Based on the mechanisms adopted by birds, bats, insects and snakes, 14 distinguished research teams have developed solutions to some of the common problems…

Michael Lewis's bestselling book “Flash Boys” describes how some brokers, engaging in high frequency trading, exploit fast telecommunications to gain…

If confirmed by further observations, a halo of dark matter could mean that the Smith Cloud is actually a failed dwarf galaxy, an object that has all the right…

Researchers from CIC nanoGUNE, in collaboration with ICFO and Graphenea, introduce a platform technology based on optical antennas for trapping and controlling…

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system and various other organs. In patients, lipid storage causes a progressive loss of myelin leading to various neurological symptoms. The sulfatide storage in ASA-deficient mice is comparable to humans, but the mice do not mimic the myelin pathology.
Therefore, transgenic ASA-deficient (tg/ASA(-/-)) mice were generated overexpressing the sulfatide-synthesizing enzyme galactose-3-O-sulfotransferase.

Tool coils for or magneforming (or electromagnetic forming = EMF) of complex, 3D shaped parts were previously wound from wires or produced by complex
processes such as milling and wire eroding. The milling process is necessary to produce the outer contour. Wire eroding is used to create the winding structures,
whereby it should be noted, that a 3D design is very limited. The invention concerns to special coils
for EM forming and for a method for their production, wherein the current-carrying coil body is additively manufactured using a rapid prototyping method (laser
melting, etc.).

Web services companies, such as Facebook, Google and Microsoft, all make promises about how they will use personal information they gather. But ensuring that…

A team led by Lars Fuhrmann from MPIfR Bonn, performed intensive, multi-frequency radio observations with some of the best single-dish radio telescopes in…

Wolf-Rayet stars are notable for having strong stellar winds and being deficient in hydrogen when compared with other stars. Taken together, these two factors…

In addition to the general construction permit for the new particle accelerator facility FAIR, since 2011 the detailed construction plans for the individual…

Many of the oldest and most massive galaxies reside in clusters, enormous structures where numerous galaxies are found concentrated together. Galaxy clusters…

<b>Background</b>
Protein kinase C zeta (PKCζ) is implicated in the development of several inflammatory diseases and a promising therapeutic target. PKCζ controls TH2 response and is important for the regulation of NF-κB transcriptional activity. Moreover, there is increasing evidence for an involvement of PKCζ in tumor development, where it controls chemoresistance and cancer–related inflammation.

<b>Invention</b>
Scientists of Saarland University and German University in Cairo have discovered 1,3,5-trisubstituted and 1,3,4,5-tetrasubstituted pyrazolines as a potent and selective class of allosteric PKCζ inhibitors. Several of the compounds show inhibitory activity in the nanomolar range. The compounds have an allosteric mode of action by binding the less conserved PIF pocked domain and are highly selective for the specific PKC isoform.

<b>Applications</b>
The present technology opens up an innovative therapeutic approach for the treatment of inflammatory diseases in which the identified compounds can serve as starting points for drug development. First experiments indicate relevance particularly for chronic obstructive pulmonary disease (COPD).

<b>Advantages</b>
• Innovative potent small molecules for selective PKCζ inhibition
• Allosteric mode of action increases selectivity
• Highly versatile scaffold for the independent optimization of four substituents
• Specific targeting may contribute to fewer side effects
• Potential treatment of diseases with high unmet medical need

There are already a number of Intel Parallel Computing Centers existing and their mission is to facilitate software development of highly parallel programming…

A quantum particle can search for an item in an unsorted “database” by jumping from one item to another in superposition, and it does so faster than a…

For decades, theorists have speculated that in its very first moments, our universe underwent a mind-bogglingly fast expansion that took it from the diminutive…

Trey Mack, a graduate student in astronomy at Vanderbilt University, has developed a model that estimates the effect that such a diet has on a star’s chemical…