The invention relates to a constructive alteration of the ultrasonic transducers for an ultrasonic reflection and transmission measurement. The core of the invention is the placement of the transducers in a U-form with several ultrasonic transducers on the inside, which allow the measurement of irregular bodies and bodies with high ultrasonic dampening. Additionally the device uses constant flow of coupling agents by pumps. Several openings on the inside provide the testing body with a suitable agent with ensures the required coupling of the materials.
The present invention using the acoustically induced laser scattering (ALS) avoids these disadvantages by applying the principle of the acousto-optical modulation. By an appropriate arrangement of an ultraultrasonic source, a sonic grid which diffracts laser light is generated in the material. By exclusively using the diffraction peak of
the laser light in a test object, the invention enables new possibilities of non-invasive determination of relevant rheological and other mechanical properties. With this method, a non-destructive measurement of little technical effort and very short measuring times gets possible. Especially
it is, in contrast to conventional rheometers, suitable for in situ measurements. Thus, the invention has a big market potential in the fields of materials science, materials testing and quality assurance.
The invention delivers a solution, which is an energetically and ecologically better method, along with the required device for separating carbon dioxide from the exhaust fumes of combustion engines, based on thermodynamic arrangements. To do so, the gas mass, which is fed to and exhausted from the engine is conditioned in such a way that it is possible to lower the exhaust conditions enough for 〖CO〗_2 condensation. The conditioning is done in regards to temperature and pressure. Doing so causes the carbon dioxide to change its aggregate state to liquid, which makes separation and storing of 〖CO〗_2 possible. The energy for this process is taken out of the engine exhaust and from the engine power. The energy exchange is done with heat exchangers. An additional medium is used as heat storage, while the enthalpy of this medium can be used for recovery processes.
It is known, that the electric stimulation of the Stapedius muscle by the brain is not following a 0-1 scheme. Rather, it is following in a continuous curve which correlates with the signal intensity. Because of this, the invention aims to deliver a method for continuously (re-) calibrating every amplification factor.
The invention solves this task by using an integrated control system. This system compares the outer microphone volume with a target curve, which causes the Stapedius muscle to behave in a certain way. If the measured muscle behavior is different from the expected one, this system changes the amplifying parameters.
By observing and storing the Stapedius activity it is possible to make the amplification factors dependent on the volume, which makes a nonlinear amplification possible.
The present invention refers to a method and a device for improving
a person‘s mobility. It is designed as a mobile, technical platform
offering space for one person being moved with power assistance,
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The invention relates to a method which produces repeated and reproducible 4D-movements of a phantom model for measurements in PET, SPECT, CT and radio oncologic accelerators. According to the invention, the usable phantoms illustrate realistic tumor geometries with-out interfering glass and plastic partitions. With the help of the invention, PET-, SPECT- and CT-data can be evaluated. Additionally new algorithms of re-construction and the influence of ana-tomic movements on medical imaging can be tested for all of the three tech-niques. With the help of a kinematic con-catenation which consists of two rota-tional and one prismatic joint, the 3D-movements of the phantom models can be adapt on trajectories analog to the human respiration.
The present invention describes a measur-ing device that allows for the accurate de-termination of intraocular pressure by attaching a measuring body to the closed eyelid. The measuring principle is based on the subjective intraocular pressure es-timation by the palpating finger and will be implemented in an objective measuring method by the device described herein.
The existing development is based on an approximation of the contour of the in-dented eye which flattens the enveloping tissue and simultaneously adapts to the contour of the eye’s surface. In the broad-est sense it is as an adaptation of covering eyelid tissue to an expanded surface of the eye. The device basically consists of two pressure units made from silicone, which are independently and resiliently mounted from another. The pressure of the first membrane is applied via a struc-turally designed spring and serves to smooth the upper eyelid and the indirect fixation of the eyeball. The pressure of the second membrane is applied via two springs and is continuously increased to-wards measurement point when no further flattening of the second membrane is visi-ble. Consequently, the pressure character-istics of the eye are transferred from the first membrane to the second membrane. The flattening is monitored by an LED light reflex and the maximum value can thus be easily determined.
The present invention is of particular ad-vantage for measurements of intraocular pressure in patients with an injured or dis-eased cornea.
This steel mounting part provides a fully rigid connectiv ity between tubular composite column and reinforced concrete slab.
Simultaneously, it solves punching shear problems in the reinforced concrete slab by increasing its shear capacity.
The invented substances have been characterized with regard to the inhibition of the cPLA2 (IC50 in the submicromolar range) and metabolic stability (tested in rat liver homogenates). The inventors are currently conducting such experiments with further, newly generated derivatives of the same inhibitor family. On behalf of the Westfalian Wilhelms-University of Muenster, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development. The cPLA2 has been identified as target for the inhibition of inflammatory immune responses. The invented substances are of high interest for any pharma company with an immunological pipeline and may constitute the first-in-class cPLA2 inhibitors for systemic application.
Parkinson's disease (PD) is a neurological movement disorder. Atypical Parkinson syndromes arise from other neurodegenerative diseases like Dementia with Lewy bodies (DLB). The accurate distinction between them is challenging. Our scientists developed a new diagnostic test to differentiate between DLB, PD and other neuropathies.
For two-dimensional film thickness determination, a measurement system based on a hyperspectral imager has been developed for the first time. A head forms a measurement line. Reflection of the measurement object is displayed on the entrance slit of the hyperspectral imager. From the spectral reflectance data of each locally resolvable pixel of the examined object the layer height is reconstructed. If the measurement object is moving uniformly, combined measurement lines are resulting in a two-dimensional measuring surface. In addition, for each locally resolvable pixel the distance between head and measurement object can be determined.
According to the International Diabetes Federation (IDF), diabetes affects close to 400 million people worldwide and caused 500 billion Euros in health expenditure in 2013. In preclinical and clinical trials, the NMDA receptor antagonist dextrorphan (DXO) and its prodrug dextromethorphan have been shown to harbor antidiabetic properties (Marquard et al., Nat Med 2015). In addition, DXO was shown to protect mouse and human pancreatic beta cells from cell death during a diabetogenic setting.
DXO is well tolerated and sold as over-the-counter (OTC) medication for more than 50 years. However, adverse events are observed, which are likely caused by the action of DXO on the central nervous system (CNS). Here, the scientists developed DXO-derivatives that do not efficiently pass the blood brain barrier (BBB), and thus should cause fewer adverse effects on the CNS, but maintain their antidiabetic properties. Therefore, the derivatives might maintain the good safety profile and antidiabetic properties of its starting substance dextrorphan, but with fewer adverse effects.
The inventors now aim to demonstrate the expected novel clinical benefit in clinical studies.
The present invention refers to a method and a device for improving a person‘s mobility. It is designed as a mobile, technical platform offering space for one person being moved with power assistance.
In contrast to the already known mobility equipment, the technical basis of the inventive mobility platform consists of “rolling legs“ known as whegs (“wheg“ = wheel-like leg / wheel a leg / wheel-legs). These whegs combine the positive features of wheels and legs. To antagonize disturbing effects of alternation, a force coupled mechanical solution is applied.
Funded by the Baden-Württemberg Stiftung gGmbH, KIT (Karlsruhe Institute of Technology) and Ulm University scientists have developed a procedure that enables the targeted modification of surfaces' friction and adhesion properties through irradiation with light. Depending on the application the modification may be irreversible, i. e. properties are adjusted once-only, or reversible, i. e. facilitating a switch between the minimum and maximum coefficient of friction in a selective and continuous manner. Therefore, the new technique opens up new opportunities for photo-activatable and photo-switchable applications even in the field of micro and nano systems technologies.
The invention provides a solution that makes it possible to reduce the number of individual steps during the production of patient specific braces.
The inventive production of an orthodontic appliance is possible because of the combination of the latest computer technologies and the use of an additive manufacturing process. To get a three-dimensional computer model of the jaw an oral scanner is used. The 3D model makes is possible to use generative manufacturing such as 3D printing for the production of patient specific braces.
To fix the appliance on the teeth, the invention allows using ultrasound to directly incorporate lowering wire elements into the plastic base. Due this combination of dental volumetric tomography and finite element linking, it is possible to get an individualized load simulation.
The invention allows a selective extraction and analysis of cells from defined positions within natural or artificial three-dimensional structures without destroying the cell culture medium. This is achieved by a cell reactor having an upper part and lower part which are detachably connected together as well as inflow and outflow openings for liquid or gaseous nutrient medium. The flow through the cell culture with cell medium can be carried out both apically and basally. Furthermore, the reactor has a layer system with layer basket for receiving the cell culture carriers in the form of layers and positioning them along a fixing ring. The layers can have different geometric shapes and can be made out of different materials and are also reus-able.
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