Scientists studying the earliest mammals have been stumped for centuries about the function of two pelvic bones found in the fossil record that most mammals don’t have today. A study published in this week’s issue of the journal Science suggests those bones were involved in locomotion and helped the animals become more mobile, a find that could help researchers pinpoint a key moment in the evolution of mammals.
Biologists at Ohio University and Buffalo State College studied modern
Research conducted at Ohio State University suggests that cell biologists may be exposing the cell cultures they study to too much oxygen.
This finding could have broad implications for cellular biology research, which receives billions of dollars of funding nationally, said Ohio State scientist Chandan Sen. He is the lead author of a study which suggests that cells act differently depending on how much oxygen they are exposed to, especially when it is too much.
The air we br
Genetically engineered adult stem cell cultures will be accompanying Israel’s first astronaut, Col. Ilan Ramon, on his mission aboard the U.S. space shuttle Columbia, as part of research being carried out at the Hebrew University of Jerusalem.
The research focuses on building new, specialized cells through the use of adult stem cells, using techniques of genetic engineering. The technology is based on isolating adult stems cells taken from bone marrow and converting them into bone, cartilage
The cosmetic, textile, and food industries and even the construction industry use starch, the main energy reserve of plants, as a biodegradable and renewable substance for a variety of applications. To get to know the metabolism of this carbohydrate better and thus facilitate its industrial use and application, Milagros Rodríguez López proposed, in her PhD thesis, the identifying and isolating of the enzyme (or enzymes) responsible for the degradation activity of the precursor molecule for starch: A
Important goal achieved in potential animal-to-human organ transplantation
In a session today at the annual meeting of the International Embryo Transfer Society (IETS), Randall Prather, Ph.D., Distinguished Professor of Reproductive Biotechnology at the University of Missouri-Columbia, announced the successful cloning of the first miniature swine with both copies of a specific gene “knocked out” of its DNA. The ultimate goal of this research, which is being conducted in partnership wi
A research team led by Johns Hopkins scientists has discovered that a special, tiny group of cells at the back of the eye help tell the brain how much light there is, causing the pupil to get bigger or smaller. The findings, which appeared in the Jan. 10 issue of Science, largely complete the picture of how light levels are detected in the eye.
“This tiny group of cells, together with rods and cones, are the bulk of the eye’s mechanisms for detecting levels of light and passing that in
Scientists at The Scripps Research Institute (TSRI) report in an upcoming article in the Journal of the American Chemical Society their synthesis of a form of the bacterium Escherichia coli with a genetic code that uses 21 basic amino acid building blocks to synthesize proteins–instead of the 20 found in nature.
This is the first time that anyone has created a completely autonomous organism that uses 21 amino acids and has the metabolic machinery to build those amino acids.
“We
Expanding the genetic code: the world’s first truly unnatural organism
From time immemorial, every living thing has shared the same basic set of building blocks – 20 amino acids from which all proteins are made.
That is, until now: A group of scientists say they have, for the first time, created an organism that can produce a 21st amino acid and incorporate it into proteins completely on its own. The research should help probe some of the central questions of evolutionary theory.
ADE Biotec and the INASMET Foundation, both from the Basque Country, after three years of working together, have developed a new purification technique for purines. The technique is based on electroflotation and could be very beneficial for agriculture as it has a high level (80%+) of purification and very low costs (1 euro/m3). Most of the development project has been carried out at a pilot plant on a Toledo pig farm.
Nowadays purines (excrements plus sewage water from farms) constitute one
Researchers have identified a protein fragment that keeps at least one major tumor suppressor gene from preventing cancer like it should. The fragment belongs to a class of proteins known as apoptotic enhancers (ASPP), named for their ability to stimulate programmed cell death, or apoptosis, by the p53 gene.
But a study published in Nature Genetics finds that one member of this group, called iASPP, actually inhibits p53’s normal cell killing power. When iASPP levels were reduced in experime
With a high-tech fix for faulty cellular editing, scientists at Cold Spring Harbor Laboratory have moved a step closer to developing treatments for a host of diseases as diverse as breast cancer, muscular dystrophy, and cystic fibrosis.
Many human diseases have been linked to defects in a cellular editing process called pre-messenger RNA splicing. Adrian Krainer, a molecular biologist at Cold Spring Harbor Laboratory, has spent years investigating this complex editing process, which t
Researchers at the Stowers Institute for Medical Research are gaining new insight into the molecular players involved in the process of vertebral column formation in the embryo.
A research team headed by Dr. Olivier Pourquie, currently an Associate Scientist at the Stowers Institute, were pioneers in providing evidence for an oscillator called the segmentation clock, a timing mechanism responsible for the periodic production of the somites (the precursors of the vertebrae) in the embr
A Mayo Clinic investigation of Interleukin-6, a hormone inside cells often considered a “bad actor” of the immune system because of its association with inflammation injuries and malignant diseases, shows that it also plays a therapeutic role in mice: it protects brain cells.
Interleukin-6 — called IL-6 for short by researchers — may, in fact, be a “white knight” for mouse brain cells, or neurons, as brain cells also are called. These results, while early, may be promising for humans as w
Researchers are reporting progress in understanding whether a second light-sensing pathway in mammals indeed contributes to the detection of ambient light for controlling body functions.
In an article published in the January 10, 2003, issue of the journal Science, the researchers report that the molecule melanopsin is necessary in order for the pupil to constrict properly in response to light, a function termed the pupillary light reflex.
The latest findings by Howard Hughes Medi
Eating your own brain may not sound like a sensible approach to prolonging your life, but researchers at the University of Rochester have discovered that some single-celled organisms essentially do just that to keep themselves healthy. The findings are published in this month’s issue of Molecular Biology of the Cell.
David Goldfarb, professor of biology at the University of Rochester, studied the yeast Saccharomyces cerevisiae and found that contrary to what biologists have believed, th
Local fisheries part of bigger cycle affecting entire Pacific Ocean
In the late 1930’s, California’s sardines supported the biggest fishery in the western hemisphere, with more than half a million tons of fish caught each year. By the mid-1950s, the sardines had virtually disappeared. Although fishing pressure may have played a part in this process, new research published in the current issue of Science indicates that the sardines’ demise was part of a 50-year cycle tha
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