Electrical precipitators are used to precipitate particles out of gas streams in a process for which the electrical resistance of the particles plays a decisive role in how the precipitator functions.
An electrical precipitator is suitable for precipitating particulate matter with a specific electrical resistance within a range from 10⁴ to 1011 Ωcm. Particulate matter with higher electrical resistance causes what is called a “back corona”, which severely disrupts the precipitation process.
Distillative separation, particularly of thermolabile volatile substances, is often associated with a significant reduction in quality due to the thermal degradation of the substances being distilled. For example, many substances containing plant matter, such as essential oils, can scarcely be distilled without degradation.
State-of-the-art distillation methods are based mainly on steam distillation as a carrier steam distillation for primary extraction, which merely results in a complex mixture of substances as essential oil.
The expression and production of recombinant proteins in bacteria, such as E. coli is a long standing and well known procedure. However, expression in bacterial systems is limited due to cytoplasmic accumulation of the protein of interest (POI). Even though, various attempts have been made to prevent the accumulation of the desired protein in inclusion bodies, there is still no satisfactory solution available to overcome this problem. The present invention enables the expression of POI on the cell surface of bacteria, thereby preventing the cytoplasmic and periplasmic accumulation.
Aptamers are short, single-stranded DNA molecules that can specifically bind proteins due to their three-dimensional structure.
Because of their ability to deactivate different protein functions inside the cell, aptamers are already used successfully in the field of medical diagnosis, as therapeutic agents and in environmental analytics.
So far the technical production of single stranded DNA (ssDNA) within the range of more than 60 n has been linked to a grand
percentage of abbreviated respectively functionless by-products. Bigger aptamers with even 100 n or more have only been
practicable facing great loss of quantity of material. Within the case of aptamers, an exact sequence identity is essential for
technical application, though.
By use of the described technology it is now possible to produce aptamers in the range of 100 n and beyond in unmatched quality and quantity via a multi-copy-fragment (“AptaGENE”), using a combination of both in vitro and in vivo techniques.
[Reference UKL221]
There are no basic technologies for nano-particles available, which are suitable for medical application. The present invention offers such a new technology, which is deal-ing with a bifid copolypeptide consisting of one hydrophilic polysarcosine and one hy-drophobic polycysteine part. The hydrophilic polysarcosine part prevents an unspecific binding on proteins, increases the solubility in the serum, and no immune reaction will be activated. Thus it is an ideal protection for encapsulated drugs.
The polycysteine part forms autonomous micelles in polar solvents, which are stabi-lized by cross linked disulphide bridges. The resulting micelles are stable in blood, in the cytosol, against glutathione and also survive endocytosis of antigen presenting cells or macrophages.
When the disulfide bonds were cleaved by metabolization, the copolymer loses its sta-bility and the active ingredient will be re-leased.
[Reference UMZ314]
Cancer is still the main cause of death despite
the development of many treatment
strategies, including extensive radiation and
chemotherapy. Clinical and research results
from animal test have shown that, besides
viruses, bacteria and parasites, the T-cell
system can also recognize malignant abnormal
cells and is able to destroy those.
Especially CD8+ T-cells (cytotoxic T lymphocytes,
CTLs) can cause responses of
tumor repulsion by the recognition of antigens
that are presented on the cell surface
by Major Histocompatibility Complex Class I
molecules (MHC, in humans HLA Class I).
This invention offers the application of HLAindependent
recognition of tumorassociated
antigens for diagnosis, therapy
and prevention of melanoma and other tumor
types. Two antigens are presented that
can be recognized by CTLs independently
of HLA and whose application in cancer
immune therapy will unlock new therapy
alternatives.
[Reference HMZ077]
T lymphocytes present HLA molecules on their surface. The allogeneic transplantations of blood cells could lead either to a required graft- versus- leukaemia/ tumor reaction (GvL/T) or could result in an undesired graft-versus-Host-Disease (GvHD). If there is a complete HLA-match, these effects could result from minor histocompatibility antigens. The present invention deals with an unknown mHAg. Studies have shown that T cells from one donor, which were coincubated with leukaemia cells (homozygous for HLA- molecules), could induce specific T cell responses. Accordingly these results refer to an immunogenic mHAg. A minor- mismatch could lead to a GvH- Disease or to positive GvL reactions. In the first case a tissue typing from donor and recipient could minimize the risk of a GvHD. In the second case the preferable GvL-/ GvT- effects could be increased through a transfer of antigen specific T cells or T cell receptors by inoculation.
Compared to conventional memory modules Magnetic memory cells have the important advantage that they do not need permanent current supply to save data, they only need current to change the information of the memory module. At present several MRAM technologies are beeing developed.
In the present memory the fact is used that on short time scales the course of the magnetization in a switching event is governed by precession. In the case of long writing pulses (e. g. >10ns) the switching properties are dominated by dissipative mechanisms, which is demonstrated in Fig. 1 by the clear boarder line between switched and non-switched regions. For shorter writing pulse durations the switching properties will be affected largely by the precessional properties of the magnetization. In particular the actual direction of the magnetization vector at pulse termination will determine the bit status stored in the memory cell. This is shown in Figs. 2 to 4, which show an increasingly more complex switching scenario with decreasing pulse duration, evidenced by the more complex boarder line between the regions of switching and non-switching.
On the basis of these ideas there have been realized a concept for an MRAM with very short switching times, which is optimized for maximum switching reliability and minimum power consumption
Adenosine is a modulator of many physiological and pathophysiological processes in the central nervous system (CNS). Blockade of the adenosine receptors A1ARs and A2AARs has shown beneficial neuroprotective effects in animal models and in clinical studies of Parkinsons’s disease (PD) and Alzheimer’s disease (AD). There is still no satisfactory multitarget drug approach which inhibits MAO-A and the two adenosine receptors A1ARs and A2AARs. This invention provides newly designed tricyclic xanthine derivatives which allow overcoming this problem. A variety of 69 derivatives were prepared and evaluated in radioligand binding studies at adenosine receptors and for their ability to inhibit monoamine oxidases. Potent dual-target-directed A1/A2A adenosine receptor antagonists were identified. Several compounds even showed triple-target inhibition.
The co-stimulatory CD40-CD40L dyad is crucial in the development and progression of immune responses and chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis. However, long-term antibody-mediated inhibition of CD40L or CD40 is not clinically feasible as it results in thromboembolic events and severe immune suppression. More downstream inhibition of the CD40L-CD40 pathway is therefore preferable, especially tumor necrosis factor receptor-associated factors (TRAFs) recruited by CD40. Here we created a set of inhibitors that selectively block CD40-TRAF6 interactions. The rest of the CD40 cascade is left unaffected preventing unwanted immune-suppressive side effects. Therefore, our new inhibitors offer promising candidates as therapeutic agents for the treatment of chronic inflammatory diseases, such as atherosclerosis, obesity and multiple sclerosis.
Experiments at the University of Bonn have shown that the expression of MED15, a subunit of the trans-criptional co-regulator Mediator, correlates with the proliferative activity of cells. MED15 is essential for TGF-ß-signaling and control of cholesterol/lipid homeostasis. The protein shows low frequency in androgen-sensitive prostate cancer and lacks expression in benign prostatic tissue.
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system and various other organs. In patients, lipid storage causes a progressive loss of myelin leading to various neurological symptoms. The sulfatide storage in ASA-deficient mice is comparable to humans, but the mice do not mimic the myelin pathology.
Therefore, transgenic ASA-deficient (tg/ASA(-/-)) mice were generated overexpressing the sulfatide-synthesizing enzyme galactose-3-O-sulfotransferase.
Tool coils for or magneforming (or electromagnetic forming = EMF) of complex, 3D shaped parts were previously wound from wires or produced by complex
processes such as milling and wire eroding. The milling process is necessary to produce the outer contour. Wire eroding is used to create the winding structures,
whereby it should be noted, that a 3D design is very limited. The invention concerns to special coils
for EM forming and for a method for their production, wherein the current-carrying coil body is additively manufactured using a rapid prototyping method (laser
melting, etc.).
<b>Background</b>
Protein kinase C zeta (PKCζ) is implicated in the development of several inflammatory diseases and a promising therapeutic target. PKCζ controls TH2 response and is important for the regulation of NF-κB transcriptional activity. Moreover, there is increasing evidence for an involvement of PKCζ in tumor development, where it controls chemoresistance and cancer–related inflammation.
<b>Invention</b>
Scientists of Saarland University and German University in Cairo have discovered 1,3,5-trisubstituted and 1,3,4,5-tetrasubstituted pyrazolines as a potent and selective class of allosteric PKCζ inhibitors. Several of the compounds show inhibitory activity in the nanomolar range. The compounds have an allosteric mode of action by binding the less conserved PIF pocked domain and are highly selective for the specific PKC isoform.
<b>Applications</b>
The present technology opens up an innovative therapeutic approach for the treatment of inflammatory diseases in which the identified compounds can serve as starting points for drug development. First experiments indicate relevance particularly for chronic obstructive pulmonary disease (COPD).
<b>Advantages</b>
• Innovative potent small molecules for selective PKCζ inhibition
• Allosteric mode of action increases selectivity
• Highly versatile scaffold for the independent optimization of four substituents
• Specific targeting may contribute to fewer side effects
• Potential treatment of diseases with high unmet medical need
We propose a fundamentally new, direct solution for real-time monocular SLAM/Odometry (VO). The method runs in real-time on a laptop CPU or modern smart phone. In addition to accurate and robust camera-tracking, it estimates precise, semi-dense depth maps.
The invention describes SiC/Graphene Transistors for Normally-On/Normally-Off Operation and Integrated Circuits (Including Logic). This invention can be used, e.g. to
build a compact constant current source for LED-lightning,
include the control circuits and the LED on the same SiC-subtrate and/or provide control circuits for high power switches.
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