Importance of RNA modifications for the development of resistance in fungi raises hope for more effective treatment of fungal infections. An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic. This has been discovered by a German-Austrian research team led by the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI). The study focused on the mold fungus 𝘈𝘴𝘱𝘦𝘳𝘨𝘪𝘭𝘭𝘶𝘴 𝘧𝘶𝘮𝘪𝘨𝘢𝘵𝘶𝘴, which can cause life-threatening infections, especially in…
An international team of researchers, including scientists from the HSE Centre for Language and Brain, has identified the causes of impairments in expressing grammatical tense in people with aphasia. They discovered that individuals with speech disorders struggle with both forming the concept of time and selecting the correct verb tense. However, which of these processes proves more challenging depends on the speaker’s language. The findings have been published in the journal Aphasiology. What is Aphasia? Aphasia is a severe speech disorder, often…
The Fiber Gap: A Growing Concern in American Diets Fiber is well known to be an important part of a healthy diet, yet less than 10% of Americans eat the minimum recommended amount. A new study from Stanford Medicine might finally convince us to fill our plates with beans, nuts, cruciferous veggies, avocados and other fiber-rich foods. The research, which will be published in Nature Metabolism on Jan. 9 identified the direct epigenetic effects of two common byproducts of fiber digestion and found that…
HIRI researchers uncover control mechanisms of polysaccharide utilization in Bacteroides thetaiotaomicron. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Julius-Maximilians-Universität (JMU) in Würzburg have identified a protein and a group of small ribonucleic acids (sRNAs) in Bacteroides thetaiotaomicron, which regulate sugar metabolism. These discoveries shed light on how this gut microbe adapts to varying nutritional conditions. The findings deepen our understanding of this bacterium’s role in the human gut and may pave the way for new…
Scientists show how a mutated gene harms red and white blood cells. LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have discovered how a mutated gene kicks off a dangerous chain of events during blood cell production. The study, published recently in the Proceedings of the National Academy of Sciences, reveals how a mutated gene called ASXL1 is involved in a disease called clonal hematopoiesis, a precursor to malignant diseases such as myeloid malignancies and chronic monomyelocytic leukemia. “We know that…
Jülich scientists use novel RNA technology to selectively switch off tumours in the brain. An Adaptable Platform Technology That Destroys Glioblastoma Cancer Cells Using novel RNA technology to selectively switch off tumors in the brain, excerpt from infographic. Copyright: Forschungszentrum Jülich / Bernd HoffmannUsing a special RNA molecule, a team led by Jülich scientists has specifically attacked and destroyed glioblastoma cancer cells. The so-called selectively expressed RNA (seRNA) causes the diseased cells to produce a protein that leads to their…
Can strength and endurance training be beneficial for patients with a certain form of heart failure? A research team from Greifswald investigated this question together with seven other research centers in Germany. In the largest study of its kind to date, the effect of one year of training on the health of patients was examined. The research team was able to prove that those affected benefited from better performance and resilience in everyday life. The results have now been published…
Children and young people with high levels of mental health needs are struggling to receive the help they need, or to have their difficulties recognised, according to a new study. STADIA Decodes Young People’s Emotional Struggles The STADIA trial, which is published in the Journal of Child Psychology and Psychiatry, was led by experts from the School of Medicine at the University of Nottingham, and was funded by the National Institute for Health and Care Research (NIHR). The large study, which spans different parts…
First large cohort study at the Heart and Diabetes Center NRW awarded – Hilke Jung presents research project at the FoRUM conference of the Ruhr University Bochum A working group led by Prof. Dr. Vera von Dossow, Director of the Institute for Anaesthesiology and Pain Therapy at the Heart and Diabetes Center NRW (HDZ NRW), Bad Oeynhausen, has now demonstrated for the first time in a large retrospective cohort study that longer and more frequent phases of intraoperatively low blood…
Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans – including those causing flu, COVID, whooping cough and tuberculosis. Real-Time Monitoring of Pathogens The new approach uses samples from infected humans to allow real-time monitoring of pathogens circulating in human populations, and enable vaccine-evading bugs to be quickly and automatically identified. This could inform the development of vaccines that are more effective in preventing disease. The approach…
A recent review is transforming the landscape of craniomaxillofacial bone regeneration with the introduction of personalized bioceramic grafts. This pioneering research explores the fabrication and clinical potential of synthetic grafts created through additive manufacturing (AM), addressing key limitations of traditional autogenous grafts. By focusing on 3D-printed bioceramics tailored to meet individual patient needs, the study marks a significant advancement in both precision medicine and patient-specific care, offering new hope for those requiring bone reconstruction. Challenges in Craniofacial Bone Reconstruction Craniofacial…
Cancer in children and adolescents is rare. Nevertheless, malignant diseases are still one of the most common causes of death in this age group. Survivors of childhood or adolescent cancer often suffer chronic health problems with increased morbidity and mortality rates. The most important known risk factor for childhood cancer is genetic predisposition to cancer. Certain disease-associated variants in a person’s genes increase the risk of developing cancer. ‘Understanding the causes of cancer in children and adolescents is essential in…
Many differences appeared to exist prior to any substance use, pointing to the role brain structure may play in substance use risk, NIH-supported study suggests. Studies reveal factors that expose adolescent vulnerabilities toward substance use A study of nearly 10,000 adolescents funded by the National Institutes of Health (NIH) has identified distinct differences in the brain structures of those who used substances before age 15 compared to those who did not. Many of these structural brain differences appeared to exist in…
Medical University of South Carolina Hollings Cancer Center researcher receives Department of Defense Early Career Scholar Award to improve immune therapies by targeting resistant kidney tumors. A Medical University of South Carolina Hollings Cancer Center researcher is exploring new ways to improve treatment options for kidney cancer patients. With funding from a Department of Defense (DOD) Academy of Kidney Cancer Investigators Early Career Scholar Award, Aguirre de Cubas, Ph.D., will investigate how the immune system can be boosted to detect and kill…
ASU- and Banner Alzheimer’s Institute-led study implicates link between a common virus and the disease, which travels from the gut to the brain and may be a target for antiviral treatments. Arizona State University and Banner Alzheimer’s Institute researchers, along with their collaborators, have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer’s disease in a subset of people. It is believed most humans are exposed to this virus — called…
The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a method that makes their identification much easier and faster: they light up genome sequences in the cell nucleus. In contrast to complex screenings using established methods, the NIS-Seq method can be used to investigate the genetic determinants of almost any biological process in human cells. The study has now…
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