (fluorescence, Raman, STED, localization), but also in Array Readers.
The technology specifies a novel device which allows to stabilize images of optical microscopes with high resolutions against externally induced oscillations and drift effects. In particular for optical microscopes, which achieve a higher resolution, it is important to ensure a high mechanical stability of the structure of microscope for a good image quality. It improves the performance of instruments such as laser scanners, fluorescence microscopes, Raman systems, STED- or localization-microscopes.
The site-directed modification of e.g. biomolecules is often time consuming and laborious. This invention provides a high yielding and highly specific method to link nearly any molecule to nearly any other molecule. The “Click reaction” used is the well known Diels-Alder reaction with inverse electron demand. In this fast reaction an appropriate, easily functionalized dien (e.g. Tetrazin) is reacted with an appropriate functionalized dienophil (e.g. Olefin) to yield the conjugate. The release of nitrogen makes the reaction irreversible. No side reactions occur. Further the Intellectual Property covers specific information regarding the ligation of a diagnostic marker AND a therapeutic agent AND a biomolecule. Convincing synthetic data are available for the ligation of peptide with peptide, peptide with marker molecule, peptide with therapeutic agent, peptide with oligo nucleotide, dendritic structure and specific surface modification by means of this technology.
Optical fluorescence and gamma-labeled radio-pharmaceutical imaging offer complementary ways of probing and assessing the physiology of small animals. With the increasing use of both methods for functional molecular imaging in small animal models for applications such as cancer research and drug development, it has become more important to integrate their results, particularly for studies of the same animal. This can be performed through image registration of separate studies or through simultaneous tomographic acquisition with implicit registration of the two imaging modalities. DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for single-photon emission computed tomography (SPECT).
New method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific applications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be selected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant do-mains of human immunoglobulins with the respective gene.
The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.
OPoLiCom is a system that continuously monitors the access impedance over frequency. If the access impedance spectral density below a threshold value, in the respective frequency range, no power is fed. Since the maximum power consumption of a PLC transmitter is limited, it ensures that in the frequency ranges with sufficiently high access impedance sufficient power can be fed. This is necessary for a good signal-to-noise ratio. By using OFDM with strong channel coding as in the just now standardized method, the absence of a portion of transmission frequencies can be compensated without any information to the receiver. This allows a standard-compliant implementation.
The invention at hand provides novel inhibitors for human proprotein convertase, which have antibacterial and antiviral effects. These inhibitors are multibasic, N-terminally modified tetrapeptide derivatives having a C-terminal P1-arginine mimetic. In contrast to previous active substances against bacterial and viral diseases, the substances presented here do not apply to the pathogenic organism, but the host, so that there is no development of resistance to contend with.
The invention describes a method for the in-situ conversion of chemically fixed carbon dioxide into low-molecular weight organic compounds by direct heterogeneous catalytic or electrochemical hydrogenation.
Scientist at the University of Stuttgart, Germany, have developed a new microtip measuring catheter that is equipped with a triaxial acceleration sensor and several pressure sensors around its circumference. The novel urodynamic catheter has been specifically developed for the diagnosis of urinary incontinence. Its considerable improvement in diagnosis allows for an optimized treatment of incontinence. A prototype of the catheter is currently subject to animal testing.
he novel radiolabeled exendin derivatives provide a highly specific diagnostic tool for the detection of beta cells in the pancreas of patients at risk of developing diabetes or already having diabetes. An imaging protocol has been developed that allows single time point quantitative SPECT/CT imaging to allow for simple, time-efficient clinical imaging.
The product is ready-to-use for clinical applications and gives for the first time the opportunity for detection of changes in beta cell mass in persons with diabetes or at risk to develop the disease. The possibility of beta cell mass quantification is fur-thermore associated to the chance of validation of therapy success with already available medicaments or new drug candidates that may preserve or increase beta cell mass.
Lasers as sources for coherent and intense light are used in many high-tech applications and medical devices. Generally, the generation of Laser-light is characterized by a significant level of optical and electrical energy input and low efficiency.
Contrary to the Laser, BEL utilizes an organic dye/polymer system, which is arranged between two mirrors forming an optical micro-cavity. The incoming light is multiply reflected between the mirrors, giving rise to an effective photon mass and a confining potential – key prerequisites for the Bose-Einstein condensation of photons. Thermalisation is achieved by the photon scattering off the dye molecules, resulting in a strong light concentration effect into the centre of the confining potential, where the potential energy is minimized. The spatial concentration is a consequence of the thermalisation of the trapped photon gas.
Commercial Opportunity:
For many Laser applications, coherent but not necessarily monochromatic light is required. The strong light concentration effect of BEL and the generation of coherent light with high intensity offer opportunities for a range of applications. For these applications, BEL can be a efficient light source for coherent visible and UV light. In contrast to a Laser, where significant share of the energy is lost in heat, BEL allows the design of an efficient solid state “cold Laser”.
T-cells play key roles in many diseases: they defeat infections, attack “self” tissue in autoimmune diseases and they attack tumor tissues. T-cell antigens are in direct causal relation to pathogenesis.
Antigen determination of tissue–invasive lymphocytes: The invention is a method for the identification of T-cell epitopes of 7-10 amino acids in length (e.g. linear antigen sequence). No prior information about the nature of the antigen entity required. It is an HTS method with extremely high sensitivity (one positive cell detected in 10,000,000 negative cells within a few hours).
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