The invention allows placing structures specifically in the centre of the depressions in the nanometer range. The specific binding in the centre is particularly suited for single-molecule applications, single-molecule sequencing and other high-throughput methods.
clamping system with integrated shoulder element for friction stir welding.
Unique nano-seals allow for forgery-proof object identification. Due to a combination of ion irradiation and simultaneous co-deposition of metal atoms a unique surface pattern is created. Its manufacturing process and its size of only a few square micrometers make it impossible to be reproduced, thus creating a forgery-proof identifier.
A method and components to fibre-couple multiple light sources in a highly efficient way is proposed. The new technique simplifies the process with which a side coupling arrangement for a double-cladded target fibre can be realized. In addition it improves the coupling efficiency compared to the so far existing state of the art.
Hybrid plasma-laser micro-structuring provides a tool for treating fused silica without the need for a time consuming preconditioning of the surface or the use of expensive vacuum-UV- respectively mid-wavelength-IR-lasers. The use of a hydrogenous plasma prior to the ablation process causes a temporary increase of the absorption in a more easily accessible wavelength region.
The invention describes a procedure to improve fluid mechanically the efficiency of chemical reactions and methods for emulsification and dispersion. This is done by generating hydrodynamically oscillating cavitations in a very efficient and homogenous way.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third most common cause of cancer related death worldwide. Cure of HCC is only possible by complete resection in early stages, but only 10–20% of tumors can be curatively resected and the risk of HCC recurrence is high. In addition, HCC is resistant to conventional radio- or chemotherapy. As a result, the prognosis of HCC remains poor and new therapies are urgently needed. The discovery of so far unknown immunodominant epitopes of the tumor-associated antigen Glypican-3 and the according HLA-A2 restricted T-cell-receptor enable the development of an adoptive T cell therapy for HCC patients. Adoptive T cell therapies showed very promising results in cancer therapy over the last years. The Science Magazine even awarded this technology as “Breakthrough of the year 2013”. Therefore, the current invention provides the tools for a promising new approach for the therapy of HCC.
The novel pH value sensor works according to an optical electrochemical principle and comprises a photoluminescent or fluorescent layer, a light source and a detector. The layer comprises an electric potential and acts as a working electrode which is implemented as a nanostructure (nanowires with quantum dots). Furthermore, spatial resolution can be achieved by using numerous nanowires contacted individually on a carrier and a visual array detector (analogous to CCD sensors in digital cameras).
Other reactions or concentrations of substances can also be detected.
This novel sensor works according to an optical electrochemical principle and comprises a photoluminescent or fluorescent layer, a light source and a detector. The layer comprises an electric potential and acts as a working electrode which is implemented as a nanostructure (nanowires with quantum dots). Furthermore, spatial resolution can be achieved by using numerous nanowires contacted individually on a carrier and a visual array detector (analogous to CCD sensors in digital cameras).
Currently, continuous fibers in the form of woven or braided structures are used as reinforcement of oxide fiber composites. For the first time, short-fiber reinforced oxide fiber composites with a bending strength of more than 100 MPa can be fabricated. A short-fiber preform made of stapled fiber bundles fulfills the demand of a high fiber volume content, which is required to adjust good mechanical characteristics.
The invention describes a process which enables the separation of permanent magnets out of a crap mixture. In order to achieve this thermal treatment is realized which leads to a partly demagnetization. This enables the following separation in an alternating magnetic field. This process leads to a separate fraction of corresponding permanent magnets. A German as well as an international patent application are pending.
An experimental plant is build up. A proof-of-concept is realized. On behalf of the Westphalian University of Applied Sciences PROvendis offers licenses to interested companies.
This invention concerns a device for internal high-pressure forming of micro-components from tubular moulding blanks. In this novel design, a carriage is sliding along guides, moved by a drive mounted separately from the guides. Hereby, the drive is coupled to the carriage free of any transverse forces. This minimises elastic deformations. Bending stresses in the plungers are avoided. The relative position between guide and forming tool is maintained.
The functional capability of the invention has been proven in many tests. Patents are granted in USA, Germany, France, Great Britain and Suisse. PROvendis is offering licences of the invention to interested parties on behalf of Cologne University of Applied Sciences.
This invention presents a process and an apparatus for the production of water-insoluble lignin granulates for material and energetic usage.
Pulp extraction for manufacturing paper from wood or grasses generates lignin, which has a high calorific value, in large amounts as a side-product and component of waste liquor.
The further use of lignin is prevented especially because of heterogeneity, aroma, water solubility, dust formation, and high reactivity.
This invention proposes a method to make plants more resistant to (repeated) heat stress. This is done by means of using microRNA156 (miRNA156) to increase heat stress tolerance. miRNA156 is expressed under the control of a special heat-inducible promoter to minimize negative side effects such as enhanced leaf induction and later flowering. The proposed invention expresses miRNA156 exclusively by means of heat. The heat-inducible promoter HSP21 ensures that the expression of miR156 is “switched on” by
the application of heat.
This invention describes “solid-state” sensors with electrical control of the affinity of chemosensitive materials. This configuration enables rapid regeneration of sensors after analyte binding and increases selectivity. The sensor has been designed as a six-electrode chemoresistor that contains four electrodes in the center for separate measurements of resistance as well as two other external electrodes to monitor the redox status of the sensor material.
This object is accomplished in the format of a solid-state chemosensor.
This innovation comprises a novel measurement device which uses the structure-
borne noise of a moving component to detect whether there is a fault in it. The
methods used up to now have specific disadvantages in their current application.
Normal spectrum analyses of structure-borne noise, for example, usually rely heavily
on assumptions about the operating environment, are highly computer-intensive and
are effectively blind to weak and static signals with an unstable phase position.
The novel measurement device bases its analysis on the entropy value calculated
from the probability of the different frequencies of the structure-borne noise. A
possible fault can therefore be detected at an early stage and in a reliable manner
without any additional assumptions.
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