Young stars ejecting plasma could give us clues into the Sun’s past Kyoto, Japan — Down here on Earth we don’t usually notice, but the Sun is frequently ejecting huge masses of plasma into space. These are called coronal mass ejections (CMEs). They often occur together with sudden brightenings called flares, and sometimes extend far enough to disturb Earth’s magnetosphere, generating space weather phenomena including auroras or geomagnetic storms, and even damaging power grids on occasion. Scientists believe that when…
Computing experts at Sandia National Laboratories have launched an effort to help discover what computers of the future might look like, from next-generation…
The ABC4Trust research team is piloting this technology with young people, often thought to be the less careful about their online security. But 'that’s not…
“Magnetic fields are ubiquitous in the universe,” said Don Lamb, the Robert A. Millikan Distinguished Service Professor in Astronomy & Astrophysics at the…
University of Pittsburgh researchers have become the first to detect a fundamental particle of light-matter interaction in metals, the exciton. The team will…
One of the major challenges for using graphene in electronics applications is the absence of a band gap, which basically means that graphene's electrical…
Supernova explosions, triggered when the fuel within a star reignites or its core collapses, launch a detonation shock wave that sweeps through a few light…
This was the first CME observed by the Interface Region Imaging Spectrograph, or IRIS, which launched in June 2013 to peer into the lowest levels of the sun's…
Published in the journal Physical Review Letters, the researchers from the University's Institute for Photonics and Advanced Sensing (IPAS) report they have…
A Swedish-German research team has successfully tested a new method for the production of ultra-strong cellulose fibres at DESY's research light source PETRA…
The German Research Foundation (DFG) has approved the establishment of a new collaborative research center (CRC) to be coordinated by Johannes Gutenberg…
Here, relativistic electrons in a storage ring are employed to generate very brilliant and partly coherent light pulses from the THz to the X-ray regime in…
Two of the six instruments that will fly on NOAA's first Geostationary Operational Environmental Satellite – R (GOES-R) satellite have completed integration…
During this year's Atlantic hurricane season, NASA is redoubling its efforts to probe the inner workings of hurricanes and tropical storms with two unmanned…
The co-stimulatory CD40-CD40L dyad is crucial in the development and progression of immune responses and chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis. However, long-term antibody-mediated inhibition of CD40L or CD40 is not clinically feasible as it results in thromboembolic events and severe immune suppression. More downstream inhibition of the CD40L-CD40 pathway is therefore preferable, especially tumor necrosis factor receptor-associated factors (TRAFs) recruited by CD40. Here we created a set of inhibitors that selectively block CD40-TRAF6 interactions. The rest of the CD40 cascade is left unaffected preventing unwanted immune-suppressive side effects. Therefore, our new inhibitors offer promising candidates as therapeutic agents for the treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis.
Experiments at the University of Bonn have shown that the expression of MED15, a subunit of the trans-criptional co-regulator Mediator, correlates with the proliferative activity of cells. MED15 is essential for TGF-ß-signaling and control of cholesterol/lipid homeostasis. The protein shows low frequency in androgen-sensitive prostate cancer and lacks expression in benign prostatic tissue.
Transmission of the Bundesliga game between FC Bayern Munich and SV Werder Bremen on April 26, 2014 took place as part of an internal test run and was encoded…
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