Scripps Research scientists used computer modeling to illustrate how antibodies use fatty molecules known as lipids to recognize the HIV virus. Lipids are the fatty molecules that make up cellular membranes, creating a protective barrier that regulates what enters and exits the cell. Until recently, scientists believed antibodies couldn’t safely target lipids without risking harm to healthy tissues, since the same lipids that appear in viruses are widely distributed throughout the body. Now, scientists at Scripps Research have used computer…
MRI technology reveals unhealthy lifestyles add decades Is your heart aging too fast? MRI technology reveals unhealthy lifestyles add decades Scientists at the University of East Anglia (UEA) have developed a revolutionary new way of uncovering the ‘true age’ of your heart using MRI. Research published today shows how an MRI scan can reveal your heart’s functional age – and how unhealthy lifestyles can dramatically accelerate this figure. It is hoped that the findings could transform how heart disease is diagnosed…
New research shows that a single mutation in the DNA sequence for a methylation enzyme causes a cascade of faulty gene expression, offering new avenues for blood cancer treatment Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key tumour-suppressing pathways, opening up new avenues for blood cancer treatment. The findings of this research confirm mutant DNA methyltransferase 3A (DNMT3A) as a potential target for effective blood cancer treatment. One of the…
Antibiotic resistance is a major public health issue. According to the WHO, 5 million people die every year worldwide as a result of antibiotic resistance[1]. This could become the leading cause of death by 2050. Although antibiotics have considerably reduced the mortality associated with infectious diseases, their sometimes excessive and abusive use has led to the development of bacterial resistance. Furthermore, as antibiotics generally target pathways essential for bacterial survival, they have a broad spectrum of action but lack specificity,…
Persistently high blood sugar and insulin resistance significantly increased the risk of worsening functional and structural heart damage during growth from adolescence to young adulthood, a new study shows. The study was conducted in collaboration between the Baylor College of Medicine in the US, the University of Bern in Switzerland, Murdoch Children’s Research Institute in Australia, the Universities of Bristol and Exeter in the UK, and the University of Eastern Finland. The results were published in the highly esteemed Diabetes…
Survival benefit prevails in low-, intermediate-, and high-risk subgroups Differentiated thyroid cancer patients who receive radioiodine (RAI) treatment after surgery have increased relative survival rates compared to those who do not receive the treatment. According to new research published in the April issue of The Journal of Nuclear Medicine, the clear trend for a higher long-term survival rate is observed in subgroups of patients with low- and intermediate-risk disease, while there is special benefit in high-risk disease. These findings confirm the benefit…
A novel combination of hydroxyl-enriched fullerenol and mTOR inhibitors reveals regulatory mechanisms of organelle communication networks in preclinical models, establishing a synergistic “nanomaterial + metabolic modulation” anticancer strategy. Breakthrough Cancer Strategy Hijacks Tumor Cells’ Survival Network Researchers have developed a nanoparticle-based therapy that disrupts cancer cells’ organelle communication system – the hidden network allowing tumors to resist conventional treatments. By combining multi-hydroxyl fullerene (MF) nanoparticles with mTOR inhibitors, this approach triggers the domino-like collapse of lysosomes (“cellular recycling centers”), mitochondria…
Dana-Farber Brigham Cancer Center-led phase 3 clinical trial shows that pembrolizumab before and after standard-of-care surgery significantly extends event-free survival, representing the first advance for these patients in over 20 years Immunotherapy before and after surgery improves outcomes in head and neck cancer Dana-Farber Brigham Cancer Center-led phase 3 clinical trial shows that pembrolizumab before and after standard-of-care surgery significantly extends event-free survival, representing the first advance for these patients in over 20 years Patients with locally advanced head…
Patients in a Phase 3 clinical trial who received sotorasib and panitumumab lived longer, suggesting the combination therapy could become the new standard of care. A novel combination therapy offers better outcomes for patients with KRAS G12C metastatic colorectal cancer that have stopped responding to chemotherapy, according to a Phase 3 clinical trial by researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., with its National Medical Center named…
At-home testing and patient choice credited for reducing racial disparities A 20-year initiative that offered flexible options for colorectal cancer screening at a major integrated health system doubled colorectal cancer screening rates, cut cancer incidence by a third, halved deaths, and brought racial differences in outcomes to nearly zero, according to a study to be presented at Digestive Disease Week® (DDW) 2025. “By offering an effective screening approach equally to everyone, we were able to eliminate much of the disparity,”…
One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ’s dense tissue to define the margins between malignant and normal tissue. A new study uses DNA origami structures to selectively deliver fluorescent imaging agents to pancreatic cancer cells without affecting normal cells. The study, led by University of Illinois Urbana-Champaign mechanical science and engineering professor Bumsoo Han and professor Jong Hyun Choi at Purdue University, found that specially engineered DNA origami structures carrying imaging dye…
Researchers from The University of Osaka discover that specific white blood cells and the amount of an inflammation protein in the blood can predict relapse of an autoimmune blood vessel disease Neutrophils, one of the immune system warriors that were thought to be all the same, turn out to be diverse. Unfortunately, these cells are also active in autoimmune diseases. New research from Japan has found that a certain subpopulation of these white blood cells can predict disease relapse at…
Multicenter study suggests stroke prevention guidelines may underestimate risk in patients with symptomatic mild carotid stenosis Ischemic stroke remains one of the leading causes of death and long-term disability worldwide, with narrowing of the carotid artery due to atherosclerosis contributing to up to 30% of all cases. For decades, medical practitioners have primarily relied on the degree of carotid narrowing (stenosis) to assess the risk of stroke and determine the best treatment options. However, mounting evidence suggests that this approach…
Amsterdam UMC-developed algorithm, based on the data of more than half a million patients, may soon offer GPs the chance to accelerate a diagnosis GPs may soon be able to identify patients with an increased risk of lung cancer up to 4 months earlier than is currently the case. The GP should be able to simply identify patients during a consultation with an algorithm created by researchers at Amsterdam UMC based on the data of more than half a million…
Researchers at Baylor College of Medicine, Texas Children’s Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps medulloblastoma, the most prevalent malignant brain tumor in children, spread and grow on the leptomeninges, the membranes surrounding the brain and spinal cord. They discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts that mediates recruitment and reprogramming of the latter to support tumor growth. The findings suggest that…
Researchers at Tulane University have identified a potential new way to treat idiopathic pulmonary fibrosis (IPF), a deadly and currently incurable lung disease that affects more than 3 million people worldwide. IPF is rapidly progressive and causes scarring in the lungs, making it difficult to breathe. Approximately 50% of patients die within three years of diagnosis, and current treatments can only slow the disease — not stop or reverse it. In a study published in the Journal of Clinical Investigation, Tulane scientists…
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