New study reveals how human astroviruses bind to humans cells and paves the way for new therapies and vaccines Human astroviruses are a leading viral cause of the stomach bug—think vomiting, diarrhea, and fever. It often impacts young children and older adults, leading to vicious cycles of sickness and malnutrition, particularly for those in low and middle income countries. It’s very commonly found in wastewater studies, meaning it’s frequently circulating in communities. As of now, there are no vaccines for…
Chemist at LIKAT Defines Standards for Light-driven CO2 Reduction. The first standardization document for photocatalytic synthesis was created with the significant participation of a chemist at the Rostock Leibniz Institute for Catalysis, LIKAT. Called “DIN SPEC 91 457”, the specification lays down concrete guidelines for a so-called CO2 reduction, which is a reaction in which important basic materials for the chemical industry are produced from CO2 and water (H2O) by means of catalysis. “These guidelines strengthen our global efforts to…
… reveals what drives their first movements. Bringing ultrafast physics to structural biology has revealed the dance of molecular ‘coherence’ in unprecedented clarity. How molecules change when they react to stimuli such as light is fundamental in biology, for example during photosynthesis. Scientists have been working to unravel the workings of these changes in several fields, and by combining two of these, researchers have paved the way for a new era in understanding the reactions of protein molecules fundamental for…
LJI and Augusta University scientists investigate link between “deprogrammed” regulatory T cells and cardiovascular disease. Scientists can finally hunt down a harmful kind of human T cell, thanks to new research led by scientists at La Jolla Institute for Immunology (LJI) and the Medical College of Georgia (MCG) at Augusta University. Immune cells called ex-T regulatory cells (exTregs) tend to be rare in the body and, so far, impossible to detect in human samples. The new study gives scientists a…
In the refrigerated grocery store aisle, meat alternatives greatly outnumber plant-based seafoods. But more mock seafood options are needed because of unsustainable fishing and aquaculture practices, which can deplete the supply and harm the environment. Today, researchers present a new approach for creating desirable vegan seafood mimics that taste good, while maintaining the healthful profile of real fish. They 3D-printed an ink made from microalgae protein and mung bean protein, and their proof-of-concept calamari rings can even be air-fried for…
Imagine using insects as a source of chemicals to make plastics that can biodegrade later — with the help of that very same type of bug. That concept is closer to reality than you might expect. Today, researchers will describe their progress to date, including isolation and purification of insect-derived chemicals and their conversion into functional bioplastics. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). ACS Fall 2023 is a hybrid meeting…
Catalysis scheme developed at the University of Bonn is inexpensive, sustainable, and effective A novel catalysis scheme enables chemical reactions that were previously virtually impossible. The method developed at the University of Bonn is also environmentally friendly and does not require rare and precious metals. The researchers recorded the exact course of the catalysis in a kind of high-speed film. They did this using special lasers that can make processes visible that last only fractions of a billionth of a…
For now, cyborgs exist only in fiction, but the concept is becoming more plausible as science progresses. And now, researchers are reporting in ACS’ Nano Letters that they have developed a proof-of-concept technique to “tattoo” living cells and tissues with flexible arrays of gold nanodots and nanowires. With further refinement, this method could eventually be used to integrate smart devices with living tissue for biomedical applications, such as bionics and biosensing. Advances in electronics have enabled manufacturers to make integrated…
A study published on August 10, 2023 in the journal Nature Communications has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells. The researchers also identified three proteins that are needed for the virus to carry out the invasion and have in turn synthesized molecules (potential drugs) that can target one of the proteins, potentially leading to new…
Our Very Own Skull… Alzheimer’s, stroke, multiple sclerosis and other neurological diseases cause severe damage due to neuroinflammation mediated by immune cells. Managing this inflammation poses a significant medical challenge because the brain is protected by the skull and additional surrounding membranes that make the brain less accessible for treatment approaches. Scientists had previously discovered pathways going from the bone marrow of the skull towards the brain, allowing immune cell movement. Now, new research revealed that cells in the skull’s…
LJI researchers reveal a hidden side of how Ebola virus replicates inside host cells. New research in the journal Nature Communications gives scientists an important window into how Ebola virus replicates inside host cells. The study, led by scientists at La Jolla Institute for Immunology (LJI), reveals the inner workings of “viral factories,” clusters of viral proteins and genomes that form in host cells. The research team, which included experts from Scripps Research and UC San Diego School of Medicine,…
UC San Diego study shows hematopoietic stem cell transplants can protect against memory loss, neuroinflammation and β-amyloid build-up in Alzheimer’s mice. In the ongoing search for a cure for Alzheimer’s disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system. In a new proof-of-concept study, scientists at University of California San Diego show stem cell transplants may also be a promising…
Scientists from the Keck School of Medicine of USC identify key cells involved in the process of cartilage regeneration in lizards— a discovery which could offer insights into novel approaches to treating osteoarthritis. A team of researchers from the Keck School of Medicine of USC have published the first detailed description of the interplay between two cell types that allow lizards to regenerate their tails. This research, funded by the National Institutes of Health and published on August 10 in Nature…
While engaging in cell division research, Silke Hauf and members of her lab made a surprisingly quiet discovery. When cells express RNA, there is always some fluctuation, or noise, in how much RNA is produced. Hauf’s group found several genes whose noise dips below a previously established threshold, known as the noise floor, during expression. “We have solid data for this phenomenon,” said Hauf, associate professor in the Department of Biological Sciences at Virginia Tech. “There are some genes that are…
Researchers identify novel gelatinase substrates involved in astroglial barrier function: In neuroinflammation, immune cells such as leukocytes cross the blood-brain barrier. One key to this is the gelatinases matrix metalloproteinase (MMP)-2 and -9. Until now, the substrates of these enzymes involved in the process were unknown. Now, using a sensitive mass spectrometry-based secretome approach, researchers at the University of Münster and Bonn University Hospital (UKB) have succeeded in identifying hundreds of such molecules that are cleaved from the cell surface…
Developing new materials requires significant time and labor, but some chemists are now hopeful that artificial intelligence (AI) could one day shoulder much of this burden. In a new study in the Journal of the American Chemical Society, a team prompted a popular AI model, ChatGPT, to perform one particularly time-consuming task: searching scientific literature. With that data, they built a second tool, a model to predict experimental results. Reports from previous studies offer a vast trove of information that…
Scientists to reveal the atomic-level workings inside the crushing and grinding of mechanical chemistry, with the potential to scale up their advances to make chemical manufacturing more sustainable and cost-effective. CUNY ASRC researcher Adam Braunschweig’s lab is part of a newly awarded $20 million center from the U.S. National Science Foundation to understand the atomic-scale mysteries of “crushing” chemistry. The multi-institutional award will establish the Center for the Mechanical Control of Chemistry (CMCC), which will conduct work to understand how…