Scientists at the Research Institute of Molecular Pathology and collaborators have investigated how different forms of cancer therapy can influence the efficacy of subsequent therapies. They found that administering targeted therapy, drugs which target mutated cells, could jeopardise the effectiveness of immune stimulating immunotherapies in skin cancer patients – an important finding as these treatments are often given to patients in this sequence. This phenomenon, called cross-resistance, highlights the need to understand how therapies shape tumours. The researchers’ findings, now…

The human recombinant anti-SARS-CoV-2 antibody COR-101 was developed in close cooperation of Technische Universität Braunschweig, the Helmholtz Centre for Infection Research (HZI) and the biotech company YUMAB GmbH in Braunschweig. The antibody is currently undergoing phase Ib/II clinical trials for the treatment of moderate to severe COVID-19 by CORAT Therapeutics GmbH. The story of the discovery and development of this antibody was now published in the Journal “Cell Reports”. In the first step, the genetic information of immune cells, which…

Scientists from three Max Planck Institutes (MPI), the MPI for Medical Research in Heidelberg, the MPI for Marine Microbiology in Bremen and the MPI for Biophysics in Frankfurt and the Radboud University in Nijmegen have successfully determined the structure of the enzyme which produces a large part of the nitrate on earth. Microorganisms use this enzyme, called NXR or nitrite oxidoreductase, to convert toxic nitrite into nitrate. Both nitrite and nitrate are forms of nitrogen that have a major impact…

Cells, like many of us, fend off germs with cleaning products. Researchers have discovered that a molecule made throughout much of the body wipes out invading bacteria like a detergent attacking an oily stain. This killer cleaner, a protein known as APOL3, thwarts infections by dissolving bacterial membranes, Howard Hughes Medical Institute Investigator John MacMicking and his colleagues report in the journal Science on July 15, 2021. His team tested the protein on the food-poisoning bacteria Salmonella and other similar…

A team of researchers led by Prof. Dr. Cornelia Denz from University of Münster has developed a simplified method to perform the necessary calibration of optical tweezers. Shortening the measurement time helps to reduce the risk of damage to biological samples due to light-induced heating. Measurements of biomechanical properties inside living cells require minimally invasive methods. Optical tweezers are particularly attractive as a tool. It uses the momentum of light to trap and manipulate micro- or nanoscale particles. A team…

New artificial intelligence software can compute protein structures in 10 minutes. Scientists have waited months for access to highly accurate protein structure prediction since DeepMind presented remarkable progress in this area at the 2020 Critical Assessment of Structure Prediction, or CASP14, conference. The wait is now over. Researchers at the Institute for Protein Design at the University of Washington School of Medicine in Seattle have largely recreated the performance achieved by DeepMind on this important task. These results will be…

Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles. Cancer cell death is triggered within three days when X-rays are shone onto tumor tissue containing iodine-carrying nanoparticles. The iodine releases electrons that break the tumor’s DNA, leading to cell death. The findings, by scientists at Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan and the US, were published in the journal Scientific Reports. “Exposing a metal to light leads to the release…

According to the World Health Organization, a third wave of COVID infections is now all but inevitable in Europe. A COVID tracker developed by IIASA researcher Asjad Naqvi, aims to identify, collect, and collate various official regional datasets for European countries, while also combining and homogenizing the data to help researchers and policymakers explore how the virus spreads. While many comparisons have been made between the COVID-19 pandemic and similar events in history, one thing sets this pandemic apart from…

Hollow nano-objects made of DNA could trap viruses and render them harmless. To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method. The strategy has already been tested against hepatitis and adeno-associated viruses in cell cultures. It may also prove successful against corona viruses. There are…

Scientists at Tokyo Institute of Technology have developed a computational method based on large-scale molecular dynamics simulations to predict the cell-membrane permeability of cyclic peptides using a supercomputer. Their protocol has exhibited promising accuracy and may become a useful tool for the design and discovery of cyclic peptide drugs, which could help us reach new therapeutic targets inside cells beyond the capabilities of conventional small-molecule drugs or antibody-based drugs. Cyclic peptide drugs have attracted the attention of major pharmaceutical companies…

Leanne Gilbertson’s group studies the mechanisms behind bacterial resistance to silver nanoparticles to determine if their ubiquitous use is a solution to the antimicrobial resistance challenge or if it is perhaps fueling the fire. Antimicrobials are used to kill or slow the growth of bacteria, viruses and other microorganisms. They can be in the form of antibiotics, used to treat bodily infections, or as an additive or coating on commercial products used to keep germs at bay. These life-saving tools…

USC Stem Cell scientists point to developmental and evolutionary similarities between sensory cells in the inner ear and the skin. The sensory cells in the inner ear and the touch receptors in the skin actually have a lot in common, according to a new study from the USC Stem Cell laboratory of Neil Segil published in the Proceedings of the National Academy of the Sciences (PNAS). “There are striking similarities in the development of two types of specialized sensory cells:…

Boosting the body’s own disease-fighting immune pathway could provide answers in the desperate search for new treatments for tuberculosis. Tuberculosis still represents an enormous global disease burden and is one of the top 10 causes of death worldwide. Led by WEHI’s Dr Michael Stutz and Professor Marc Pellegrini and published in Immunity, the study uncovered how cells infected with tuberculosis bacteria can die, and that using new medicines to enhance particular forms of cell death decreased the severity of the…

This pandemic year has seen us confined to our homes and restricted from travelling the world. Not so for some microscopic bacteria in the ocean: Throughout the globe, they partner up with clams from the family Lucinidae, which live unseen in the sand beneath the shimmering blue waters of coastal habitats. This partnership is the clams’ passport to their extensive global reach. The bacteria can also travel a long way. According to research by scientists from the Max Planck Institute…

– complex interactions of cells and tissue. In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs such as kidneys, lungs and mammary glands – but also in the development of tumors. Now a research team at the Technical University of Munich (TUM) has investigated the process in detail using organoids, three-dimensional model systems of such organs which are produced in the laboratory. Organoids are three-dimensional systems modeling various human organs. Grown…

When fluorescent dye molecules nestle perfectly together, something completely new is created: an excited state distributed over many molecules. Such collective excitations can be used in a variety of ways – for organic solar panels, in sensors, for ultrafast data transmission or in microscopy, for example. Empa researchers, together with colleagues from ETH Zurich, EPFL, the Paul Scherrer Institute (PSI) and IBM Research Zurich, have succeeded in making such chemical light amplifiers ten times more efficient than before. “What we…