The invention describes a system, which is used to monitor the ingrown and loosening status of an implant.
To achieve this, body sound and ultrasound sensors are placed on the surface of the prosthetic. These sensors are able to detect micro friction processes, caused by a relative movement between the artificial hip and the surrounding soft and hard tissue. In addition, the system is capable of using ultrasound to monitor the ingrown and loosening status.
By doing so, the invention delivers a measurement system for a non invasive and radiation free examination of the loosening and the ingrown status of hip replacement implants. This system would be able to reduce the number of unnecessary revision surgeries and thus could be able to reduce the costs caused by such opera-tions.
The invention delivers a new constructive design of the ultrasonic transducers to enhance the usability of ultrasonic material testing. The device described in the invention is constructed with a great number of piezo electric transducers on the surface of the probe. Those piezo electric elements are placed like mosaics on a flexible surface, which is placed on a rodshaped carrier. This surface is now able to adapt to the surface of the testing body, which means that a great number of complex surfaces can be tested with this system.
The carrier includes several channels, which are able to constantly supply the ultrasonic transducers with a gel. This gel is used as the coupling agent for an opti-mized sound transfer.
A solution for the known difficulties is given with this invention. Therefore a rotating valve is described. This valve controls the fluid flow in the system without getting in touch with the fluid itself. To do so, the valve heads are pressed on the flexible fluid pipes, which causes the flow through this point to stop. The valve heads are moved by electrically con-trolled actuators which perform a rotation movement. Unlike with membrane valves, additional energy to keep the valve open or closed is not required. Furthermore it is possible to use miniature servo actuators for the movement of the valve heads.
The invention relates to a system, in which the flow in the channel is caused by a contact device, which is not in direct contact with the fluid. The flexible fluid channel is compressed by force which leads to closure of the channel. Now the contact device is moved along the chan-nel which causes an internal wave that transports the fluid. The pump itself emits force onto the channel without being a part of it. By doing so, it is possible to use the pump with one time use systems, because it is possible to remove the pump from the system without the need of disconnecting the pump from any channel attachments. Furthermore it is possible to reuse the pump system which helps to reduce costs. Furthermore it is possible to use this pump together with aggressive solutions, because the pump itself is not in any contact with the fluid.
The invention is based on a measuring device consisting of a transmitter and two receivers. The transmitter transmits a sinusoidal signal, which is band pass filtered, amplified and converted into a squarewave signal. Depending on the distance of the transmitter to the individual receivers, the received signals have a certain phase shift in relation to each other and now enter two inputs in the actual measuring system. On the lines, a signal is sampled and each fed to a XOR gate at regular intervals. There, a logical “1” is passed, if only one square-wave signal was received. The duration of the “1” indicates the relative phasing of the input signals at the physical tap. Each XOR gate passes its signal to a counter connected to the system clock. At each clock, the counters who received during clock rise just a “1” from the XOR gate are incremented by one. The results of the individual counters vary, but take in a minimum of one place. As a result, the transmitter can clearly be located after calibration.
The invention relates to a method for email communication based on the exchange of MX-Records (Mail-Exchange-Records).
With the invention, those public MX-Records get controlled and verified by a more complex MXK-Record (Mail-Exchange-Key). Generating those keys can either be done by every person themselves or by a central position. These generated keys only need to be digitally signed by the service provider. The provider itself is not included in the process of generating the keys, which means he is not faced with additional expenses. Because no third party is required to generate the key, this method is an easy to use and secure method for the encryption and sending of emails.
With some modifications, this technique is also suitable for the encryption of telephone or SMS communication.
An apparatus for holding back, and diverting, fish in bodies of water by the arrangement of parallel cables braces between two or more abtuments, wherein the distance between the cables is small enough to prevent fish from swimming through the apparatus
We have developed a new method for improvement of cellulase and hemicellulase production in Trichoderma reesei by overexpression of a developmental regulator.
The present invention specifically provides a novel vaccine formulation
suitable for ocular immunization and provides a method for inducing a local and systemic immune response. The combination of the three components antigen & corpusculate bodies (eg.Bortedella pertussis (wBP)) & adjuvans showed the highest rise in IgA antibody titers in tears and sera when compared to other immunization groups. Immunization via the conjunctiva with TTd plus wBP and adjuvant resulted in a 33% survival rate of challenged mice compared to a 0% survival rate in non-immunized animals.
USE OF ERYTHROPOIETIN FOR THE TREATMENT OF
FRIEDREICH´S ATAXIA:
In addition to its neuro- and cardioprotective properties recombinant human erythropoietin (rhuEPO) significantly increases frataxin expression in primary lymphocytes from FApatients, and other cell types like neurons and primary human cardiac cells in vitro. (Sturm et.al 2005, Eur. J.Clin. Invest. 35(11):711-7) rhuEPO was successfully tested as a treatment for Friedreich`s ataxia in Phase IIa/IIb and dosefinding studies.
Pathological calcification processes in the human body are often the
beginning of a series of diseases which relate to organ systems such as the vascular system of the heart, and kidney. As a consequence of metabolic diseases such as diabetes, calcification processes can lead to severe impairments of health or to death. Therefore, it is of scientific and economical interest, to develop new approaches for quick and inexpensive treatments of these diseases. Already known calcification biomarkers provide an indication of occurring calcification processes but still can’t make a statement about triggering factors, which will be possible with our in vitro calcification model, CALCI-QUICK.
Researchers of the Medical University of Vienna have identified highly
active synthetic chalcones derived from the chalcone scaffold. These
cytotoxic compounds were found and developed by modifying the
chalcone lead structure concurrent with in vitro tests to evaluate their
cytotoxic potential in different cancer cell lines. Compounds were
thoroughly tested regarding their efficacy in inhibiting proliferation and
viability in cancer cell lines of the hematopoietic system. The combination of the new chalcone compound with the targeting agents, Idelalisib and Ibrutinib, which are novel compounds in the treatment of hematological malignancies, displayed higher cytotoxicity on CLL cells than Idelalisib and Ibrutinib alone.
The proposed methodology is an important step towards image-analysis
based individualization of patient management and treatment in one of the most cost-intensive fields of modern medicine. We propose to
identify and quantify retinal morphology using deep learning algorithms
such as convolutional neural networks (CNN) and to predict future
disease progression patterns and treatment response in patients based on spatio-temporal signatures.
At University of Bremen a new wound healing strategy has been presented: The team of the Wound Repair Unit at the Centre for Biomolecular Interactions Bremen (CBIB) has shown the influence of lung surfactant on keratinocytes and the benefit of these interactions for cell migration and wound resurfacing. Lung surfactants contain phospholipids and surfactant proteins and are used as standard therapy for respiratory distress syndrome in preterm infants.
There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation. The invented substance and protocol is routinely used by the inventors and has thus been shown to be robust for general laboratory usage.
On behalf of the University of Duisburg and Essen, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit. In case of interest we will be pleased to inform you about the patent status.
The present invention relates to a plant and a procedure for separating gold or other metal particles from a mixture of particles by applying dielectrophoresis. The physical separation method specifically separates metals, e.g. gold, from a suspension. This is accomplished by a special configuration of electrodes allowing for the creation of an electric field which is selective to metallic particles. The new method replaces environmentally hazardous cyanide leaching almost completely and thus considerably reduces the amounts of the chemicals that need to be applied.
Feedback
