Wearables such as smart watches or sensor rings are already a routine part of everyday life and are also popular Christmas gifts. They track our pulse rate, count our steps or analyze our sleep patterns. How can they already influence our behavior today and what future developments are possible? In this interview, Can Dincer, who holds a Professorship of Sensors and Wearables for Healthcare at the Technical University of Munich (TUM) offers insights into his research. What do we mean…
Pancreatic cancer (pancreatic carcinoma) remains one of the most challenging forms of cancer to treat, spurring global efforts to explore new therapeutic avenues. One such groundbreaking initiative is the “mikroPank” research network, a collaboration between the University Medical Center Halle and the Institute of Pharmacy at Martin Luther University Halle-Wittenberg (MLU). This innovative project is setting new standards in the development of realistic tumor models to enhance the effectiveness of treatment strategies. The ambitious scope of “mikroPank” is supported by…
…shows promise in treating serious lung disease. EMBL scientists discover that an FDA-approved, over-the-counter cough syrup ingredient has potential to treat fibrotic lung disease. A common over-the-counter ingredient in many cough syrups may have a greater purpose for people suffering from lung fibrosis that is related to any number of serious health conditions. Scientists from EMBL Heidelberg were part of a collaborative effort to discover an effective treatment for lung fibrosis and found that the best candidate may be one…
Brain waves that allow memory consolidation are synchronized by breathing. The first time a breathing rhythm in the human hippocampus found during sleep Breathing is the metronome that coordinates sleep oscillations Findings are important for people with disordered breathing during sleep Breathing is a fundamental rhythm of memory consolidation Just as a conductor coordinates different instruments in an orchestra to produce a symphony, breathing coordinates hippocampal brain waves to strengthen memory while we sleep, reports a new Northwestern Medicine study….
Scientists from the National Reference Center for Vibrios and Cholera at the Institut Pasteur, in collaboration with the Centre hospitalier de Mayotte, have revealed the spread of a highly drug-resistant cholera strain. The study was published on December 12, 2024 in the New England Journal of Medicine. Cholera is an infectious diarrheal disease caused by certain bacteria of the species Vibrio cholerae. In its most severe forms, cholera is one of the most rapidly fatal infectious diseases: in the absence…
For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient’s response to CAR T cell therapy in real time. The organoid’s response to therapy mirrored the response of the actual tumor in the patient’s brain. That is, if the tumor-derived organoid shrunk after treatment, so did the patient’s actual tumor, according to new research from the Perelman School of Medicine at the University of Pennsylvania, published today in Cell…
MHH gastroenterologist Dr Bernd Heinrich is investigating how bacteria and immune cells exchange information in the tumour environment. The Else Kröner Fresenius Foundation has honoured him with a Memorial Fellowship worth 250,000 euros for his work. Bile duct cancer is a rare but serious disease that is usually fatal. Known technically as cholangiocarcinoma (CCA), it can affect the bile ducts inside and outside the liver. The frequency of cases is increasing worldwide and the chances of recovery are considered poor….
MHH physician Dr Stephan Traidl is investigating the effects of systemic therapies for atopic dermatitis. The Else Kröner Fresenius Foundation honours him with the Memorial Scholarship worth 250,000 euros. Unbearable itching and dry, flaky skin are among the typical signs of atopic dermatitis. It is one of the most common chronic inflammatory skin diseases. In Germany, up to 2.5 million people are affected every year, of which around 1.3 million are children and adolescents. The disease usually begins in infancy…
– a promising target for treating pain. Cellular studies reveal neuropilin-1 is required for signaling pain and may offer a new approach for developing or repurposing therapies to address chronic pain. Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a study published in the Journal of Clinical Investigation. The findings hold promise for…
Glyphosate exposure exacerbates Alzheimer’s disease-like pathology in mice even after a significant pause from exposure. The human brain is an incredibly adaptable organ, often able to heal itself even from significant trauma. Yet for the first time, new research shows even brief contact with a common herbicide can cause lasting damage to the brain, which may persist long after direct exposure ends. In a groundbreaking new study, Arizona State University researcher Ramon Velazquez and his colleagues at the Translational Genomics Research Institute…
An international research team with the significant involvement of Augsburg University Medicine has made significant progress in the risk assessment and treatment of extracranial malign rhabdoid tumours. Recently published in the renowned journal “Clinical Cancer Research,” the study, “Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumours: Toward an Integrated Model of High-Risk Tumours,” shows how clinical and molecular factors can influence disease progression and contribute to improvements in individual treatment. Malign rhabdoid tumours are rare and affect around…
A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research led by Weill Cornell Medicine investigators. The finding suggests that preclinical studies until now have overlooked a major influencer of mouse physiology. Scientists recently have come to appreciate the importance, for human health and disease, of microbes—often called “commensals”—that naturally dwell in the gut. Bacterial commensals, for example, are known to have a big influence on human immunity;…
A German Cancer Aid study offers people with Li-Fraumeni syndrome new preventive strategies: Researchers at Hannover Medical School (MHH) are investigating for the first time in a new efficacy study whether cancer-free survival can be extended in LFS sufferers with the daily intake of metformin. Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome (CPS) in which almost all sufferers are diagnosed with cancer at least once in their lives. Many are diagnosed as children or adolescents. In a new efficacy…
Researchers from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), who are also part of the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Alicante Institute for Health and Biomedical Research (ISABIAL), have developed a cellular fractionation protocol. This method allows for precise analysis of the proteins located in synaptic membranes and in membranes outside the synapses, known as extrasynaptic membranes, in…
… demonstrates efficacy and safety in preclinical models of HER2-positive solid tumors. The p95HER2 protein is found expressed in one third of HER2+ tumors, which represent 4% of all tumors. Led by VHIO investigators, CAR T cells targeting p95HER2 have been engineered to secrete the TECH2Me bispecific antibody. Both therapies specifically and independently recognize tumor cells. In addition, the TECH2Me bispecific antibody activates immune cells within the tumor microenvironment. This dual mechanism of action has demonstrated safety and achieved complete…
MHH researchers are developing an innovative drug to prevent the rejection of donor skin grafts. When people suffer severe burns, there is not only a risk of infection in the wound. The high loss of fluid can also result in life-threatening circulatory shock. Therefore, the destroyed skin must be replaced as quickly as possible. Ideally, the wounds are treated with the patient’s own skin from healthy parts of the body, so-called split-thickness skin grafts. However, the tissue is often insufficient…
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