A broad group of discoveries about the biological powers of “small-RNA” molecules, some of which were made by researchers at Oregon State University, will be hailed on Friday as the scientific “Breakthrough of the Year” by the journal Science. Science is published by the American Association for the Advancement of Science, the world’s largest general scientific society, and each year the prestigious journal identifies what it believes were the top 10 research advances of the year.
For 2
In a significant scientific advance, researchers at the Department of Energy’s Pacific Northwest National Laboratory have identified or confirmed 490 proteins in human blood serum — nearly doubling the number of known serum proteins, according to a paper accepted for publication in the December issue of Molecular and Cellular Proteomics.
“We have performed the most extensive identification of proteins in serum to date,” said Joel Pounds, corresponding author and a PNNL staff scientist. “We s
Two scientists at The Scripps Research Institute (TSRI), Research Associate John S. Reader, D.Phil, and Professor Gerald F. Joyce, M.D., Ph.D., both of the institute’s Department of Molecular Biology, have succeeded in creating an enzyme based on a “binary” genetic code–one containing only two different subunits.
This research, described in the latest issue of the journal Nature, demonstrates that Darwinian evolution can occur in a genetic system with only two bases, and it also suppo
A group of scientists at The Scripps Research Institute (TSRI) and San Diego Supercomputer Center at the University of California at San Diego (UCSD) have used a powerful laser in combination with innovative quantum mechanical computations to measure the flexibility of mouse antibodies.
The new technique, described in an upcoming issue of the journal Proceedings of the National Academy of Sciences, is significant because protein flexibility is believed to play an important role in antibody-a
How far up into the sky does the biosphere extend? Do microorganisms exist at heights of 40 km and in what quantity? To answer these questions several research institutes in India collaborated on a path-breaking project to send balloon-borne sterile “cryosamplers” into the stratosphere. The programme was led by cosmologist Professor Jayant Narlikar, Director of the Inter University Centre for Astronomy and Astrophysics in Pune, with scientists at the Indian Space Research Organisation and the Tata In
A rare type of the disease found mainly in Bedouins may provide insight into anemia
A combined effort between scientists at Schneider Children’s Medical Center of Israel, Tel Aviv University, and the Weizmann Institute of Science has led to the discovery of a gene responsible for a type of anemia primarily found in a number of Bedouin families, called congenital dyserythropoietic anemia-1 (CDA-1). The findings, published in the December issue of The American Journal for Human Gen
Dr. Mario Capecchi and colleagues at the University of Utah and the Department of Veterans Affairs Medical Center (Salt Lake City, UT) have discovered that a gene called xanthine oxidoreductase, or XOR for short, is required for lactation in female mice. This previously unidentified role for XOR in lactation reveals a possible genetic basis for the lactation difficulties experienced by nearly 5% of women.
XOR was originally identified as encoding an enzyme involved in purine catabolism (the
A key role in synchronizing daily rhythms to the day/night cycle has been traced to a light-sensitive protein in the eye, by knocking out the gene that codes for it. Mice lacking a gene for the photopigment melanopsin show a dramatic deficiency in their ability to regulate their circadian rhythms by light. The discovery, by National Institute of Mental Health (NIMH) grantees, helps unravel the heretofore elusive mechanisms by which day/night cycles regulate such rhythms in mammals. NIMH grantees Igna
Scientists at the University of Pennsylvania School of Veterinary Medicine have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types — B-cells and macrophages — long after what has been commonly regarded as the point of no return.
These latest fi
’Quantum dots’ may allow researchers to track proteins and cells in their natural environments
Imagine if molecular and cell biologists could watch proteins and cells at work in their natural habitat in the same way that wildlife biologists observe animals in the wild. They’d sit back and witness first hand their microscopic subjects’ daily routines, interactions and movements, and the places they prefer to be.
This fantasy is rapidly becoming a reality t
Scientists at UT Southwestern Medical Center at Dallas have identified a new and surprising mechanism by which a class of enzymes responsible for the breakdown of proteins operates.
The process of degrading proteins no longer needed by cells is essential in the normal growth, development and regulation of cells, and the study’s findings have implications for understanding diseases like Parkinson’s and several forms of cancer.
“Many diseases involve the inappropriate accumu
Researchers have discovered the first genetic component of a biochemical pathway in the brain that governs the indelible imprinting of fear-related experiences in memory.
The gene identified by researchers at the Howard Hughes Medical Institute at Columbia University encodes a protein that inhibits the action of the fear-learning circuitry in the brain. Understanding how this protein quells fear may lead to the design of new drugs to treat depression, panic and generalized anxiety di
With 46 chromosomes and six feet of DNA to copy every time most human cells divide, it’s not surprising that gaps or breaks sometimes show up in the finished product – especially when the cell is under stress or dividing rapidly, as in cancer.
But what is surprising – according to Thomas Glover, Ph.D., a geneticist at the University of Michigan Medical School – is that the breaks don’t always occur at random. They happen at a few specific locations on chromosomes, when cells are u
As mammals, our internal (circadian) clock is regulated by the patterns of light and dark we experience. But how that information is transmitted from the eye to the biological clock in the brain has been a matter of scientific debate. Scientists had suspected that a molecule called melanopsin, which is found in the retina, plays an important role.
Now researchers at Stanford University and Deltagen Inc. have confirmed that melanopsin does indeed transmit light information from the eye to th
Genome of Ciona intestinalis yields new insights into the origins of complex biological systems
The streamlined genome of Ciona intestinalis, a common sea squirt closely related to vertebrates on the evolutionary tree, is providing new clues about the origins of key vertebrate systems and structures including the human hormone, nervous and immune systems.
In an article for the December 13, 2002 issue of the journal Science, an international consortium of researchers reports
Using clusters of gold atoms and a microscopic lever, University of Toronto chemists have created a tiny circuit critical to the future of electronic engineering.
“When things are this small, they are fantastically sensitive,” says Professor Al-Amin Dhirani. “Such a circuit could make possible a bio-sensor that is activated by the reaction of just one molecule.” This has the potential for detecting important biological molecules including DNA, he notes.
Dhirani found that when the
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